دورية أكاديمية
أعرض في EDS

Assessment of the current status of real-world pharmacogenomic testing: informed consent, patient education, and related practices.

التفاصيل البيبلوغرافية
العنوان: Assessment of the current status of real-world pharmacogenomic testing: informed consent, patient education, and related practices.
المؤلفون: Pereira L; Marshfield Clinic Research Institute, Center for Precision Medicine Research, Marshfield Clinic Health Systems, Marshfield, WI, United States.; Division of Genetics and Metabolism, Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States., Haidar CE; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States., Haga SB; Program in Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC, United States., Cisler AG; Medical Genetics, Marshfield Clinic Health Systems, Marshfield, WI, United States., Hall A; Division of Genetics and Metabolism, Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.; Center for Human Genomics and Precision Medicine, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, WI, United States., Shukla SK; Marshfield Clinic Research Institute, Center for Precision Medicine Research, Marshfield Clinic Health Systems, Marshfield, WI, United States., Hebbring SJ; Marshfield Clinic Research Institute, Center for Precision Medicine Research, Marshfield Clinic Health Systems, Marshfield, WI, United States., Leary EJW; Marshfield Clinic Research Institute, Center for Precision Medicine Research, Marshfield Clinic Health Systems, Marshfield, WI, United States.
المصدر: Frontiers in pharmacology [Front Pharmacol] 2024 Feb 08; Vol. 15, pp. 1355412. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Media]
مستخلص: Introduction: The practice of informed consent (IC) for pharmacogenomic testing in clinical settings varies, and there is currently no consensus on which elements of IC to provide to patients. This study aims to assess current IC practices for pharmacogenomic testing. Methods: An online survey was developed and sent to health providers at institutions that offer clinical germline pharmacogenomic testing to assess current IC practices. Results: Forty-six completed surveys representing 43 clinical institutions offering pharmacogenomic testing were received. Thirty-two (74%) respondents obtain IC from patients with variability in elements incorporated. Results revealed that twenty-nine (67%) institutions discuss the benefits, description, and purpose of pharmacogenomic testing with patients. Less commonly discussed elements included methodology and accuracy of testing, and laboratory storage of samples. Discussion: IC practices varied widely among survey respondents. Most respondents desire the establishment of consensus IC recommendations from a trusted pharmacogenomics organization to help address these disparities.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Pereira, Haidar, Haga, Cisler, Hall, Shukla, Hebbring and Leary.)
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فهرسة مساهمة: Keywords: clinical implementation; genetic counseling; genetic testing; informed consent; pharmacogenetics; pharmacogenomics
تواريخ الأحداث: Date Created: 20240227 Latest Revision: 20240229
رمز التحديث: 20240229
مُعرف محوري في PubMed: PMC10895424
DOI: 10.3389/fphar.2024.1355412
PMID: 38410134
قاعدة البيانات: MEDLINE
الوصف
تدمد:1663-9812
DOI:10.3389/fphar.2024.1355412