دورية أكاديمية
Anti-inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN-EF006 of Vaccinium bracteatum.
| العنوان: | Anti-inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN-EF006 of Vaccinium bracteatum. |
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| المؤلفون: | Wang YY; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China., Pan YB; School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China., Wan ZY; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China., Li JJ; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China., Bao J; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China., Zhang JS; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China., Zhang H; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2024 Apr; Vol. 21 (4), pp. e202400002. Date of Electronic Publication: 2024 Mar 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مواضيع طبية MeSH: | Chaetomium*/chemistry , Vaccinium myrtillus* , Polyketides*/chemistry, Lipopolysaccharides/pharmacology ; Molecular Structure |
| مستخلص: | Seven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with three known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites have been elucidated by spectroscopic means including MS, NMR and electronic circular dichroism. A preliminary anti-inflammatory screening with the lipopolysaccharide (LPS) induced RAW264.7 cell model revealed moderate NO production inhibitory activity for compounds 1 and 4. In addition, the expression of three LPS-induced inflammatory factors IL-6, iNOS and COX-2 was also blocked by 1 and 4. (© 2024 Wiley‐VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | 2022KJ096 Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program; JQ201721 Natural Science Foundation of Shandong Province |
| فهرسة مساهمة: | Keywords: Anti-inflammation; Chaetomium sp.; Endophytic fungus; Polyketide; Vaccinium bracteatum |
| المشرفين على المادة: | 0 (Polyketides) 0 (Lipopolysaccharides) |
| تواريخ الأحداث: | Date Created: 20240227 Date Completed: 20240418 Latest Revision: 20240418 |
| رمز التحديث: | 20240418 |
| DOI: | 10.1002/cbdv.202400002 |
| PMID: | 38411310 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1612-1880 |
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| DOI: | 10.1002/cbdv.202400002 |