دورية أكاديمية
أعرض في EDS

Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women.

التفاصيل البيبلوغرافية
العنوان: Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women.
المؤلفون: Sah S; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia., Bifarin OO; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia., Moore SG; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia., Gaul DA; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia., Chung H; Department of Obstetrics and Gynecology, School of Medicine, Keimyung University, Daegu Republic of Korea., Kwon SY; Department of Pathology, School of Medicine, Keimyung University, Daegu, Republic of Korea., Cho H; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea., Cho CH; Department of Obstetrics and Gynecology, School of Medicine, Keimyung University, Daegu Republic of Korea., Kim JH; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim J; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana., Fernández FM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
المصدر: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 May 01; Vol. 33 (5), pp. 681-693.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print Cited Medium: Internet ISSN: 1538-7755 (Electronic) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : American Association for Cancer Research, c1991-
مواضيع طبية MeSH: Ovarian Neoplasms*/blood , Lipidomics*/methods, Humans ; Female ; Republic of Korea/epidemiology ; Middle Aged ; Biomarkers, Tumor/blood ; Adult ; Aged ; Lipid Metabolism ; Lipids/blood
مستخلص: Background: Distinguishing ovarian cancer from other gynecological malignancies is crucial for patient survival yet hindered by non-specific symptoms and limited understanding of ovarian cancer pathogenesis. Accumulating evidence suggests a link between ovarian cancer and deregulated lipid metabolism. Most studies have small sample sizes, especially for early-stage cases, and lack racial/ethnic diversity, necessitating more inclusive research for improved ovarian cancer diagnosis and prevention.
Methods: Here, we profiled the serum lipidome of 208 ovarian cancer, including 93 early-stage patients with ovarian cancer and 117 nonovarian cancer (other gynecological malignancies) patients of Korean descent. Serum samples were analyzed with a high-coverage liquid chromatography high-resolution mass spectrometry platform, and lipidome alterations were investigated via statistical and machine learning (ML) approaches.
Results: We found that lipidome alterations unique to ovarian cancer were present in Korean women as early as when the cancer is localized, and those changes increase in magnitude as the diseases progresses. Analysis of relative lipid abundances revealed specific patterns for various lipid classes, with most classes showing decreased abundance in ovarian cancer in comparison with other gynecological diseases. ML methods selected a panel of 17 lipids that discriminated ovarian cancer from nonovarian cancer cases with an AUC value of 0.85 for an independent test set.
Conclusions: This study provides a systemic analysis of lipidome alterations in human ovarian cancer, specifically in Korean women.
Impact: Here, we show the potential of circulating lipids in distinguishing ovarian cancer from nonovarian cancer conditions.
(©2024 The Authors; Published by the American Association for Cancer Research.)
References: Curr Biol. 2020 Oct 5;30(19):3775-3787.e7. (PMID: 32857977)
J Proteome Res. 2015 Jan 2;14(1):578-86. (PMID: 25365139)
Cancer. 2006 Feb 1;106(3):589-98. (PMID: 16369985)
Endocrinology. 2015 Jun;156(6):1975-81. (PMID: 25815421)
Ann Transl Med. 2017 Jul;5(13):276. (PMID: 28758102)
Cancer Res. 1996 Dec 1;56(23):5309-18. (PMID: 8968075)
BMC Cancer. 2020 Mar 12;20(1):200. (PMID: 32164586)
Cancer Epidemiol Biomarkers Prev. 2012 Nov;21(11):1902-12. (PMID: 22962405)
Front Oncol. 2023 Apr 14;13:1134763. (PMID: 37124505)
Front Oncol. 2016 Jan 07;5:300. (PMID: 26779443)
Adv Drug Deliv Rev. 2020;159:245-293. (PMID: 32711004)
Sci Rep. 2021 Sep 13;11(1):18156. (PMID: 34518593)
J Clin Oncol. 2002 Mar 1;20(5):1248-59. (PMID: 11870167)
Obstet Gynecol. 2002 Dec;100(6):1413-6. (PMID: 12468197)
Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):189-197. (PMID: 30262599)
Cell. 2011 Mar 4;144(5):646-74. (PMID: 21376230)
Mol Cancer. 2019 Aug 13;18(1):124. (PMID: 31409361)
Hum Pathol. 1997 Mar;28(3):321-31. (PMID: 9042797)
Cancers (Basel). 2020 Nov 19;12(11):. (PMID: 33228226)
Oncotarget. 2017 Oct 26;8(61):102912-102922. (PMID: 29262533)
Gynecol Oncol. 2010 Apr;117(1):18-22. (PMID: 20106512)
Gynecol Oncol. 2013 Feb;128(2):239-44. (PMID: 23063998)
Elife. 2017 Oct 31;6:. (PMID: 29087294)
Metabolites. 2020 Oct 19;10(10):. (PMID: 33086611)
Cancers (Basel). 2022 Apr 30;14(9):. (PMID: 35565391)
Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2504-2512. (PMID: 33051337)
CA Cancer J Clin. 2018 Jul;68(4):284-296. (PMID: 29809280)
Gynecol Oncol. 2000 Sep;78(3 Pt 2):S1-13. (PMID: 10985904)
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W606-12. (PMID: 17584797)
Talanta. 2016 Apr 1;150:88-96. (PMID: 26838385)
Sci Rep. 2015 Nov 17;5:16351. (PMID: 26573008)
Anal Chem. 2019 Mar 5;91(5):3590-3596. (PMID: 30758187)
BJOG. 2004 Jun;111(6):613-8. (PMID: 15198791)
Zhonghua Bing Li Xue Za Zhi. 2014 Oct;43(10):649-50. (PMID: 25567588)
Biochim Biophys Acta. 1998 Oct 2;1394(1):43-56. (PMID: 9767101)
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. (PMID: 29140435)
Proteomics. 2005 Nov;5(17):4589-96. (PMID: 16237736)
Biochem Int. 1989 Apr;18(4):759-65. (PMID: 2764976)
Acta Oncol. 2012 Apr;51(4):473-9. (PMID: 22283470)
Obstet Gynecol. 2011 Aug;118(2 Pt 1):280-288. (PMID: 21775843)
Obstet Gynecol. 2011 Oct;118(4):854-62. (PMID: 21934449)
Diagnostics (Basel). 2021 Mar 07;11(3):. (PMID: 33800113)
Oncotarget. 2017 May 9;8(19):32134-32146. (PMID: 28389631)
Clin Proteomics. 2021 Jan 7;18(1):4. (PMID: 33413078)
Cancers (Basel). 2019 Apr 28;11(5):. (PMID: 31035430)
Br J Cancer. 2018 Oct;119(7):847-854. (PMID: 30293997)
Am J Epidemiol. 2003 Oct 1;158(7):629-38. (PMID: 14507598)
Cancers (Basel). 2018 Nov 12;10(11):. (PMID: 30424539)
Cancers (Basel). 2021 Apr 07;13(8):. (PMID: 33917079)
Oncotarget. 2017 Jul 18;8(29):46834-46845. (PMID: 27564116)
Cancer. 2019 Jun 15;125(12):1963-1972. (PMID: 30835824)
Clin Chim Acta. 2018 Jun;481:108-114. (PMID: 29481776)
Eur J Gynaecol Oncol. 2008;29(2):158-61. (PMID: 18459552)
معلومات مُعتمدة: R01 CA218664 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Lipids)
تواريخ الأحداث: Date Created: 20240227 Date Completed: 20240501 Latest Revision: 20240503
رمز التحديث: 20240503
مُعرف محوري في PubMed: PMC11061607
DOI: 10.1158/1055-9965.EPI-23-1293
PMID: 38412029
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-7755
DOI:10.1158/1055-9965.EPI-23-1293