دورية أكاديمية
Exploring Factors That Influence Postexercise Glycemia in Youth With Type 1 Diabetes in the Real World: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study.
| العنوان: | Exploring Factors That Influence Postexercise Glycemia in Youth With Type 1 Diabetes in the Real World: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study. |
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| المؤلفون: | Sherr JL; Yale School of Medicine, New Haven, CT., Bergford S; Jaeb Center for Health Research, Tampa, FL., Gal RL; Jaeb Center for Health Research, Tampa, FL., Clements MA; Children's Mercy Hospital, Kansas City, MO., Patton SR; Nemours Children's Health, Jacksonville, FL., Calhoun P; Jaeb Center for Health Research, Tampa, FL., Beaulieu LC; Jaeb Center for Health Research, Tampa, FL., Riddell MC; Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada. |
| المصدر: | Diabetes care [Diabetes Care] 2024 May 01; Vol. 47 (5), pp. 849-857. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Alexandria Va : American Diabetes Association Original Publication: New York, American Diabetes Assn. |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 1*/drug therapy , Hypoglycemia*, Adolescent ; Child ; Female ; Humans ; Male ; Blood Glucose ; Blood Glucose Self-Monitoring ; Exercise/physiology ; Glucose ; Glycated Hemoglobin ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Insulin, Regular, Human |
| مستخلص: | Objective: To explore 24-h postexercise glycemia and hypoglycemia risk, data from the Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) study were analyzed to examine factors that may influence glycemia. Research Design and Methods: This was a real-world observational study with participant self-reported physical activity, food intake, and insulin dosing (multiple daily injection users). Heart rate, continuous glucose data, and available pump data were collected. Results: A total of 251 adolescents (42% females), with a mean ± SD age of 14 ± 2 years, and hemoglobin A1c (HbA1c) of 7.1 ± 1.3% (54 ± 14.2 mmol/mol), recorded 3,319 activities over ∼10 days. Trends for lower mean glucose after exercise were observed in those with shorter disease duration and lower HbA1c; no difference by insulin delivery modality was identified. Larger glucose drops during exercise were associated with lower postexercise mean glucose levels, immediately after activity (P < 0.001) and 12 to <16 h later (P = 0.02). Hypoglycemia occurred on 14% of nights following exercise versus 12% after sedentary days. On nights following exercise, more hypoglycemia occurred when average total activity was ≥60 min/day (17% vs. 8% of nights, P = 0.01) and on days with longer individual exercise sessions. Higher nocturnal hypoglycemia rates were also observed in those with longer disease duration, lower HbA1c, conventional pump use, and if time below range was ≥4% in the previous 24 h. Conclusions: In this large real-world pediatric exercise study, nocturnal hypoglycemia was higher on nights when average activity duration was higher. Characterizing both participant- and event-level factors that impact glucose in the postexercise recovery period may support development of new guidelines, decision support tools, and refine insulin delivery algorithms to better support exercise in youth with diabetes. (© 2024 by the American Diabetes Association.) |
| معلومات مُعتمدة: | The Leona M. and Harry B. Helmsley Charitable Trust |
| المشرفين على المادة: | 0 (Blood Glucose) IY9XDZ35W2 (Glucose) 0 (Glycated Hemoglobin) 0 (Hypoglycemic Agents) 0 (Insulin) 0 (Insulin, Regular, Human) |
| تواريخ الأحداث: | Date Created: 20240227 Date Completed: 20240422 Latest Revision: 20240620 |
| رمز التحديث: | 20240621 |
| DOI: | 10.2337/dc23-2212 |
| PMID: | 38412033 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1935-5548 |
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| DOI: | 10.2337/dc23-2212 |