دورية أكاديمية
أعرض في EDS

First in human measurements of abscess cavity optical properties and methylene blue uptake prior to photodynamic therapy by in vivo diffuse reflectance spectroscopy.

التفاصيل البيبلوغرافية
العنوان: First in human measurements of abscess cavity optical properties and methylene blue uptake prior to photodynamic therapy by in vivo diffuse reflectance spectroscopy.
المؤلفون: Hannan MN; University of Rochester, Department of Physics and Astronomy, Rochester, New York, United States., Sharma AK; University of Rochester Medical Center, Department of Imaging Sciences, Rochester, New York, United States., Baran TM; University of Rochester Medical Center, Department of Imaging Sciences, Rochester, New York, United States.; University of Rochester, Department of Biomedical Engineering, Rochester, New York, United States.; University of Rochester, The Institute of Optics, Rochester, New York, United States.
المصدر: Journal of biomedical optics [J Biomed Opt] 2024 Feb; Vol. 29 (2), pp. 027002. Date of Electronic Publication: 2024 Feb 27.
نوع المنشور: Clinical Trial, Phase I; Journal Article
اللغة: English
بيانات الدورية: Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society Country of Publication: United States NLM ID: 9605853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1560-2281 (Electronic) Linking ISSN: 10833668 NLM ISO Abbreviation: J Biomed Opt Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society, c1996-
مواضيع طبية MeSH: Methylene Blue*/pharmacology , Photochemotherapy*/methods, Humans ; Abscess ; Photosensitizing Agents/pharmacology ; Spectrum Analysis
مستخلص: Significance: Efficacious photodynamic therapy (PDT) of abscess cavities requires personalized treatment planning. This relies on knowledge of abscess wall optical properties, which we report for the first time in human subjects.
Aim: The objective was to extract optical properties and photosensitizer concentration from spatially resolved diffuse reflectance measurements of abscess cavities prior to methylene blue (MB) PDT, as part of a phase 1 clinical trial.
Approach: Diffuse reflectance spectra were collected at the abscess wall of 13 human subjects using a custom fiber-optic probe and optical spectroscopy system, before and after MB administration. A Monte Carlo lookup table was used to extract optical properties.
Results: Pre-MB abscess wall absorption coefficients at 665 nm were 0.15 ± 0.1    cm - 1 (0.03 to 0.36    cm - 1 ) and 10.74 ± 15.81    cm - 1 (0.08 to 49.3   cm - 1 ) post-MB. Reduced scattering coefficients at 665 nm were 8.45 ± 2.37    cm - 1 (4.8 to 13.2    cm - 1 ) and 5.6 ± 2.26    cm - 1 (1.6 to 9.9    cm - 1 ) for pre-MB and post-MB, respectively. Oxygen saturations were found to be 58.83 % ± 35.78 % (5.6% to 100%) pre-MB and 36.29 % ± 25.1 % (0.0001% to 76.4%) post-MB. Determined MB concentrations were 71.83 ± 108.22    μ M (0 to 311    μ M ).
Conclusions: We observed substantial inter-subject variation in both native wall optical properties and MB uptake. This underscores the importance of making these measurements for patient-specific treatment planning.
(© 2024 The Authors.)
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معلومات مُعتمدة: R01 EB029921 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: diffuse reflectance spectroscopy; hemodynamics; intra-abdominal abscess; methylene blue; optical properties; photodynamic therapy
المشرفين على المادة: T42P99266K (Methylene Blue)
0 (Photosensitizing Agents)
تواريخ الأحداث: Date Created: 20240228 Date Completed: 20240229 Latest Revision: 20240326
رمز التحديث: 20240326
مُعرف محوري في PubMed: PMC10898190
DOI: 10.1117/1.JBO.29.2.027002
PMID: 38414658
قاعدة البيانات: MEDLINE
الوصف
تدمد:1560-2281
DOI:10.1117/1.JBO.29.2.027002