دورية أكاديمية
أعرض في EDS

Coordinated metabolic responses to cyclophilin D deletion in the developing heart.

التفاصيل البيبلوغرافية
العنوان: Coordinated metabolic responses to cyclophilin D deletion in the developing heart.
المؤلفون: Beutner G; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA., Burris JR; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, NY 14642, USA., Collins MP; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA., Kulkarni CA; Department of Anesthesiology & Perioperative Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA., Nadtochiy SM; Department of Anesthesiology & Perioperative Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA., de Mesy Bentley KL; Department of Pathology & Laboratory Medicine and the Electron Microscope Resource, University of Rochester Medical Center, Rochester, NY 14642, USA., Cohen ED; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA., Brookes PS; Department of Anesthesiology & Perioperative Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA., Porter GA Jr; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Departments of Medicine (Aab Cardiovascular Research Institute) and Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
المصدر: IScience [iScience] 2024 Feb 09; Vol. 27 (3), pp. 109157. Date of Electronic Publication: 2024 Feb 09 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: In the embryonic heart, the activation of the mitochondrial electron transport chain (ETC) coincides with the closure of the cyclophilin D (CypD) regulated mitochondrial permeability transition pore (mPTP). However, it remains to be established whether the absence of CypD has a regulatory effect on mitochondria during cardiac development. Using a variety of assays to analyze cardiac tissue from wildtype and CypD knockout mice from embryonic day (E)9.5 to adult, we found that mitochondrial structure, function, and metabolism show distinct transitions. Deletion of CypD altered the timing of these transitions as the mPTP was closed at all ages, leading to coupled ETC activity in the early embryo, decreased citrate synthase activity, and an altered metabolome particularly after birth. Our results suggest that manipulating CypD activity may control myocyte proliferation and differentiation and could be a tool to increase ATP production and cardiac function in immature hearts.
Competing Interests: GAPJr is the Inventor and the University of Rochester is the Assignee of United States Patent No. “US 10,179,161 B2” dated 1/15/19 and entitled “Compositions and methods for enhancing cardiac function in the neonate” that is related to the work reported herein. All other authors declare no competing interests.
(© 2024 The Author(s).)
References: Brief Bioinform. 2010 Mar;11(2):253-64. (PMID: 19965979)
Cell. 2015 Jul 30;162(3):540-51. (PMID: 26232224)
Dev Cell. 2016 Nov 21;39(4):480-490. (PMID: 27840107)
Circ Res. 2013 Dec 6;113(12):1308-19. (PMID: 24062335)
Front Neurosci. 2023 Sep 12;17:1231584. (PMID: 37766787)
Science. 2015 Dec 4;350(6265):aad2459. (PMID: 26785495)
Adv Enzyme Regul. 1988;27:357-70. (PMID: 2854951)
Cell Stem Cell. 2022 May 5;29(5):840-855.e7. (PMID: 35395180)
Cell Rep. 2018 May 29;23(9):2617-2628. (PMID: 29847793)
Pediatr Cardiol. 2016 Dec;37(8):1507-1515. (PMID: 27562133)
FEBS J. 2020 Feb;287(3):417-438. (PMID: 31743572)
Dev Cell. 2023 Jun 19;58(12):1087-1105.e4. (PMID: 37148880)
Nat Genet. 2017 Jul;49(7):1152-1159. (PMID: 28530678)
J Am Heart Assoc. 2018 Oct 16;7(20):e010378. (PMID: 30371266)
Cell Metab. 2015 Aug 4;22(2):304-11. (PMID: 26212717)
Dev Biol. 1977 May;57(1):109-17. (PMID: 863101)
Front Physiol. 2018 Jul 19;9:959. (PMID: 30072919)
Acta Anat (Basel). 1980;108(2):144-52. (PMID: 7405533)
PLoS One. 2013 Dec 13;8(12):e83214. (PMID: 24349464)
Sci Rep. 2020 Oct 19;10(1):17599. (PMID: 33077793)
Nat Rev Mol Cell Biol. 2022 Apr;23(4):266-285. (PMID: 34880425)
J Physiol. 2012 Jul 15;590(14):3349-60. (PMID: 22586215)
J Mol Cell Cardiol. 2014 Sep;74:340-52. (PMID: 24984146)
Nat Protoc. 2012 May 31;7(6):1235-46. (PMID: 22653162)
Biomolecules. 2018 Dec 14;8(4):. (PMID: 30558250)
Cell Discov. 2022 Oct 11;8(1):106. (PMID: 36220812)
Pediatr Res. 2017 Jun;81(6):932-941. (PMID: 28141792)
Differentiation. 2017 Jul - Aug;96:1-14. (PMID: 28554048)
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10580-5. (PMID: 24979777)
Biochim Biophys Acta. 2015 Oct;1850(10):2041-7. (PMID: 25445707)
Methods Cell Biol. 2007;80:93-119. (PMID: 17445690)
Nature. 2022 Apr;604(7905):349-353. (PMID: 35388219)
J Vis Exp. 2017 Jun 1;(124):. (PMID: 28605384)
J Mol Cell Cardiol. 2015 Nov;88:64-72. (PMID: 26388263)
Nat Commun. 2020 Jan 3;11(1):102. (PMID: 31900386)
Cell Res. 2012 Jan;22(1):219-36. (PMID: 22143566)
J Mol Cell Cardiol. 2013 Mar;56:81-90. (PMID: 23262437)
Dev Cell. 2011 Sep 13;21(3):469-78. (PMID: 21920313)
Cell Death Differ. 2023 Aug;30(8):1869-1885. (PMID: 37460667)
Prog Pediatr Cardiol. 2011 May;31(2):75-81. (PMID: 21603067)
Geroscience. 2021 Aug;43(4):1683-1696. (PMID: 34132979)
Nat Commun. 2021 Jul 28;12(1):4583. (PMID: 34321484)
Mol Cell. 2015 Oct 1;60(1):47-62. (PMID: 26387735)
Elife. 2020 Aug 14;9:. (PMID: 32795389)
J Mol Cell Cardiol. 2018 Aug;121:155-162. (PMID: 29958828)
J Mol Cell Cardiol. 1994 Aug;26(8):1029-36. (PMID: 7799443)
Cell. 2014 Apr 24;157(3):565-79. (PMID: 24766806)
Cell Death Differ. 2019 May;26(5):826-842. (PMID: 30038385)
Methods Mol Biol. 2021;2276:103-112. (PMID: 34060035)
Cell. 2015 Jul 30;162(3):552-63. (PMID: 26232225)
Sci Rep. 2017 Nov 3;7(1):14488. (PMID: 29101324)
PLoS Biol. 2013 Sep;11(9):e1001666. (PMID: 24086110)
Mol Cell Biochem. 2000 Jul;210(1-2):47-52. (PMID: 10976757)
J Clin Invest. 2010 Oct;120(10):3680-7. (PMID: 20890047)
Am Heart J. 1989 Feb;117(2):489-92. (PMID: 2492740)
Circ Res. 2018 Jan 5;122(1):74-87. (PMID: 29021295)
PLoS One. 2014 Nov 26;9(11):e113330. (PMID: 25427064)
Nature. 2023 Jun;618(7964):365-373. (PMID: 37225978)
معلومات مُعتمدة: R01 HL144776 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: Biological sciences; Cell biology; Metabolomics; Physiology
سلسلة جزيئية: figshare 10.6084/m9.figshare.25050323
تواريخ الأحداث: Date Created: 20240228 Latest Revision: 20240803
رمز التحديث: 20240803
مُعرف محوري في PubMed: PMC10897919
DOI: 10.1016/j.isci.2024.109157
PMID: 38414851
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2024.109157