دورية أكاديمية
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The effect of insulin resistance in the association between obesity and hypertension incidence among Chinese middle-aged and older adults: data from China health and retirement longitudinal study (CHARLS).

التفاصيل البيبلوغرافية
العنوان: The effect of insulin resistance in the association between obesity and hypertension incidence among Chinese middle-aged and older adults: data from China health and retirement longitudinal study (CHARLS).
المؤلفون: Niu ZJ; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Cui Y; Department of Neurological Rehabilitation, North Hospital, Xi'an International Medical Center Hospital, Xi'an, China., Wei T; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Dou M; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Zheng BX; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Deng G; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Tian PX; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Wang Y; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
المصدر: Frontiers in public health [Front Public Health] 2024 Feb 13; Vol. 12, pp. 1320918. Date of Electronic Publication: 2024 Feb 13 (Print Publication: 2024).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Editorial Office
مواضيع طبية MeSH: Insulin Resistance* , Hypertension*/epidemiology, Middle Aged ; Humans ; Aged ; Incidence ; Longitudinal Studies ; Retirement ; Obesity/epidemiology ; China/epidemiology ; Glucose ; Triglycerides
مستخلص: Background and Aims: Obesity and insulin resistance are well-known important risk factors for hypertension. This study aimed to investigate the mediating effect of the triglyceride-glucose index (TyG) in the association between Chinese visceral obesity index (CVAI) and hypertension among Chinese middle-aged and older adults.
Methods: A total of 10,322 participants aged 45 years and older from CHARLS (2011-2018) were included. Baseline data were collected in 2011 and hypertension incidence data were gathered during follow-up in 2013, 2015 and 2018. Multivariate logistic regression models were constructed to investigate the association of CVAI and TyG with the incidence of hypertension. Additionally, mediation analyses were conducted to evaluate the mediating role of the TyG index in the relationship between CVAI and hypertension. Subgroup analysis was also performed.
Results: A total of 2,802 participants developed hypertension during the follow-up period. CVAI and TyG index were independently and significantly associated with hypertension incidence. Increasing quartiles of CVAI and TyG index were associated with high hypertension incidence in middle-aged and older adults. The TyG index was identified as a mediator in the relationship between CVAI and hypertension incidence, with a mediation effect (95% confidence interval) was 12.38% (6.75, 31.81%).
Conclusion: Our study found that CVAI and TyG were independently associated with hypertension incidence. TyG played a partial mediating effect in the positive association between CVAI and hypertension incidence.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Niu, Cui, Wei, Dou, Zheng, Deng, Tian and Wang.)
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فهرسة مساهمة: Keywords: China health and retirement longitudinal study; hypertension; insulin resistance; mediation effects; obesity
المشرفين على المادة: IY9XDZ35W2 (Glucose)
0 (Triglycerides)
تواريخ الأحداث: Date Created: 20240228 Date Completed: 20240229 Latest Revision: 20240506
رمز التحديث: 20240507
مُعرف محوري في PubMed: PMC10898648
DOI: 10.3389/fpubh.2024.1320918
PMID: 38414903
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-2565
DOI:10.3389/fpubh.2024.1320918