دورية أكاديمية
Antineoplastic Activity Evaluation of Brazilian Brown Propolis and Artepillin C in Colorectal Area of Wistar Rats.
| العنوان: | Antineoplastic Activity Evaluation of Brazilian Brown Propolis and Artepillin C in Colorectal Area of Wistar Rats. |
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| المؤلفون: | Pelegrini BB; Postgraduate Program in Health Sciences, State University of Maringa, Maringa, Brazil., Becker AA; Department of Medicine, Unicesumar, Maringa, Brazil., Ferreira CA; Department of Medicine, State University of Maringa, Maringa, Brazil., Machado GR; Department of Medicine, State University of Maringa, Maringa, Brazil., Gauer MA; Department of Medicine, State University of Maringa, Maringa, Brazil., Mazarin SR; Department of Medicine, State University of Maringa, Maringa, Brazil., Dembogurski DSO; Department of Natural Products and Mass Spectrometry (LaPNEM), Federal University of Mato Grosso do Sul, Campo Grande, Brazil., Kaneshima AMS; Department of Basic Health Sciences, State University of Maringa, Maringa, Brazil., Da Silva DB; Department of Natural Products and Mass Spectrometry (LaPNEM), Federal University of Mato Grosso do Sul, Campo Grande, Brazil., Becker TCA; Department of Basic Health Sciences, State University of Maringa, Maringa, Brazil. |
| المصدر: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2024 Feb 01; Vol. 25 (2), pp. 563-573. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention, |
| مواضيع طبية MeSH: | Colonic Neoplasms*/drug therapy , Propolis*/pharmacology , Propolis*/therapeutic use , Aberrant Crypt Foci*/drug therapy , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Phenylpropionates*, Rats ; Animals ; Male ; Rats, Wistar ; Proliferating Cell Nuclear Antigen/metabolism ; 1,2-Dimethylhydrazine/toxicity ; Brazil ; Carcinogens |
| مستخلص: | Objective: The study's aim was to evaluate Brazilian Brown Propolis (BBP) and Artepillin C (ARC) chemopreventive action in Wistar rats' colons. Methods: Fifty male Wistar rats were divided into ten experimental groups, including control groups, groups with and without 1,2-dimethylhydrazine (DMH) induction, and BBP, ARC, and ARC enriched fraction (EFR) treatments, for sixteen weeks. Aberrant crypt foci (ACF) were classified as hyperplastic or dysplastic, and proliferating cell nuclear antigen (PCNA) expression was quantified. Result: ACF amounts in experimental groups (induced or not) decreased in both colon portions, while the isolated Aberrant Crypt (AC) number increased. Experimental groups of animals showed higher hyperplasia and dysplasia amounts compared with control groups. The ACF dysplastic amount present in groups induced and treated, in both colon portions, had similar values to IDMH (DMH induction group without treatment). In addition, DMH was effective in ACF inducing and there was positive staining for PCNA in basal and upper dysplastic foci portions in all experimental groups, in the mitotic index (MI) evaluation. To conclude, considering all the experimental groups, the one treated with EFR (fraction enriched with ARC) had the lowest rates of cell proliferation. Conclusion: BBP and its derivatives prevented crypt cell clonal expansion. |
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| فهرسة مساهمة: | Keywords: 1; 2-DIMETHYLHYDRAZINE (DMH); BRAZILIAN BROWN PROPOLIS (BBP); Chemoprevention; aberrant crypt foci (ACF) |
| المشرفين على المادة: | 0 (Proliferating Cell Nuclear Antigen) 9009-62-5 (Propolis) 72944-19-5 (artepillin C) IX068S9745 (1,2-Dimethylhydrazine) 0 (Antineoplastic Agents) 0 (Carcinogens) 0 (Phenylpropionates) |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240229 Latest Revision: 20240510 |
| رمز التحديث: | 20240510 |
| مُعرف محوري في PubMed: | PMC11077124 |
| DOI: | 10.31557/APJCP.2024.25.2.563 |
| PMID: | 38415543 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2476-762X |
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| DOI: | 10.31557/APJCP.2024.25.2.563 |