دورية أكاديمية
Diagnosis of Lennox-Gastaut syndrome and strategies for early recognition.
| العنوان: | Diagnosis of Lennox-Gastaut syndrome and strategies for early recognition. |
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| المؤلفون: | Pujar S; Paediatric Neurosciences Department, Great Ormond Street Hospital for Children, London, UK.; Developmental Neurosciences Research & Teaching Department, University College London NIHR BRC Great Ormond Street Institute of Child Health, London, UK., Cross JH; Paediatric Neurosciences Department, Great Ormond Street Hospital for Children, London, UK.; Developmental Neurosciences Research & Teaching Department, University College London NIHR BRC Great Ormond Street Institute of Child Health, London, UK. |
| المصدر: | Expert review of neurotherapeutics [Expert Rev Neurother] 2024 Apr; Vol. 24 (4), pp. 383-389. Date of Electronic Publication: 2024 Feb 28. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101129944 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8360 (Electronic) Linking ISSN: 14737175 NLM ISO Abbreviation: Expert Rev Neurother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Future Drugs Ltd., 2001- |
| مواضيع طبية MeSH: | Lennox Gastaut Syndrome*/diagnosis , Epilepsy*/diagnosis , Epileptic Syndromes*/diagnosis , Status Epilepticus*/diagnosis , Epilepsy, Generalized*, Humans ; Electroencephalography ; Diagnosis, Differential |
| مستخلص: | Introduction: Lennox Gastaut syndrome (LGS) as an electroclinical diagnosis has been utilized as a clinical entity for more than 70 years. However, with the recognition of other distinct electroclinical epilepsy syndromes, no consistent single etiology, and the variability of criteria used in clinical trials, the clinical utility of such a diagnosis has been questioned. Recently, the International League Against Epilepsy for the first time defined diagnostic criteria for epilepsy syndromes, thereby allowing consistent language and inclusion criteria to be utilized. Areas Covered: Recent diagnostic criteria for syndrome diagnosis are explored as defined by the International League Against Epilepsy, with further literature reviewed to highlight relevant features, and differential diagnosis explored. Expert Opinion: Developmental and Epileptic Encephalopathy (DEE) is an overall term that may be descriptive of many different epilepsies, most of early onset, whether electroclinically or etiologically defined, of which LGS is one. Although we have moved forward in defining an increasing number of etiologically specific syndromes, this to date remains a minority of the DEEs. Although there is progress with precision medicine targeted at specific causes, the term LGS still remains useful as a diagnosis in defining treatment options, as well as overall prognosis. |
| فهرسة مساهمة: | Keywords: DEE; Lennox Gastaut syndrome; diagnostic challenge; early diagnosis; encephalopathy; syndrome-in-evolution; targeted therapy |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240312 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| DOI: | 10.1080/14737175.2024.2323568 |
| PMID: | 38415629 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-8360 |
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| DOI: | 10.1080/14737175.2024.2323568 |