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أعرض في EDS

Differential Effects of Type 2 Diabetes Treatment Regimens on Diabetes Distress and Depressive Symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

التفاصيل البيبلوغرافية
العنوان: Differential Effects of Type 2 Diabetes Treatment Regimens on Diabetes Distress and Depressive Symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
المؤلفون: Gonzalez JS; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY.; Division of Endocrinology and Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY.; New York-Regional Center for Diabetes Translation Research, Albert Einstein College of Medicine, Bronx, New York, NY., Bebu I; The Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Krause-Steinrauf H; The Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Hoogendoorn CJ; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY.; Division of Endocrinology and Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY., Crespo-Ramos G; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY.; Division of Endocrinology and Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY., Presley C; Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL., Naik AD; School of Public Health, University of Texas Health Science Center, Houston, TX., Kuo S; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI., Johnson ML; International Diabetes Center, Minneapolis, MN., Wexler D; Diabetes Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Crandall JP; Division of Endocrinology and Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY., Bantle AE; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN., Arends V; Advanced Research and Diagnostic Laboratory, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN., Cherrington AL; Department of Medicine (General Internal and Preventive Medicine), University of Alabama at Birmingham, Birmingham, AL.
مؤلفون مشاركون: GRADE Research Group
المصدر: Diabetes care [Diabetes Care] 2024 Apr 01; Vol. 47 (4), pp. 610-619.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
أسماء مطبوعة: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn.
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/drug therapy , Metformin*/therapeutic use , Sulfonylurea Compounds*, Adult ; Female ; Humans ; Middle Aged ; Male ; Liraglutide/therapeutic use ; Insulin Glargine/therapeutic use ; Depression/drug therapy ; Glucagon-Like Peptide 1 ; Blood Glucose ; Glycated Hemoglobin ; Hypoglycemic Agents/therapeutic use ; Sitagliptin Phosphate/therapeutic use ; Drug Therapy, Combination ; Treatment Outcome
مستخلص: Objective: We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative to other treatments.
Research Design and Methods: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) of adults with T2DM of <10 years' duration, HbA1c 6.8-8.5%, and taking metformin monotherapy randomly assigned participants to add insulin glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist liraglutide, or the dipeptidyl peptidase 4 inhibitor sitagliptin. The Emotional Distress Substudy enrolled 1,739 GRADE participants (mean [SD] age 58.0 [10.2] years, 32% female, 56% non-Hispanic White, 18% non-Hispanic Black, 17% Hispanic) and assessed diabetes distress and depressive symptoms every 6 months. Analyses examined differences at 1 year and over the 3-year follow-up.
Results: Across treatments, diabetes distress (-0.24, P < 0.0001) and depressive symptoms (-0.67, P < 0.0001) decreased over 1 year. Diabetes distress was lower at 1 year for the glargine group than for the other groups combined (-0.10, P = 0.002). Diabetes distress was also lower for liraglutide than for glimepiride or sitagliptin (-0.10, P = 0.008). Over the 3-year follow-up, there were no significant group differences in total diabetes distress; interpersonal diabetes distress remained lower for those assigned to liraglutide. No significant differences were observed for depressive symptoms.
Conclusions: Contrary to expectations, this randomized trial found no evidence for a deleterious effect of basal insulin on emotional distress. Glargine lowered diabetes distress modestly at 1 year rather than increasing it. Liraglutide also reduced diabetes distress at 1 year. Results can inform treatment decisions for adults with early T2DM.
(© 2024 by the American Diabetes Association.)
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معلومات مُعتمدة: UL1 TR000445 United States TR NCATS NIH HHS; United States HL NHLBI NIH HHS; UL1 TR002529 United States TR NCATS NIH HHS; UL1 TR002541 United States TR NCATS NIH HHS; UL1 TR000439 United States TR NCATS NIH HHS; P30 DK020541 United States DK NIDDK NIH HHS; UL1 TR002378 United States TR NCATS NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; UL1 TR002243 United States TR NCATS NIH HHS; UL1 TR002345 United States TR NCATS NIH HHS; UL1 TR002548 United States TR NCATS NIH HHS; U34 DK088043 United States DK NIDDK NIH HHS; R01 DK104845 United States DK NIDDK NIH HHS; UL1 TR002537 United States TR NCATS NIH HHS; P30 DK092926 United States DK NIDDK NIH HHS; UL1 TR002535 United States TR NCATS NIH HHS; P30 DK072476 United States DK NIDDK NIH HHS; P30 DK079626 United States DK NIDDK NIH HHS; UL1 TR001409 United States TR NCATS NIH HHS; U01 DK098246 United States DK NIDDK NIH HHS; UL1 TR001449 United States TR NCATS NIH HHS; UL1 TR002489 United States TR NCATS NIH HHS; U54 GM104940 United States GM NIGMS NIH HHS; UL1 TR001108 United States TR NCATS NIH HHS; P30 DK111022 United States DK NIDDK NIH HHS; R01DK104845 United States DK NIDDK NIH HHS; UL1 TR001425 United States TR NCATS NIH HHS; UM1 TR004528 United States TR NCATS NIH HHS; UL1 TR000170 United States TR NCATS NIH HHS; UL1 TR001102 United States TR NCATS NIH HHS; P30 DK017047 United States DK NIDDK NIH HHS; United States CC CDC HHS
فهرسة مساهمة: Investigator: JP Crandall; MD McKee; S Behringer-Massera; J Brown-Friday; E Xhori; K Ballentine-Cargill; S Duran; H Estrella; S Gonzalez de la Torre; J Lukin; LS Phillips; E Burgess; D Olson; M Rhee; P Wilson; TS Raines; J Boers; J Costello; M Maher-Albertelli; R Mungara; L Savoye; CA White; C Gullett; L Holloway; F Morehead; S Person; M Sibymon; S Tanukonda; C Adams; A Ross; A Balasubramanyam; R Gaba; E Gonzalez Hattery; A Ideozu; J Jimenez; G Montes; C Wright; P Hollander; E Roe; A Jackson; A Smiley; P Burt; L Estrada; K Chionh; F Ismail-Beigi; C Falck-Ytter; L Sayyed Kassem; A Sood; M Tiktin; T Kulow; C Newman; KA Stancil; B Cramer; J Iacoboni; MV Kononets; C Sanders; L Tucker; A Werner; A Maxwell; G McPhee; C Patel; L Colosimo; A Krol; R Goland; J Pring; L Alfano; P Kringas; C Hausheer; J Tejada; K Gumpel; A Kirpitch; H Schneier; JB Green; H AbouAssi; R Chatterjee; MN Feinglos; J English Jones; SA Khan; JB Kimpel; RP Zimmer; M Furst; BM Satterwhite; CR Thacker; K Evans Kreider; CN Mariash; KJ Mather; HM Ismail; A Lteif; M Mullen; T Hamilton; N Patel; G Riera; M Jackson; V Pirics; D Aguillar; D Howard; S Hurt; R Bergenstal; A Carlson; T Martens; M Johnson; R Hill; J Hyatt; C Jensen; M Madden; D Martin; H Willis; W Konerza; S Yang; K Kleeberger; R Passi; S Fortmann; M Herson; K Mularski; H Glauber; J Prihoda; B Ash; C Carlson; PA Ramey; E Schield; B Torgrimson-Ojerio; K Arnold; B Kauffman; E Panos; S Sahnow; K Bays; K Berame; J Cook; D Ghioni; J Gluth; K Schell; J Criscola; C Friason; S Jones; S Nazarov; J Barzilay; N Rassouli; R Puttnam; B Ojoawo; R Nelson; M Curtis; B Hollis; C Sanders-Jones; K Stokes; Z El-Haqq; A Kolli; T Tran; D Wexler; ME Larkin; J Meigs; B Chambers; A Dushkin; G Rocchio; M Yepes; B Steiner; H Dulin; M Cayford; K Chu; A DeManbey; M Hillard; K Martin; N Thangthaeng; L Gurry; R Kochis; E Raymond; V Ripley; C Stevens; J Park; V Aroda; A Ghazi; M Magee; A Ressing; A Loveland; M Hamm; M Hurtado; A Kuhn; J Leger; L Manandhar; F Mwicigi; O Sanchez; T Young; R Garg; V Lagari-Libhaber; HJ Florez; WM Valencia; J Marks; S Casula; L Oropesa-Gonzalez; L Hue; A Cuadot; R Nieto-Martinez; AK Riccio Veliz; M Gutt; YJ Kendal; B Veciana; A Ahmann; D Aby-Daniel; F Joarder; V Morimoto; C Sprague; D Yamashita; N Cady; N Rivera-Eschright; P Kirchhoff; B Morales Gomez; J Adducci; A Goncharova; SH Hox; H Petrovitch; M Matwichyna; V Jenkins; L Broadwater; RR Ishii; NO Bermudez; DS Hsia; WT Cefalu; FL Greenway; C Waguespack; E King; G Fry; A Dragg; B Gildersleeve; J Arceneaux; N Haynes; A Thomassie; M Pavlionis; B Bourgeois; C Hazlett; S Mudaliar; R Henry; S Boeder; J Pettus; E Diaz; D Garcia-Acosta; S Maggs; C DeLue; A Stallings; E Castro; S Hernandez; J Krakoff; JM Curtis; T Killean; M Khalid; E Joshevama; E Diaz; D Martin; K Tsingine; T Karshner; J Albu; FX Pi-Sunyer; S Frances; C Maggio; E Ellis; J Bastawrose; X Gong; MA Banerji; P August; M Lee; D Lorber; NM Brown; DH Josephson; LL Thomas; M Tsovian; A Cherian; MH Jacobson; MM Mishko; MS Kirkman; JB Buse; J Diner; J Dostou; S Machineni; L Young; K Bergamo; A Goley; J Kerr; JF Largay; S Guarda; J Cuffee; D Culmer; R Fraser; H Almeida; S Coffer; E Debnam; L Kiker; S Morton; K Josey; G Fuller; WT Garvey; AL Cherrington; D Dyer; MCR Lawson; O Griffith; A Agne; S McCullars; RM Cohen; J Craig; MC Rogge; K Burton; K Kersey; C Wilson; S Lipp; MB Vonder Meulen; C Adkins; T Onadeko; N Rasouli; C Baker; E Schroeder; M Razzaghi; C Lyon; R Penaloza; C Underkofler; R Lorch; S Douglass; S Steiner; WI Sivitz; E Cline; LK Knosp; J McConnell; T Lowe; WH Herman; R Pop-Busui; MH Tan; C Martin; A Waltje; A Katona; L Goodhall; R Eggleston; S Kuo; S Bojescu; S Bule; N Kessler; E LaSalle; K Whitley; ER Seaquist; A Bantle; T Harindhanavudhi; A Kumar; B Redmon; J Bantle; M Coe; M Mech; A Taddese; K Lesne; S Smith; C Desouza; L Kuechenmeister; V Shivaswamy; S Burbach; MG Rodriguez; K Seipel; A Alfred; AL Morales; J Eggert; G Lord; W Taylor; R Tillson; DS Schade; A Adolphe; M Burge; E Duran-Valdez; J Martinez; A Bancroft; S Kunkel; F Ali Jamaleddin Ahmad; D Hernandez McGinnis; B Pucchetti; E Scripsick; A Zamorano; RA DeFronzo; E Cersosimo; M Abdul-Ghani; C Triplitt; D Juarez; M Mullen; RI Garza; H Verastiqui; K Wright; C Puckett; P Raskin; C Rhee; S Abraham; LF Jordan; S Sao; L Morton; O Smith; L Osornio Walker; L Schnurr-Breen; R Ayala; RB Kreymer; D Sturgess; KM Utzschneider; SE Kahn; L Alarcon-Casas Wright; EJ Boyko; EC Tsai; DL Trence; S Trikudanathan; BN Fattaleh; BK Montgomery; KM Atkinson; A Kozedub; T Concepcion; C Moak; N Prikhodko; S Rhothisen; TA Elasy; S Martin; L Shackelford; R Goidel; N Hinkle; C Lovell; J Myers; J Lipps Hogan; JB McGill; M Salam; T Schweiger; S Kissel; C Recklein; MJ Clifton; W Tamborlane; A Camp; B Gulanski; SE Inzucchi; K Pham; M Alguard; P Gatcomb; K Lessard; M Perez; L Iannone; E Magenheimer; A Montosa; J Fradkin; HB Burch; AA Bremer; DM Nathan; JM Lachin; H Krause-Steinrauf; N Younes; I Bebu; N Butera; CJ Buys; A Fagan; Y Gao; A Ghosh; MR Gramzinski; SD Hall; E Kazemi; E Legowski; H Liu; C Suratt; M Tripputi; A Arey; M Backman; J Bethepu; C Lund; P Mangat Dhaliwal; P McGee; E Mesimer; L Ngo; M Steffes; J Seegmiller; A Saenger; V Arends; D Gabrielson; T Conner; S Warren; J Day; J Huminik; A Scrymgeour; EZ Soliman; Y Pokharel; ZM Zhang; C Campbell; J Hu; L Keasler; S Hensley; Y Li; R Mihalcea; DJ Min; V Perez-Rosas; L Prosser; L Resnicow; W Ye; H Shao; P Zhang; J Luchsinger; D Sanchez; S Assuras; E Groessl; F Sakha; H Chong; N Hillery; I Abdouch; G Bahtiyar; P Brantley; FE Broyles; G Canaris; P Copeland; JJ Craine; WL Fein; A Gliwa; L Hope; MS Lee; R Meiners; V Meiners; H O'Neal; JE Park; A Sacerdote; E Sledge; L Soni; J Steppel-Reznik; A Turchin; S Golden; J Gonzalez; A Naik; E Walker
المشرفين على المادة: 6KY687524K (glimepiride)
839I73S42A (Liraglutide)
2ZM8CX04RZ (Insulin Glargine)
89750-14-1 (Glucagon-Like Peptide 1)
0 (Blood Glucose)
0 (Glycated Hemoglobin)
0 (Hypoglycemic Agents)
9100L32L2N (Metformin)
TS63EW8X6F (Sitagliptin Phosphate)
0 (Sulfonylurea Compounds)
تواريخ الأحداث: Date Created: 20240228 Date Completed: 20240327 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC10973899
DOI: 10.2337/dc23-2459
PMID: 38416773
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-5548
DOI:10.2337/dc23-2459