دورية أكاديمية
Systemic Sirtuin 1 as a Potential Target to Mediate Interactions Between Body Fat and Testosterone Concentration in Master Athletes.
| العنوان: | Systemic Sirtuin 1 as a Potential Target to Mediate Interactions Between Body Fat and Testosterone Concentration in Master Athletes. |
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| المؤلفون: | Leite PLA; Graduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia, Taguatinga, Brazil., Maciel LA; Graduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia, Taguatinga, Brazil., da Silva Aguiar S; Physical Education Department, University Centre of the Federal District, Brasilia, Brazil., Sousa CV; Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA., Neves RVP; Graduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia, Taguatinga, Brazil., de Sousa Neto IV; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Campbell Simões L; Faculty of Biotechnology, University of Brasilia, Brasilia, Brazil., Rosa TDS; Graduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia, Taguatinga, Brazil., Simões HG; Graduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia, Taguatinga, Brazil. |
| المصدر: | Journal of aging and physical activity [J Aging Phys Act] 2024 Feb 28; Vol. 32 (3), pp. 438-445. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Human Kinetics Publishers, Inc Country of Publication: United States NLM ID: 9415639 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1543-267X (Electronic) Linking ISSN: 10638652 NLM ISO Abbreviation: J Aging Phys Act Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Champaign, IL : Human Kinetics Publishers, Inc., c1993- |
| مواضيع طبية MeSH: | Testosterone*/blood , Sirtuin 1*/blood , Sirtuin 1*/metabolism , Athletes* , Luteinizing Hormone*/blood, Humans ; Male ; Middle Aged ; Adipose Tissue/metabolism ; Adult ; Female |
| مستخلص: | Evidence indicates that master athletes have higher concentration of Sirtuin 1 (Sirt1), lower body fat (BF), and greater activity of the hypothalamic-pituitary-gonadal axis in comparison to untrained peers. However, no published data have demonstrated possible mediation effect of Sirt1 in the interaction of BF and testosterone in this population. Therefore, this study compared and verified possible associations between Sirt1, BF, fat mass index (FMI), testosterone, luteinizing hormone (LH), and testosterone/luteinizing hormone (T/LH) ratio in middle-aged master athletes (n = 54; 51.22 ± 7.76 years) and control middle-aged peers (n = 21; 47.76 ± 8.47 years). Venous blood was collected for testosterone, LH, and Sirt1. BF was assessed through skinfold protocol. Although LH concentration did not differ between groups, master athletes presented higher concentration of Sirt1, testosterone, and T/LH ratio, and lower BF and FMI in relation to age-matched nonathletes. Moreover, Sirt1 correlated positively with testosterone and T/LH ratio, negatively with BF, and was not significantly correlated with LH (mediation analysis revealed the effect of BF on testosterone is mediated by Sirt1 and vice versa; R2 = .1776; p = .032). In conclusion, master athletes have higher testosterone, T/LH ratio, and Sirt1, and lower BF and FMI in relation to untrained peers. Furthermore, Sirt1 was negatively associated with BF and positively associated with testosterone and T/LH ratio. These findings suggest that increased circulating Sirt1, possibly due to the master athlete's training regimens and lifestyle, exhibits a potential mediation effect on the interaction between endocrine function and body composition. |
| فهرسة مساهمة: | Keywords: adipose tissue; exercise; hormones |
| المشرفين على المادة: | 3XMK78S47O (Testosterone) EC 3.5.1.- (Sirtuin 1) 9002-67-9 (Luteinizing Hormone) EC 3.5.1.- (SIRT1 protein, human) |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240513 Latest Revision: 20240710 |
| رمز التحديث: | 20240710 |
| DOI: | 10.1123/japa.2023-0193 |
| PMID: | 38417433 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1543-267X |
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| DOI: | 10.1123/japa.2023-0193 |