دورية أكاديمية
How does the neurotoxin β-N-methylamino-L-alanine exist in biological matrices and cause toxicity?
| العنوان: | How does the neurotoxin β-N-methylamino-L-alanine exist in biological matrices and cause toxicity? |
|---|---|
| المؤلفون: | Li M; College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China., Qiu J; College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China; Key Laboratory of Marine Environment and Ecology, Ocean University of China, Ministry of Education, Qingdao 266100, China., Yan G; College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China., Zheng X; College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China., Li A; College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China; Key Laboratory of Marine Environment and Ecology, Ocean University of China, Ministry of Education, Qingdao 266100, China. Electronic address: lafouc@ouc.edu.cn. |
| المصدر: | The Science of the total environment [Sci Total Environ] 2024 Apr 20; Vol. 922, pp. 171255. Date of Electronic Publication: 2024 Feb 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Neurotoxins*/chemistry , Amino Acids, Diamino*/toxicity , Amino Acids, Diamino*/chemistry, Animals ; Humans ; Cyanobacteria Toxins ; Oxidative Stress |
| مستخلص: | The neurotoxin β-N-methylamino-L-alanine (BMAA) has been deemed as a risk factor for some neurodegenerative diseases such as amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC). This possible link has been proved in some primate models and cell cultures with the appearance that BMAA exposure can cause excitotoxicity, formation of protein aggregates, and/or oxidative stress. The neurotoxin BMAA extensively exists in the environment and can be transferred through the food web to human beings. In this review, the occurrence, toxicological mechanisms, and characteristics of BMAA were comprehensively summarized, and proteins and peptides were speculated as its possible binding substances in biological matrices. It is difficult to compare the published data from previous studies due to the inconsistent analytical methods and components of BMAA. The binding characteristics of BMAA should be focused on to improve our understanding of its health risk to human health in the future. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Binding characteristics; Neurotoxicity; Occurrence; Toxicological mechanism; β-N-methylamino-L-alanine (BMAA) |
| المشرفين على المادة: | 108SA6URTV (beta-N-methylamino-L-alanine) 0 (Neurotoxins) 0 (Amino Acids, Diamino) 0 (Cyanobacteria Toxins) |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240320 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| DOI: | 10.1016/j.scitotenv.2024.171255 |
| PMID: | 38417517 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
|---|---|
| DOI: | 10.1016/j.scitotenv.2024.171255 |