دورية أكاديمية
Improving gut health and growth in early life: a protocol for an individually randomised, two-arm, open-label, controlled trial of a synbiotic in infants in Kaffrine District, Senegal.
| العنوان: | Improving gut health and growth in early life: a protocol for an individually randomised, two-arm, open-label, controlled trial of a synbiotic in infants in Kaffrine District, Senegal. |
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| المؤلفون: | Momo Kadia B; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK benjamin.kadia@lstmed.ac.uk., Khouma M; Service de Parasitologie-Mycologie, Faculté de Médecine, Université Cheikh Anta Diop, Dakar, Senegal., Sow D; Service de Parasitologie-Mycologie, UFR Sciences de la Santé, Université Gaston Berger, Saint Louis, Senegal., Faye B; Service de Parasitologie-Mycologie, Faculté de Médecine, Université Cheikh Anta Diop, Dakar, Senegal., Ramsteijn AS; Rowett Institute, University of Aberdeen, Aberdeen, UK., Calvo-Urbano B; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK., Jobarteh ML; Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK., Ferguson E; Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK., Haggarty P; Rowett Institute, University of Aberdeen, Aberdeen, UK., Webster JP; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK., Walker AW; Rowett Institute, University of Aberdeen, Aberdeen, UK., Heffernan C; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK.; Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.; London International Development Centre, London, UK., Allen SJ; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. |
| المصدر: | BMJ paediatrics open [BMJ Paediatr Open] 2024 Feb 27; Vol. 8 (Suppl 1). Date of Electronic Publication: 2024 Feb 27. |
| نوع المنشور: | Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101715309 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-9772 (Electronic) Linking ISSN: 23999772 NLM ISO Abbreviation: BMJ Paediatr Open Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Publishing Group, [2017]- |
| مواضيع طبية MeSH: | Synbiotics*, Infant ; Infant, Newborn ; Humans ; Child, Preschool ; Senegal ; Intestine, Small/pathology ; Inflammation/pathology ; Hormones ; Randomized Controlled Trials as Topic |
| مستخلص: | Introduction: Infants exposed to enteropathogens through poor sanitation and hygiene can develop a subclinical disorder of the gut called environmental enteric dysfunction (EED), characterised by abnormal intestinal histology and permeability. EED can contribute to stunting through reduced digestion and absorption of nutrients, increased susceptibility to infections, increased systemic inflammation and inhibition of growth hormones. EED can be apparent by age 12 weeks, highlighting the need for early intervention. Modulating the early life gut microbiota using synbiotics may improve resistance against colonisation of the gut by enteropathogens, reduce EED and improve linear growth. Methods and Analysis: An individually randomised, two-arm, open-label, controlled trial will be conducted in Kaffrine District, Senegal. Infants will be recruited at birth and randomised to either receive a synbiotic containing two Bifidobacterium strains and one Lactobacillus strain, or no intervention, during the first 6 months of life. The impact of the intervention will be evaluated primarily by comparing length-for-age z-score at 12 months of age in infants in the intervention and control arms of the trial. Secondary outcome variables include biomarkers of intestinal inflammation, intestinal integrity and permeability, gut microbiota profiles, presence of enteropathogens, systemic inflammation, growth hormones, epigenetic status and episodes of illness during follow-up to age 24 months. Discussion: This trial will contribute to the evidence base on the use of a synbiotic to improve linear growth by preventing or ameliorating EED in a low-resource setting. Trial Registration Number: PACTR202102689928613. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.) |
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| فهرسة مساهمة: | Keywords: gastroenterology; growth; microbiology; molecular biology; parasitology |
| المشرفين على المادة: | 0 (Hormones) |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240304 |
| رمز التحديث: | 20240304 |
| مُعرف محوري في PubMed: | PMC10900337 |
| DOI: | 10.1136/bmjpo-2022-001629 |
| PMID: | 38417919 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2399-9772 |
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| DOI: | 10.1136/bmjpo-2022-001629 |