دورية أكاديمية
أعرض في EDS

Eggs for Improving Nutrition, cognitive development and reducing linear growth retardation among Infants and young Children (ENRICH): protocol of an egg supplementation trial among children aged 9-18 months in Hyderabad, India.

التفاصيل البيبلوغرافية
العنوان: Eggs for Improving Nutrition, cognitive development and reducing linear growth retardation among Infants and young Children (ENRICH): protocol of an egg supplementation trial among children aged 9-18 months in Hyderabad, India.
المؤلفون: Banjara SK; ICMR - National Institute of Nutrition, Hyderabad, India., Challa SR; ICMR - National Institute of Nutrition, Hyderabad, India drchallanin@gmail.com., Augustine LF; ICMR - National Institute of Nutrition, Hyderabad, India., Dasi T; ICMR - National Institute of Nutrition, Hyderabad, India., Madhari R; ICMR - National Institute of Nutrition, Hyderabad, India., Fernandez Rao S; ICMR - National Institute of Nutrition, Hyderabad, India., Palika R; ICMR - National Institute of Nutrition, Hyderabad, India., Pullakhandam R; ICMR - National Institute of Nutrition, Hyderabad, India., Kalashikam RR; ICMR - National Institute of Nutrition, Hyderabad, India., Kumar RN; ICMR - National Institute of Nutrition, Hyderabad, India., Palepu DP; ICMR - National Institute of Nutrition, Hyderabad, India., Chilumula M; ICMR - National Institute of Nutrition, Hyderabad, India., Selvaraj K; ICMR - National Institute of Nutrition, Hyderabad, India., Gopinath P; ICMR - National Institute of Nutrition, Hyderabad, India., Davies-Kershaw H; Department of Population Health, LSHTM, London, UK., Jobarteh ML; Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, UK., Haggarty P; University of Aberdeen, Aberdeen, UK., Heffernan C; Department of Pathobiology and Population Sciences, University of London, London, UK.; London International Development Centre (LIDC), London, UK., Ferguson E; London School of Hygiene and Tropical Medicine (LSHTM), London, UK., Kulkarni B; ICMR - National Institute of Nutrition, Hyderabad, India.
المصدر: BMJ paediatrics open [BMJ Paediatr Open] 2024 Feb 27; Vol. 8 (Suppl 1). Date of Electronic Publication: 2024 Feb 27.
نوع المنشور: Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101715309 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-9772 (Electronic) Linking ISSN: 23999772 NLM ISO Abbreviation: BMJ Paediatr Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Publishing Group, [2017]-
مواضيع طبية MeSH: Nutritional Status* , Mothers*, Infant ; Child ; Humans ; Female ; Pregnancy ; Child, Preschool ; Growth Disorders ; Dietary Supplements ; Cognition ; Randomized Controlled Trials as Topic ; Observational Studies as Topic
مستخلص: Introduction: Evidence on the impact of nutrient-rich animal source foods such as eggs for improving child growth and cognition is inconsistent. This study aims to examine the impact of an egg intervention in children, along with behaviour change communication (BCC) to the mother, on linear growth and cognition, and nutritional status in children aged 9-18 months.
Methods and Analysis: A 9-month open-labelled randomised controlled trial will be conducted in three urban slums in Hyderabad, India, as a substudy of an observational cohort study (n=350) following pregnant women and their children until 18 months of age in a population at risk of stunting. The children born to women enrolled during the third trimester of pregnancy will be block randomised in a 1:4 ratio into the intervention (n=70) and control (n=280) groups. Children in the intervention group will be supplemented with one egg per day starting from 9 months until 18 months of age. BCC designed to enhance adherence to the intervention will be used. The control group will be a part of the observational cohort and will not receive any intervention from the study team. The primary outcome will be length-for-age z-scores, and the secondary outcomes will include cognition, blood biomarkers of nutritional status including fatty acid profile and epigenetic signatures linked with linear growth and cognition. Multivariate intention-to-treat analyses will be conducted to assess the effect of the intervention.
Ethics and Dissemination: The study is approved by the Institutional ethics committees of ICMR-National Institute of Nutrition, Hyderabad, India and London School of Hygiene and Tropical Medicine, UK. The results will be published in peer-reviewed journals and disseminated to policy-makers. Findings will also be shared with study participants and community leaders.
Trial Registration Number: CTRI/2021/11/038208.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
References: Int J Environ Res Public Health. 2011 Jun;8(6):1817-46. (PMID: 21776204)
Allergy. 2014 May;69(5):590-601. (PMID: 24697491)
Int J Epidemiol. 2015 Dec;44(6):1862-76. (PMID: 26275453)
BMC Public Health. 2013;13 Suppl 3:S13. (PMID: 24564534)
Int J Mol Sci. 2018 Nov 01;19(11):. (PMID: 30388784)
Trials. 2020 Jan 31;21(1):127. (PMID: 32005294)
BMJ Open. 2020 Jun 7;10(6):e035258. (PMID: 32513882)
Adv Nutr. 2019 Mar 1;10(2):196-204. (PMID: 30801614)
Korean J Anesthesiol. 2013 May;64(5):402-6. (PMID: 23741561)
Pediatrics. 2017 Jul;140(1):. (PMID: 28588101)
Sci Rep. 2021 Jan 13;11(1):943. (PMID: 33441584)
Child Care Health Dev. 2021 May;47(3):336-348. (PMID: 33377201)
Am J Clin Nutr. 2019 Oct 1;110(4):1026-1033. (PMID: 31386106)
PLoS One. 2019 Feb 1;14(2):e0211799. (PMID: 30707743)
Am J Clin Nutr. 2021 Feb 2;113(2):420-427. (PMID: 33330913)
Matern Child Nutr. 2018 Oct;14 Suppl 3:e12678. (PMID: 30332538)
Eur J Clin Nutr. 2014 Jun;68(6):658-63. (PMID: 24642784)
West J Emerg Med. 2017 Oct;18(6):1075-1078. (PMID: 29085540)
Nutrients. 2017 Apr 29;9(5):. (PMID: 28468239)
Nutrients. 2020 Aug 11;12(8):. (PMID: 32796704)
Lancet Child Adolesc Health. 2021 May;5(5):367-384. (PMID: 33691083)
Dev Psychol. 2016 Sep;52(9):1409-21. (PMID: 27505702)
Matern Child Nutr. 2013 Jan;9(1):99-117. (PMID: 22625182)
PLoS One. 2013 May 30;8(5):e61486. (PMID: 23737940)
Food Nutr Bull. 2018 Sep;39(2_suppl):S69-S76. (PMID: 30238797)
Nutr Rev. 2014 Jun;72(6):355-68. (PMID: 24807641)
Am J Clin Nutr. 2000 Sep;72(3):702-7. (PMID: 10966887)
فهرسة مساهمة: Keywords: Child Psychiatry; Epidemiology; Growth; Health services research; Nutrition
تواريخ الأحداث: Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240304
رمز التحديث: 20240304
مُعرف محوري في PubMed: PMC10900354
DOI: 10.1136/bmjpo-2023-001892
PMID: 38417922
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-9772
DOI:10.1136/bmjpo-2023-001892