دورية أكاديمية
Assessment of the role of gut health in childhood stunting in a multisite, longitudinal study in India, Indonesia and Senegal: a UKRI GCRF Action Against Stunting Hub protocol.
| العنوان: | Assessment of the role of gut health in childhood stunting in a multisite, longitudinal study in India, Indonesia and Senegal: a UKRI GCRF Action Against Stunting Hub protocol. |
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| المؤلفون: | Momo Kadia B; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK benjamin.kadia@lstmed.ac.uk., Ramsteijn AS; Rowett Institute, University of Aberdeen, Aberdeen, UK., Dasi T; ICMR-National Institute of Nutrition, Hyderabad, India., Fahmida U; Southeast Asian Ministry of Education Organisation Regional Centre for Food and Nutrition (SEAMEO RECFON), East Jakarta, Indonesia., Kulkarni B; ICMR-National Institute of Nutrition, Hyderabad, India., Faye B; Service de Parasitologie-Mycologie, Faculté de Médecine, Université Cheikh Anta Diop (UCAD), Dakar, Sénégal., Htet MK; Southeast Asian Ministry of Education Organisation Regional Centre for Food and Nutrition (SEAMEO RECFON), East Jakarta, Indonesia., Sow D; Service de Parasitologie-Mycologie, UFR Sciences de la Santé, Université Gaston Berger, Saint Louis, Sénégal., Kalashikam RR; ICMR-National Institute of Nutrition, Hyderabad, India., Sharma R; ICMR-National Institute of Nutrition, Hyderabad, India., Sudibya ARP; Southeast Asian Ministry of Education Organisation Regional Centre for Food and Nutrition (SEAMEO RECFON), East Jakarta, Indonesia., Kusuma S; Southeast Asian Ministry of Education Organisation Regional Centre for Food and Nutrition (SEAMEO RECFON), East Jakarta, Indonesia., Angelin TC; Southeast Asian Ministry of Education Organisation Regional Centre for Food and Nutrition (SEAMEO RECFON), East Jakarta, Indonesia., Nurfadilah M; Southeast Asian Ministry of Education Organisation Regional Centre for Food and Nutrition (SEAMEO RECFON), East Jakarta, Indonesia., Jobarteh ML; Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK., Diop NS; Service de Parasitologie-Mycologie, Faculté de Médecine, Université Cheikh Anta Diop (UCAD), Dakar, Sénégal., Gabain I; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK., Calvo-Urbano B; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK., Ferguson E; Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK., Haggarty P; Rowett Institute, University of Aberdeen, Aberdeen, UK., Heffernan C; Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.; London International Development Centre, London, UK., Webster JP; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK., Walker AW; Rowett Institute, University of Aberdeen, Aberdeen, UK., Allen S; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. |
| المصدر: | BMJ paediatrics open [BMJ Paediatr Open] 2024 Feb 27; Vol. 8 (Suppl 1). Date of Electronic Publication: 2024 Feb 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101715309 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-9772 (Electronic) Linking ISSN: 23999772 NLM ISO Abbreviation: BMJ Paediatr Open Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Publishing Group, [2017]- |
| مواضيع طبية MeSH: | Mothers* , Growth Disorders*/epidemiology , Growth Disorders*/etiology, Infant ; Child ; Pregnancy ; Humans ; Infant, Newborn ; Female ; Child, Preschool ; Longitudinal Studies ; Indonesia/epidemiology ; Senegal/epidemiology ; Inflammation/complications ; Hormones ; Observational Studies as Topic |
| مستخلص: | Introduction: Childhood stunting has a complex aetiology, with poor gut health being an important contributor. This study will assess inter-relationships between maternal and infant gut health indices and infant linear growth. Inter-relationships between gut health indices, systemic inflammation and growth hormones in early childhood will also be assessed. Methods and Analysis: A longitudinal observational study of cohorts of 600 newborns and their mothers in India, Indonesia and Senegal will be conducted. Women will be recruited during pregnancy and their children followed up to age 24 months. Stool, urine and blood samples will be collected from the women and children for assessments of helminthic and protozoal parasites, bacterial pathogens, faecal microbiota taxa, biomarkers of environmental enteric dysfunction, systemic inflammation and growth hormones. Child anthropometric measurements will be collected at birth and at ages 3, 6, 9, 12, 18 and 24 months. The gut health indices will be integrated with cohort data from other Action Against Stunting Hub (AASH) workstreams for interdisciplinary analyses of childhood stunting and the development of a new typology of stunting. Discussion: This study will advance scientific understanding of the role of gut health in childhood stunting and will contribute to a broader knowledge of the complex aetiology of this condition as part of the interdisciplinary AASH research to reduce the global burden of childhood stunting. Ethics and Dissemination: This study has been approved by the relevant Ethics Committees in Senegal, India, and Indonesia and LSHTM. The results will be submitted for publication in peer-reviewed journals. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.) |
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| معلومات مُعتمدة: | MR/S01313X/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: gastroenterology; growth; microbiology; molecular biology; parasitology |
| المشرفين على المادة: | 0 (Hormones) |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| مُعرف محوري في PubMed: | PMC10900321 |
| DOI: | 10.1136/bmjpo-2022-001637 |
| PMID: | 38417928 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2399-9772 |
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| DOI: | 10.1136/bmjpo-2022-001637 |