دورية أكاديمية
Organize and mobilize for implementation effectiveness to improve overdose education and naloxone distribution from syringe services programs: a randomized controlled trial.
العنوان: | Organize and mobilize for implementation effectiveness to improve overdose education and naloxone distribution from syringe services programs: a randomized controlled trial. |
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المؤلفون: | Lambdin BH; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA. blambdin@rti.org.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. blambdin@rti.org.; Department of Global Health, University of Washington, Seattle, WA, USA. blambdin@rti.org., Bluthenthal RN; Keck Medicine, Department of Population and Public Health Sciences, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA., Garner BR; Department of Internal Medicine, College of Medicine, The Ohio State University, 370 W. 9Th Avenue, Columbus, OH, 43210, USA., Wenger LD; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Browne EN; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Morris T; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Ongais L; San Francisco AIDS Foundation, 1035 Market Street, 4Th Floor, San Francisco, CA, 94103, USA., Megerian CE; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Kral AH; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA. |
المصدر: | Implementation science : IS [Implement Sci] 2024 Feb 28; Vol. 19 (1), pp. 22. Date of Electronic Publication: 2024 Feb 28. |
نوع المنشور: | Randomized Controlled Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101258411 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-5908 (Electronic) Linking ISSN: 17485908 NLM ISO Abbreviation: Implement Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2006- |
مواضيع طبية MeSH: | Opiate Overdose*/drug therapy , Drug Overdose*/drug therapy , Drug Overdose*/prevention & control , Opioid-Related Disorders*/drug therapy, Humans ; United States ; Naloxone/therapeutic use ; Health Education ; United States Department of Veterans Affairs ; Narcotic Antagonists/therapeutic use |
مستخلص: | Background: The United States (US) continues to face decades-long increases in opioid overdose fatalities. As an opioid overdose reversal medication, naloxone can dramatically reduce opioid overdose mortality rates when distributed to people likely to experience or witness an opioid overdose and packaged with education on its use, known as overdose education and naloxone distribution (OEND). Syringe services programs (SSPs) are ideal venues for OEND with staff who are culturally competent in providing services for people who are at risk of experiencing or observing an opioid overdose. We carried out a randomized controlled trial of SSPs to understand the effectiveness of the organize and mobilize for implementation effectiveness (OMIE) approach at improving OEND implementation effectiveness within SSPs. Methods: Using simple randomization, 105 SSPs were enrolled into the trial and assigned to one of two study arms - (1) dissemination of OEND best practice recommendations (Control SSPs) or the OMIE approach along with dissemination of the OEND best practice recommendations (i.e., OMIE SSPs). OMIE SSPs could participate in 60-min OMIE sessions once a month for up to 12 months. At 12-month post-baseline, 102 of 105 SSPs (97%) responded to the follow-up survey. Results: The median number of sessions completed by OMIE SSPs was 10. Comparing OMIE SSPs to control SSPs, we observed significant increases in the number of participants receiving naloxone (incidence rate ratio: 2.15; 95% CI: 1.42, 3.25; p < 0.01) and the rate of naloxone doses distributed per SSP participant (adjusted incidence rate ratio: 1.97; 95% CI: 1.18, 3.30; p = 0.01). We observed no statistically significant difference in the number of adopted best practices between conditions (difference in means 0.2, 95% CI: - 0.7, 1.0; p = 0.68). We also observed a threshold effect where SSPs receiving a higher OMIE dose had greater effect sizes with regard to the number of people given naloxone and the number of naloxone doses distributed. Conclusions: In conclusion, the multifaceted OMIE approach was effective at increasing naloxone distribution from SSPs, despite substantial external shocks during the trial. These findings have major implications for addressing the overdose crisis, which has continued unabated for decades. Trial Registration: ClinicalTrials.gov, NCT03924505 . Registered 19 April 2019. (© 2024. The Author(s).) |
References: | Implement Sci. 2016 May 31;11(1):78. (PMID: 27245158) BMJ. 2010 Mar 23;340:c332. (PMID: 20332509) Med J Aust. 2005 Jan 3;182(1):24-7. (PMID: 15651944) Int J Drug Policy. 2018 May;55:61-69. (PMID: 29524734) Addiction. 2016 May;111(5):883-91. (PMID: 26642424) Implement Sci. 2017 Mar 9;12(1):34. (PMID: 28279207) Implement Sci. 2015 Oct 25;10:147. (PMID: 26498746) Health Educ Res. 2009 Apr;24(2):292-305. (PMID: 18469319) J Urban Health. 2003 Jun;80(2):288-90. (PMID: 12791804) Adm Policy Ment Health. 2011 Mar;38(2):65-76. (PMID: 20957426) Addict Sci Clin Pract. 2017 Nov 17;12(1):31. (PMID: 29149914) J Gen Intern Med. 2014 Dec;29 Suppl 4:904-12. (PMID: 25355087) Am J Public Health. 2009 May;99(5):788-91. (PMID: 19363214) Int J Drug Policy. 2018 Feb;52:52-55. (PMID: 29232604) Transl Behav Med. 2014 Jun;4(2):175-83. (PMID: 24904701) J Addict Med. 2014 May-Jun;8(3):153-63. (PMID: 24874759) Int J Drug Policy. 2019 Aug;70:22-32. (PMID: 31059965) J Emerg Med. 2005 Oct;29(3):265-71. (PMID: 16183444) Implement Sci. 2014 Sep 30;9:132. (PMID: 25267385) Emerg Med J. 2006 Mar;23(3):221-3. (PMID: 16498165) Addict Sci Clin Pract. 2017 Nov 17;12(1):32. (PMID: 29149909) Drug Alcohol Depend. 2018 Jul 1;188:370-376. (PMID: 29776688) BMJ. 2014 Mar 07;348:g1687. (PMID: 24609605) Emerg Nurse. 2007 May;15(2):30-5. (PMID: 17542332) Implement Sci. 2013 Nov 20;8:136. (PMID: 24252648) Prehosp Emerg Care. 2006 Oct-Dec;10(4):468-71. (PMID: 16997776) Harm Reduct J. 2023 Feb 28;20(1):26. (PMID: 36855181) Drug Alcohol Depend. 2021 Aug 1;225:108759. (PMID: 34058540) Implement Sci. 2018 Nov 16;13(1):137. (PMID: 30442174) Implement Res Pract. 2022 Apr 11;3:26334895221089266. (PMID: 37091108) MMWR Morb Mortal Wkly Rep. 2021 Apr 09;70(14):519-522. (PMID: 33830988) NCHS Data Brief. 2022 Dec;(457):1-8. (PMID: 36598401) MMWR Morb Mortal Wkly Rep. 2015 Jun 19;64(23):631-5. (PMID: 26086633) J Urban Health. 2010 Dec;87(6):931-41. (PMID: 20967505) Addiction. 2005 Dec;100(12):1823-31. (PMID: 16367983) MMWR Morb Mortal Wkly Rep. 2020 Aug 21;69(33):1117-1121. (PMID: 32817603) Lancet. 2019 Jan 26;393(10169):316-318. (PMID: 30696566) J Urban Health. 2005 Jun;82(2):303-11. (PMID: 15872192) BMJ Qual Saf. 2016 Apr;25(4):257-64. (PMID: 26303644) Harm Reduct J. 2022 May 28;19(1):55. (PMID: 35643444) BMJ. 2013 Jan 30;346:f174. (PMID: 23372174) Implement Res Pract. 2020 Jan-Dec;1:. (PMID: 36189179) Addiction. 2008 Mar;103(3):379-86. (PMID: 18269360) Drug Alcohol Depend. 2015 Sep 1;154:283-6. (PMID: 26143300) Implement Sci. 2010 Oct 13;5:75. (PMID: 20942951) Addiction. 2013 Jun;108(6):1145-57. (PMID: 23316787) Eur J Emerg Med. 2004 Feb;11(1):19-23. (PMID: 15167188) Ann Emerg Med. 2007 Feb;49(2):172-7. (PMID: 17141138) |
معلومات مُعتمدة: | R01 DA046867 United States DA NIDA NIH HHS; 1R01DA055277-01 United States DA NIDA NIH HHS |
فهرسة مساهمة: | Keywords: Implementation science; Implementation strategy; Overdose education and naloxone distribution; Syringe services programs |
سلسلة جزيئية: | ClinicalTrials.gov NCT03924505 |
المشرفين على المادة: | 36B82AMQ7N (Naloxone) 0 (Narcotic Antagonists) |
تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
مُعرف محوري في PubMed: | PMC10900734 |
DOI: | 10.1186/s13012-024-01354-y |
PMID: | 38419058 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1748-5908 |
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DOI: | 10.1186/s13012-024-01354-y |