دورية أكاديمية
أعرض في EDS

Organize and mobilize for implementation effectiveness to improve overdose education and naloxone distribution from syringe services programs: a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Organize and mobilize for implementation effectiveness to improve overdose education and naloxone distribution from syringe services programs: a randomized controlled trial.
المؤلفون: Lambdin BH; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA. blambdin@rti.org.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. blambdin@rti.org.; Department of Global Health, University of Washington, Seattle, WA, USA. blambdin@rti.org., Bluthenthal RN; Keck Medicine, Department of Population and Public Health Sciences, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA., Garner BR; Department of Internal Medicine, College of Medicine, The Ohio State University, 370 W. 9Th Avenue, Columbus, OH, 43210, USA., Wenger LD; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Browne EN; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Morris T; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Ongais L; San Francisco AIDS Foundation, 1035 Market Street, 4Th Floor, San Francisco, CA, 94103, USA., Megerian CE; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA., Kral AH; RTI International, 2150 Shattuck Avenue, 8Th Floor, Berkeley, CA, 94704, USA.
المصدر: Implementation science : IS [Implement Sci] 2024 Feb 28; Vol. 19 (1), pp. 22. Date of Electronic Publication: 2024 Feb 28.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101258411 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-5908 (Electronic) Linking ISSN: 17485908 NLM ISO Abbreviation: Implement Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Opiate Overdose*/drug therapy , Drug Overdose*/drug therapy , Drug Overdose*/prevention & control , Opioid-Related Disorders*/drug therapy, Humans ; United States ; Naloxone/therapeutic use ; Health Education ; United States Department of Veterans Affairs ; Narcotic Antagonists/therapeutic use
مستخلص: Background: The United States (US) continues to face decades-long increases in opioid overdose fatalities. As an opioid overdose reversal medication, naloxone can dramatically reduce opioid overdose mortality rates when distributed to people likely to experience or witness an opioid overdose and packaged with education on its use, known as overdose education and naloxone distribution (OEND). Syringe services programs (SSPs) are ideal venues for OEND with staff who are culturally competent in providing services for people who are at risk of experiencing or observing an opioid overdose. We carried out a randomized controlled trial of SSPs to understand the effectiveness of the organize and mobilize for implementation effectiveness (OMIE) approach at improving OEND implementation effectiveness within SSPs.
Methods: Using simple randomization, 105 SSPs were enrolled into the trial and assigned to one of two study arms - (1) dissemination of OEND best practice recommendations (Control SSPs) or the OMIE approach along with dissemination of the OEND best practice recommendations (i.e., OMIE SSPs). OMIE SSPs could participate in 60-min OMIE sessions once a month for up to 12 months. At 12-month post-baseline, 102 of 105 SSPs (97%) responded to the follow-up survey.
Results: The median number of sessions completed by OMIE SSPs was 10. Comparing OMIE SSPs to control SSPs, we observed significant increases in the number of participants receiving naloxone (incidence rate ratio: 2.15; 95% CI: 1.42, 3.25; p < 0.01) and the rate of naloxone doses distributed per SSP participant (adjusted incidence rate ratio: 1.97; 95% CI: 1.18, 3.30; p = 0.01). We observed no statistically significant difference in the number of adopted best practices between conditions (difference in means 0.2, 95% CI: - 0.7, 1.0; p = 0.68). We also observed a threshold effect where SSPs receiving a higher OMIE dose had greater effect sizes with regard to the number of people given naloxone and the number of naloxone doses distributed.
Conclusions: In conclusion, the multifaceted OMIE approach was effective at increasing naloxone distribution from SSPs, despite substantial external shocks during the trial. These findings have major implications for addressing the overdose crisis, which has continued unabated for decades.
Trial Registration: ClinicalTrials.gov, NCT03924505 . Registered 19 April 2019.
(© 2024. The Author(s).)
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معلومات مُعتمدة: R01 DA046867 United States DA NIDA NIH HHS; 1R01DA055277-01 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: Implementation science; Implementation strategy; Overdose education and naloxone distribution; Syringe services programs
سلسلة جزيئية: ClinicalTrials.gov NCT03924505
المشرفين على المادة: 36B82AMQ7N (Naloxone)
0 (Narcotic Antagonists)
تواريخ الأحداث: Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC10900734
DOI: 10.1186/s13012-024-01354-y
PMID: 38419058
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-5908
DOI:10.1186/s13012-024-01354-y