دورية أكاديمية
أعرض في EDS

MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs.

التفاصيل البيبلوغرافية
العنوان: MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs.
المؤلفون: Olayemi A; Natural History Museum, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria., Schmid DW; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany., Fleischer R; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany., Wilhelm K; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany., Heni AC; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany., Mueller-Klein N; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany., Haikukutu L; Department of Wildlife Management, Sokoine University of Agriculture, Morogoro, Tanzania., Fichet-Calvet E; Department of Zoonoses Control, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Günther S; Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Sommer S; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Feb 29; Vol. 18 (2), pp. e0011984. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Lassa virus*/genetics , Lassa Fever*/genetics , Lassa Fever*/veterinary, Animals ; Humans ; Alleles ; Antibody Formation ; Kinetics ; Immunoglobulin G
مستخلص: West African Mastomys rodents are the primary reservoir of the zoonotic Lassa virus (LASV). The virus causes haemorrhagic Lassa fever and considerable mortality in humans. To date, the role of Mastomys immunogenetics in resistance to, and persistence of, LASV infections is largely unknown. Here, we investigated the role of Major Histocompatibility Complex class I (MHC-I) on LASV infection status (i.e., active vs. cleared infection, determined via PCR and an immunofluorescence assay on IgG antibodies, respectively) in Mastomys natalensis and M. erythroleucus sampled within southwestern Nigeria. We identified more than 190 and 90 MHC-I alleles by Illumina high throughput-sequencing in M. natalensis and M. erythroleucus, respectively, with different MHC allele compositions and frequencies between LASV endemic and non-endemic sites. In M. natalensis, the MHC allele ManaMHC-I*006 was negatively associated with active infections (PCR-positive) and positively associated with cleared infections (IgG-positive) simultaneously, suggesting efficient immune responses that facilitate LASV clearance in animals carrying this allele. Contrarily, alleles ManaMHC-I*008 and ManaMHC-I*021 in M. natalensis, and MaerMHC-I*008 in M. erythroleucus, were positively associated with active infection, implying susceptibility. Alleles associated with susceptibility shared a glutamic acid at the positively selected codon 57, while ManaMHC-I*006 featured an arginine. There was no link between number of MHC alleles per Mastomys individual and LASV prevalence. Thus, specific alleles, but not MHC diversity per se, seem to mediate antibody responses to viremia. We conclude that co-evolution with LASV likely shaped the MHC-I diversity of the main LASV reservoirs in southwestern Nigeria, and that information on reservoir immunogenetics may hold insights into transmission dynamics and zoonotic spillover risks.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Olayemi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
References: Methods Mol Biol. 2000;132:365-86. (PMID: 10547847)
Bull World Health Organ. 1975;52(4-6):429-36. (PMID: 821624)
One Health. 2021 Aug 27;13:100317. (PMID: 34522759)
Virology. 2015 Feb;476:249-256. (PMID: 25559385)
NPJ Vaccines. 2020 Jan 3;5(1):2. (PMID: 31908851)
Ecohealth. 2017 Sep;14(3):463-473. (PMID: 28616660)
J Med Chem. 1998 Jul 2;41(14):2481-91. (PMID: 9651153)
Antiviral Res. 2018 Nov;159:63-67. (PMID: 30261226)
Comp Med. 2003 Feb;53(1):70-4. (PMID: 12625509)
Sci Rep. 2015 May 29;5:10445. (PMID: 26022445)
Emerg Microbes Infect. 2020 Dec;9(1):1055-1064. (PMID: 32459576)
Trends Genet. 2020 Apr;36(4):298-311. (PMID: 32044115)
Trans R Soc Trop Med Hyg. 2015 Aug;109(8):483-92. (PMID: 26085474)
BMJ. 1988 Sep 3;297(6648):584-7. (PMID: 3139220)
Viruses. 2021 May 07;13(5):. (PMID: 34067011)
Br Med J. 1977 May 28;1(6073):1399-402. (PMID: 861652)
Front Zool. 2005 Oct 20;2:16. (PMID: 16242022)
Mol Biol Evol. 2013 Dec;30(12):2723-4. (PMID: 24105918)
Emerg Infect Dis. 2011 Oct;17(10):1921-4. (PMID: 22000372)
Mol Ecol. 2009 Jan;18(1):80-92. (PMID: 19140966)
Infect Genet Evol. 2018 Sep;63:380-390. (PMID: 28882517)
PLoS Comput Biol. 2021 Mar 3;17(3):e1008811. (PMID: 33657095)
Immunogenetics. 2010 Jan;62(1):59-64. (PMID: 19953242)
Bull World Health Organ. 1975;52(4-6):637-44. (PMID: 1085219)
Emerg Infect Dis. 2016 Apr;22(4):694-7. (PMID: 26982388)
IJID Reg. 2022 Jun 29;4:105-110. (PMID: 35880003)
Nature. 2023 Jan;613(7943):340-344. (PMID: 36384167)
PLoS Negl Trop Dis. 2018 Feb 22;12(2):e0006187. (PMID: 29470486)
Immunol Today. 1996 Jun;17(6):261-6. (PMID: 8962628)
Ann Clin Microbiol Antimicrob. 2021 Apr 24;20(1):29. (PMID: 33894784)
Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):. (PMID: 33822740)
BMC Evol Biol. 2017 Jul 05;17(1):159. (PMID: 28679358)
Parasit Vectors. 2017 Apr 27;10(1):210. (PMID: 28449693)
Nature. 2020 Aug;584(7821):398-402. (PMID: 32759999)
Vector Borne Zoonotic Dis. 2014 Sep;14(9):665-74. (PMID: 25229705)
Viruses. 2020 Mar 14;12(3):. (PMID: 32183319)
PLoS Negl Trop Dis. 2014 Mar 20;8(3):e2748. (PMID: 24651047)
Nat Rev Microbiol. 2023 Feb;21(2):87-96. (PMID: 36097163)
BMC Evol Biol. 2009 Nov 23;9:269. (PMID: 19930637)
Science. 1974 Jul 19;185(4147):263-5. (PMID: 4833828)
Parasit Vectors. 2018 Jul 13;11(1):416. (PMID: 30005641)
PLoS One. 2012;7(1):e30222. (PMID: 22291920)
Expert Rev Mol Med. 2003 Feb 24;5(7):1-17. (PMID: 14987410)
Immunogenetics. 2004 Jun;56(3):178-91. (PMID: 15138734)
Crit Rev Immunol. 1997;17(2):179-224. (PMID: 9094452)
Proc Biol Sci. 2020 Apr 8;287(1924):20192736. (PMID: 32259475)
Front Zool. 2018 Apr 20;15:15. (PMID: 29721030)
Mol Biol Evol. 2005 May;22(5):1254-9. (PMID: 15703235)
BMC Genet. 2010 Oct 15;11:94. (PMID: 20950446)
Mol Biol Evol. 2019 Dec 1;36(12):2805-2812. (PMID: 31424545)
Immunogenetics. 2007 May;59(5):417-26. (PMID: 17351770)
Vector Borne Zoonotic Dis. 2011 Aug;11(8):1125-31. (PMID: 21142956)
Evolution. 2022 Sep;76(9):2067-2075. (PMID: 35909235)
Emerg Infect Dis. 2009 Dec;15(12):2008-12. (PMID: 19961688)
Immunogenetics. 2019 Sep;71(8-9):575-587. (PMID: 31520134)
Trends Immunol. 2018 May;39(5):367-379. (PMID: 29396014)
Proc Biol Sci. 2013 Mar 20;280(1759):20130134. (PMID: 23516242)
Science. 2003 Sep 5;301(5638):1343. (PMID: 12958352)
Mol Ecol Resour. 2021 Apr;21(3):982-998. (PMID: 33113273)
Emerg Microbes Infect. 2023 Dec;12(1):2219350. (PMID: 37288752)
Mol Ecol. 2022 Jun;31(12):3400-3415. (PMID: 35510766)
Mol Ecol. 2022 Jun;31(12):3342-3359. (PMID: 35510794)
Immunogenetics. 1992;37(1):29-38. (PMID: 1428009)
Immunogenetics. 2003 Jun;55(3):133-140. (PMID: 12743657)
J Virol. 2006 Sep;80(17):8351-61. (PMID: 16912286)
Poult Sci. 1992 Nov;71(11):1801-6. (PMID: 1437966)
Proc Biol Sci. 2012 Feb 7;279(1728):577-84. (PMID: 21733902)
Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16705-10. (PMID: 21949385)
Immunogenetics. 2004 Sep;56(6):427-37. (PMID: 15322775)
Sci Rep. 2016 May 03;6:25280. (PMID: 27140942)
المشرفين على المادة: 0 (Immunoglobulin G)
تواريخ الأحداث: Date Created: 20240229 Date Completed: 20240304 Latest Revision: 20240304
رمز التحديث: 20240304
مُعرف محوري في PubMed: PMC10903922
DOI: 10.1371/journal.pntd.0011984
PMID: 38421939
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0011984