دورية أكاديمية
Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways.
| العنوان: | Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways. |
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| المؤلفون: | Curaj A; Institute of Molecular Cardiovascular Research, RWTH Aachen University, Germany (A.C., K.Q., Z.W., V.J., J.J.)., Vanholder R; Department of Internal Medicine and Pediatrics, Nephrology Section, University Hospital, Ghent, Belgium (R.V.)., Loscalzo J; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.L.)., Quach K; Institute of Molecular Cardiovascular Research, RWTH Aachen University, Germany (A.C., K.Q., Z.W., V.J., J.J.)., Wu Z; Institute of Molecular Cardiovascular Research, RWTH Aachen University, Germany (A.C., K.Q., Z.W., V.J., J.J.)., Jankowski V; Institute of Molecular Cardiovascular Research, RWTH Aachen University, Germany (A.C., K.Q., Z.W., V.J., J.J.)., Jankowski J; Institute of Molecular Cardiovascular Research, RWTH Aachen University, Germany (A.C., K.Q., Z.W., V.J., J.J.).; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, the Netherlands (J.J.).; Aachen-Maastricht Institute for Cardiorenal Disease, RWTH Aachen University, Aachen, Germany (J.J.). |
| المصدر: | Circulation research [Circ Res] 2024 Mar; Vol. 134 (5), pp. 592-613. Date of Electronic Publication: 2024 Feb 29. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, MD : Lippincott Williams & Wilkins Original Publication: Baltimore, Md. Grune & Stratton. |
| مواضيع طبية MeSH: | Cardio-Renal Syndrome* , Vascular Diseases*, Humans ; Heart ; Kidney/metabolism ; Signal Transduction ; Lung/metabolism |
| مستخلص: | The crosstalk of the heart with distant organs such as the lung, liver, gut, and kidney has been intensively approached lately. The kidney is involved in (1) the production of systemic relevant products, such as renin, as part of the most essential vasoregulatory system of the human body, and (2) in the clearance of metabolites with systemic and organ effects. Metabolic residue accumulation during kidney dysfunction is known to determine cardiovascular pathologies such as endothelial activation/dysfunction, atherosclerosis, cardiomyocyte apoptosis, cardiac fibrosis, and vascular and valvular calcification, leading to hypertension, arrhythmias, myocardial infarction, and cardiomyopathies. However, this review offers an overview of the uremic metabolites and details their signaling pathways involved in cardiorenal syndrome and the development of heart failure. A holistic view of the metabolites, but more importantly, an exhaustive crosstalk of their known signaling pathways, is important for depicting new therapeutic strategies in the cardiovascular field. Competing Interests: Disclosures None. |
| فهرسة مساهمة: | Keywords: cardio-renal syndrome; kidney; kidney-heart crosstalk; signal transduction; uremic toxins |
| تواريخ الأحداث: | Date Created: 20240229 Date Completed: 20240304 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| DOI: | 10.1161/CIRCRESAHA.123.324001 |
| PMID: | 38422175 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4571 |
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| DOI: | 10.1161/CIRCRESAHA.123.324001 |