دورية أكاديمية
Gestational and Developmental Contributors of Pediatric MASLD.
| العنوان: | Gestational and Developmental Contributors of Pediatric MASLD. |
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| المؤلفون: | Mouzaki M; Divisions of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio., Woo JG; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. |
| المصدر: | Seminars in liver disease [Semin Liver Dis] 2024 Feb; Vol. 44 (1), pp. 43-53. Date of Electronic Publication: 2024 Feb 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: United States NLM ID: 8110297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8971 (Electronic) Linking ISSN: 02728087 NLM ISO Abbreviation: Semin Liver Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Thieme Original Publication: New York, N.Y. : Thieme-Stratton, c1981- |
| مواضيع طبية MeSH: | Obesity* , Fatty Liver*, Infant ; Female ; Pregnancy ; Child ; Humans ; Environmental Exposure ; Exercise ; Weight Gain |
| مستخلص: | Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is common and can be seen as early as in utero . A growing body of literature suggests that gestational and early life exposures modify the risk of MASLD development in children. These include maternal risk factors, such as poor cardiometabolic health (e.g., obesity, gestational diabetes, rapid weight gain during pregnancy, and MASLD), as well as periconceptional dietary exposures, degree of physical activity, intestinal microbiome, and smoking. Paternal factors, such as diet and obesity, also appear to play a role. Beyond gestation, early life dietary exposures, as well as the rate of infant weight gain, may further modify the risk of future MASLD development. The mechanisms linking parental health and environmental exposures to pediatric MASLD are complex and not entirely understood. In conclusion, investigating gestational and developmental contributors to MASLD is critical and may identify future interventional targets for disease prevention. Competing Interests: None declared. (Thieme. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20240229 Date Completed: 20240418 Latest Revision: 20240418 |
| رمز التحديث: | 20240418 |
| DOI: | 10.1055/s-0044-1782210 |
| PMID: | 38423068 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-8971 |
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| DOI: | 10.1055/s-0044-1782210 |