دورية أكاديمية
أعرض في EDS

Increased levels of circulating soluble CD226 in multiple sclerosis.

التفاصيل البيبلوغرافية
العنوان: Increased levels of circulating soluble CD226 in multiple sclerosis.
المؤلفون: Kari S; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Bucciarelli F; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Angles T; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Oster AC; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Cauboue P; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Laviolette K; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Mougenot M; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Morandi E; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Bernard I; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Pignolet B; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France.; CRC-SEP, Neurosciences Department, Toulouse University Hospital, Toulouse, France., Bost C; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France.; Immunology Department Laboratory, Institut Fédératif de Biologie, Toulouse University Hospital Center, Toulouse, France., Thomas J; CNRS UMR-5284, INSERM U-1314, MeLiS, Institut NeuroMyoGène, Universite de Lyon-Université Claude Bernard Lyon 1, Lyon, France., Nogueira L; Laboratory of Cell Biology and Cytology, Toulouse University Hospital, Toulouse, France., Saoudi A; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Liblau R; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France., Astier AL; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse Cedex 3, France.
المصدر: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2024 May; Vol. 30 (6), pp. 654-663. Date of Electronic Publication: 2024 Feb 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مواضيع طبية MeSH: Antigens, Differentiation, T-Lymphocyte*/blood , Dendritic Cells*/immunology , Multiple Sclerosis*/blood , Multiple Sclerosis*/immunology , Neuromyelitis Optica*/blood , Neuromyelitis Optica*/immunology, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Alzheimer Disease/blood ; Alzheimer Disease/immunology ; Biomarkers/blood ; T-Lymphocytes/immunology ; Aged, 80 and over
مستخلص: Background: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown.
Objective: To investigate the presence and functional implications of sCD226 in persons with multiple sclerosis (pwMS) and other neurological diseases.
Methods: The mechanisms of sCD226 production were first investigated by analyzing CD226 surface expression levels and supernatants of CD3/CD226-coactivated T cells. The role of sCD226 on dendritic cell maturation was evaluated. The concentration of sCD226 in the sera from healthy donors (HD), pwMS, neuromyelitis optica (NMO), and Alzheimer's disease (AD) was measured.
Results: CD3/CD226-costimulation induced CD226 shedding. Addition of sCD226 to dendritic cells during their maturation led to an increased production of the pro-inflammatory cytokine interleukin (IL)-23. We observed a significant increase in sCD226 in sera from pwMS and NMO compared to HD and AD. In MS, levels were increased in both relapsing-remitting multiple sclerosis (RRMS) and secondary-progressive multiple sclerosis (SPMS) compared to clinically isolated syndrome (CIS).
Conclusion: Our data suggest that T-cell activation leads to release of sCD226 that could promote inflammation and raises the possibility of using sCD226 as a biomarker for neuroinflammation.
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
فهرسة مساهمة: Keywords: CD4+ T cells; Multiple sclerosis; biomarker; dendritic cells; soluble CD226
المشرفين على المادة: 0 (Antigens, Differentiation, T-Lymphocyte)
0 (Biomarkers)
0 (CD226 antigen)
تواريخ الأحداث: Date Created: 20240301 Date Completed: 20240506 Latest Revision: 20240509
رمز التحديث: 20240509
DOI: 10.1177/13524585241234489
PMID: 38424741
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-0970
DOI:10.1177/13524585241234489