دورية أكاديمية
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant C. albicans and methicillin-resistant S. aureus in catheters.
| العنوان: | Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant C. albicans and methicillin-resistant S. aureus in catheters. |
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| المؤلفون: | da Silva CR; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil., Sá LGDAV; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil., Andrade Neto JB; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil., Barroso FDD; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil., Cabral VPF; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil., Rodrigues DS; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil., da Silva LJ; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil., Lima ISP; Departament of Pharmacology, School of Medicine, Federal University of Ceará, Barbalha, CE, Brazil., Pérez L; Department of Surfactants and Nanobiotechnology, IQAC-CSIC, Barcelona, Spain., Ramos da Silva A; Department of Surfactants and Nanobiotechnology, IQAC-CSIC, Barcelona, Spain., Moreira DR; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Fortaleza, CE, Brazil., Ricardo NMPS; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Fortaleza, CE, Brazil., Nobre HV Júnior; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Center of Drug Research and Development, Federal University of Ceará, Fortaleza, CE, Brazil. |
| المصدر: | Biofouling [Biofouling] 2024 Feb; Vol. 40 (2), pp. 165-176. Date of Electronic Publication: 2024 Feb 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9200331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2454 (Electronic) Linking ISSN: 08927014 NLM ISO Abbreviation: Biofouling Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Abingdon, Oxford : Taylor & Francis Original Publication: Chur ; New York : Harwood Academic Publishers, c1988- |
| مواضيع طبية MeSH: | Methicillin-Resistant Staphylococcus aureus* , Anti-Infective Agents*/pharmacology, Fluconazole/pharmacology ; Candida albicans ; Staphylococcus aureus ; Methicillin Resistance ; Biofilms ; Poloxamer/pharmacology ; Microbial Sensitivity Tests ; Catheters ; Anti-Bacterial Agents/pharmacology |
| مستخلص: | Dual-species biofilms formed by Candida albicans and Staphylococcus aureus have high virulence and drug resistance. In this context, biosurfactants produced by Pseudomonas aeruginosa have been widely studied, of which a new derivative (RLmix_Arg) stands out for possible application in formulations. The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus , by reducing the cell viability of mixed biofilms of FRCA and MRSA, and preventing their formation in a peripheral venous catheter. The incorporation of this biosurfactant in the Pluronic F-127 gel considerably enhanced its antibiofilm activity. Thus, RLmix_Arg has potential application in gels for impregnation in peripheral venous catheters, helping to prevent development of dual-species biofilms of FRCA and MRSA. |
| فهرسة مساهمة: | Keywords: Biosurfactant; Candida albicans; Staphylococcus aureus; biofilm; catheter; gel |
| المشرفين على المادة: | 8VZV102JFY (Fluconazole) 106392-12-5 (Poloxamer) 0 (Anti-Infective Agents) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240301 Date Completed: 20240409 Latest Revision: 20240409 |
| رمز التحديث: | 20240409 |
| DOI: | 10.1080/08927014.2024.2324028 |
| PMID: | 38425095 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1029-2454 |
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| DOI: | 10.1080/08927014.2024.2324028 |