دورية أكاديمية
β-glucans from Agaricus bisporus mushroom products drive Trained Immunity.
| العنوان: | β-glucans from Agaricus bisporus mushroom products drive Trained Immunity. |
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| المؤلفون: | Case S; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., O'Brien T; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., Ledwith AE; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., Chen S; NatPro Centre, School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland., Horneck Johnston CJH; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., Hackett EE; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., O'Sullivan M; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., Charles-Messance H; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland., Dempsey E; School of Genetics and Microbiology, Trinity College, Dublin, Ireland., Yadav S; MBio, Monaghan, Ireland., Wilson J; MBio, Monaghan, Ireland., Corr SC; School of Genetics and Microbiology, Trinity College, Dublin, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Nagar S; NatPro Centre, School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland., Sheedy FJ; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.; NatPro Centre, School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland. |
| المصدر: | Frontiers in nutrition [Front Nutr] 2024 Feb 15; Vol. 11, pp. 1346706. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]- |
| مستخلص: | Introduction: Macrofungi, such as edible mushrooms, have been used as a valuable medical resource for millennia as a result of their antibacterial and immuno-modulatory components. Mushrooms contain dietary fibers known as β-glucans, a class of polysaccharides previously linked to the induction of Trained Immunity. However, little is known about the ability of mushroom-derived β-glucans to induce Trained Immunity. Methods & Results: Using various powdered forms of the white button mushroom (Agaricus bisporus), we found that mouse macrophages pre-treated with whole mushroom powder (WMP) displayed enhanced responses to restimulation with TLR ligands, being particularly sensitive to Toll-like receptor (TLR)-2 stimulation using synthetic lipopeptides. This trained response was modest compared to training observed with yeast-derived β-glucans and correlated with the amount of available β-glucans in the WMP. Enriching for β-glucans content using either a simulated in-vitro digestion or chemical fractionation retained and boosted the trained response with WMP, respectively. Importantly, both WMP and digested-WMP preparations retained β-glucans as identified by nuclear magnetic resonance analysis and both displayed the capacity to train human monocytes and enhanced responses to restimulation. To determine if dietary incorporation of mushroom products can lead to Trained Immunity in myeloid cells in vivo, mice were given a regimen of WMP by oral gavage prior to sacrifice. Flow cytometric analysis of bone-marrow progenitors indicated alterations in hematopoietic stem and progenitor cells population dynamics, with shift toward myeloid-committed multi-potent progenitor cells. Mature bone marrow-derived macrophages derived from these mice displayed enhanced responses to restimulation, again particularly sensitive to TLR2. Discussion: Taken together, these data demonstrate that β-glucans from common macrofungi can train innate immune cells and could point to novel ways of delivering bio-available β-glucans for education of the innate immune system. Competing Interests: JW and SY are scientists at Monaghan Mushrooms who supplied the powdered mushroom products for this study and employed by MBio. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Case, O'Brien, Ledwith, Chen, Horneck Johnston, Hackett, O'Sullivan, Charles-Messance, Dempsey, Yadav, Wilson, Corr, Nagar and Sheedy.) |
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| فهرسة مساهمة: | Keywords: Trained Immunity; digestion; immunometabolism; mushroom; β-glucan |
| تواريخ الأحداث: | Date Created: 20240301 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| مُعرف محوري في PubMed: | PMC10902450 |
| DOI: | 10.3389/fnut.2024.1346706 |
| PMID: | 38425482 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-861X |
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| DOI: | 10.3389/fnut.2024.1346706 |