تقرير
Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia.
| العنوان: | Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia. |
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| المؤلفون: | Blumel L; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Bernardi F; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Picard D; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Diaz JT; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Jepsen VH; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Hasselmann R; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Schliehe-Diecks J; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Bartl J; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf, Germany; Group for Interdisciplinary Neurobiology and Immunology - INI-research, Institute of Zoology, University of Hamburg, Hamburg., Qin N; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Bornhauser B; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich., Bhatia S; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Marovka B; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich., Marsaud V; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Dingli F; Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris., Loew D; Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris., Stanulla M; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover., Bourqin JP; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Remke M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Ayrault O; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Fischer U; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf. ute.fischer@med.uni-duesseldorf.de. |
| المصدر: | Haematologica [Haematologica] 2024 Jul 01; Vol. 109 (7), pp. 2290-2296. Date of Electronic Publication: 2024 Jul 01. |
| نوع المنشور: | Letter; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Pavia, Italy : Ferrata Storti Foundation Original Publication: Pavia [etc.] |
| مواضيع طبية MeSH: | Oncogene Proteins, Fusion*/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/pathology, Humans ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Pre-B-Cell Leukemia Transcription Factor 1/genetics ; Pre-B-Cell Leukemia Transcription Factor 1/metabolism ; Proteogenomics/methods ; Translocation, Genetic |
| References: | Cancer Discov. 2012 Nov;2(11):1004-23. (PMID: 23107779) Blood. 2013 Jan 17;121(3):485-8. (PMID: 23212523) Cancer Cell. 2015 Mar 9;27(3):409-25. (PMID: 25759025) Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552. (PMID: 34723319) Haematologica. 2019 Apr;104(4):738-748. (PMID: 30381299) Nat Commun. 2019 Apr 3;10(1):1519. (PMID: 30944321) Blood Cancer J. 2014 Feb 14;4:e181. (PMID: 24531445) Blood. 2017 Mar 2;129(9):1155-1165. (PMID: 28031181) Transl Oncol. 2020 Oct;13(10):100817. (PMID: 32563910) Eur J Med Chem. 2022 Feb 5;229:114051. (PMID: 34952433) Nat Rev Drug Discov. 2022 Sep;21(9):637-654. (PMID: 35351998) Leukemia. 2017 Jan;31(1):51-57. (PMID: 27461063) Nat Genet. 2015 Sep;47(9):1020-1029. (PMID: 26214592) Br J Haematol. 2008 Sep;142(5):802-7. (PMID: 18573112) Cancer Cell. 2019 Dec 9;36(6):630-644.e9. (PMID: 31735627) |
| المشرفين على المادة: | 0 (Basic Helix-Loop-Helix Transcription Factors) 0 (Oncogene Proteins, Fusion) 0 (Pre-B-Cell Leukemia Transcription Factor 1) 0 (TCF3 protein, human) |
| تواريخ الأحداث: | Date Created: 20240301 Date Completed: 20240701 Latest Revision: 20240817 |
| رمز التحديث: | 20240818 |
| مُعرف محوري في PubMed: | PMC11215373 |
| DOI: | 10.3324/haematol.2023.283928 |
| PMID: | 38426288 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1592-8721 |
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| DOI: | 10.3324/haematol.2023.283928 |