دورية أكاديمية
Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer.
| العنوان: | Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer. |
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| المؤلفون: | Tian Y; Department of Gastroenterology, Lanzhou University Second Hospital, Cuiyingmen No. 82, Chengguan District, Lanzhou, 730030, Gansu Province, China., Xie Y; The Gastroenterology Clinical Medical Center of Hainan Province, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou City, China., Bai F; The Gastroenterology Clinical Medical Center of Hainan Province, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou City, China. baifeihu@sohu.com., Wang J; Department of Gastroenterology, 986 Hospital, Xijing Hospital, Air Force Military Medical University, No. 269, Youyi East Road, Xi'an, Shaanxi Province, 710089, China. wangjundoctor@aliyun.com., Zhang D; Department of Gastroenterology, Lanzhou University Second Hospital, Cuiyingmen No. 82, Chengguan District, Lanzhou, 730030, Gansu Province, China. zhangdk8616@126.com. |
| المصدر: | Journal of gastrointestinal cancer [J Gastrointest Cancer] 2024 Jun; Vol. 55 (2), pp. 900-912. Date of Electronic Publication: 2024 Mar 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101479627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-6636 (Electronic) NLM ISO Abbreviation: J Gastrointest Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2010- : New York : Springer Science+Business Media Original Publication: New York, NY : Humana Press |
| مواضيع طبية MeSH: | Stomach Neoplasms*/genetics , Stomach Neoplasms*/pathology , Stomach Neoplasms*/mortality , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , CLOCK Proteins*/genetics, Humans ; Prognosis ; Circadian Clocks/genetics ; Period Circadian Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Computational Biology ; Circadian Rhythm/genetics ; Cell Cycle Proteins ; Intracellular Signaling Peptides and Proteins ; Nuclear Receptor Subfamily 1, Group D, Member 1 |
| مستخلص: | Background: Gastric cancer is one of the major public health problems worldwide. Circadian rhythm disturbances driven by circadian clock genes play a role in the development of cancer. However, whether circadian clock genes can serve as potential therapeutic targets and prognostic biomarkers for gastric cancer remains elusive. Methods: In this study, we comprehensively analyzed the potential relationship between circadian clock genes and gastric cancer using online bioinformatics databases such as GEPIA, cBioPortal, STRING, GeneMANIA, Metascape, TIMER, TRRUST, and GEDS. Results: Biological clock genes are expressed differently in human tumors. Compared with normal tissues, only PER1, CLOCK, and TIMELESS expression differences were statistically significant in gastric cancer (p < 0.05). PER1 (p = 0.0169) and CLOCK (p = 0.0414) were associated with gastric cancer pathological stage (p < 0.05). Gastric cancer patients with high expression of PER1 (p = 0.0028) and NR1D1 (p = 0.016) had longer overall survival, while those with high expression of PER1 (p = 0.042) and NR1D1 (p = 0.016) had longer disease-free survival. The main function of the biological clock gene is related to the circadian rhythms and melatonin metabolism and effects. CLOCK, NPAS2, and KAT2B were key transcription factors for circadian clock genes. In addition, we also found important correlations between circadian clock genes and various immune cells in the gastric cancer microenvironment. Conclusions: This study may establish a new gastric cancer prognostic indicator based on the biological clock gene and develop new drugs for the treatment of gastric cancer using biological clock gene targets. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| معلومات مُعتمدة: | 2021818 Hainan Province Clinical Medical Center; 2022136 the specific research fund of The Innovation Platform for Academicians of Hainan Province; 22A200078 Hainan Provincial Health Industry Research Project; lzuyxcx-2022-181 Medical Innovation and Development Project of Lanzhou University |
| فهرسة مساهمة: | Keywords: Bioinformatics; Biological clock genes; Gastric adenocarcinoma; Genetic alterations; Signaling pathways; Tumor microenvironment |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) EC 2.3.1.48 (CLOCK Proteins) 0 (PER1 protein, human) EC 2.3.1.48 (CLOCK protein, human) 0 (Period Circadian Proteins) 0 (NR1D1 protein, human) 0 (TIMELESS protein, human) 0 (Cell Cycle Proteins) 0 (Intracellular Signaling Peptides and Proteins) 0 (Nuclear Receptor Subfamily 1, Group D, Member 1) |
| تواريخ الأحداث: | Date Created: 20240301 Date Completed: 20240619 Latest Revision: 20240619 |
| رمز التحديث: | 20240619 |
| DOI: | 10.1007/s12029-024-01028-4 |
| PMID: | 38427147 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1941-6636 |
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| DOI: | 10.1007/s12029-024-01028-4 |