دورية أكاديمية

Impacts of Omega-3 Fatty Acids, Natural Elixirs for Neuronal Health, on Brain Development and Functions.

التفاصيل البيبلوغرافية
العنوان: Impacts of Omega-3 Fatty Acids, Natural Elixirs for Neuronal Health, on Brain Development and Functions.
المؤلفون: Rao AS; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India., Nair A; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India., Nivetha K; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India., Ayesha B; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India., Hardi K; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India., Divya V; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India., Veena SM; Department of Biotechnology, Sapthagiri College of Engineering, Bangalore, India., Anantharaju KS; Department of Chemistry, Dayananda Sagar College of Engineering, Bangalore, India., More SS; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India.
المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2761, pp. 209-229.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,
مواضيع طبية MeSH: Fatty Acids, Omega-3*/pharmacology, Eicosapentaenoic Acid/pharmacology ; Docosahexaenoic Acids/pharmacology ; Fatty Acids, Unsaturated ; Fatty Acids ; Brain
مستخلص: Omega-3 fatty acids play a seminal role in maintaining the structural and functional integrity of the nervous system. These specialized molecules function as precursors for many lipid-based biological messengers. Also, studies suggest the role of these fatty acids in regulating healthy sleep cycles, cognitive ability, brain development, etc. Dietary intake of essential poly unsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are foundational to the optimal working of the nervous system. Besides regulating health, these biomolecules have great therapeutic value in treating several diseases, particularly nervous system diseases and disorders. Many recent studies conclusively demonstrated the beneficial effects of Omega-3 fatty acids in treating depression, neuropsychiatric disorders, neurodegenerative disorders, neurochemical disorders, and many other illnesses associated with the nervous system. This chapter summates the multifaceted role of poly unsaturated fatty acids, especially Omega-3 fatty acids (EPA and DHA), in the neuronal health and functioning. The importance of dietary intake of these essential fatty acids, their recommended dosages, bioavailability, the mechanism of their action, and therapeutic values are extensively discussed.
(© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
References: Brown TT, Jernigan TL (2012) Brain development during the preschool years. Neuropsychol Rev 22:313–233. (PMID: 23007644351163310.1007/s11065-012-9214-1)
Anderson V, Fenwick T, Manly T, Robertson I (1998) Attentional skills following traumatic brain injury in childhood: a componential analysis. Brain Inj 12:937–949. (PMID: 983902710.1080/026990598121990)
Barkley RA (2001) The executive functions and self-regulation: an evolutionary neuropsychological perspective. Neuropsychol Rev 11:1–29.
Kuratko CN, Barrett EC, Nelson EB, Norman S Jr (2013) The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. Nutrients 5(7):2777–2810. (PMID: 23877090373899910.3390/nu5072777)
Mitchell DC, Gawrisch K, Litman BJ, Salem N (1998) Why is docosahexaenoic acid essential for nervous system function? Biochem Soc Trans 26(3):365–370. https://doi.org/10.1042/bst0260365. (PMID: 10.1042/bst02603659765880)
Bowen RA, Clandinin MT (2002) Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium–potassium ATPase kinetics in developing rats. J Neurochem 83(4):764–774. (PMID: 1242134810.1046/j.1471-4159.2002.01156.x)
Bazan NG, Scott BL (1990) Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. Ups J Med Sci 48:97–107.
Sarkadi-Nagy E, Wijendram V, Diau GY, Chao AC, Hsieh AT, Turpeinen A, Brenna JT (2003) The influence of prematurity and long chain polyunsaturated supplementation in 4-week adjusted age baboon neonate brain and related tissues. Pediatr Res 54(2):244–252. (PMID: 1273638810.1203/01.PDR.0000072795.38990.F2)
Van Aerde JE, Wilke MS, Feldman M, Clandinin MT (2011) Accretion of lipid in the fetus and newborn. Accretion of lipid in the fetus and newborn. In: Fetal and neonatal physiology. WB Saunders, pp 454–470. (PMID: 10.1016/B978-1-4160-3479-7.10042-4)
Judge MP, Harel O, Lammi-Keefe CJ (2007) Maternal consumption of a docosahexaenoic acid–containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. Am J Clin Nutr 85(6):1572–1577. (PMID: 1755669510.1093/ajcn/85.6.1572)
Su KP (2009) Biological mechanism of antidepressant effect of omega–3 fatty acids: how does fish oil act as a ‘mind-body interface’? Neurosignals 17(2):144–152. (PMID: 1919040110.1159/000198167)
Khalid W, Gill P, Arshad MS, Ali A, Ranjha MMAN, Mukhtar S, Maqbool Z (2022) Functional behavior of DHA and EPA in the formation of babies brain at different stages of age, and protect from different brain-related diseases. Int J Food Prop 25(1):1021–1044. (PMID: 10.1080/10942912.2022.2070642)
Uauy R, Mena P, Rojas C (2000) Essential fatty acids in early life: structural and functional role. Proc Nutr Soc 59(1):3–15. (PMID: 1082816910.1017/S0029665100000021)
Dunstan J, Simmer K, Dixon G, Prescott SL (2008) Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 93(1):F45–F50. (PMID: 1718542310.1136/adc.2006.099085)
Drover J, Hoffman DR, Castaneda YS, Morale SE, Birch EE (2009) Three randomized controlled trials of early long-chain polyunsaturated fatty acid supplementation on means-end problem solving in 9-month-olds. Child Dev 80(5):1376–1384. (PMID: 19765006275731710.1111/j.1467-8624.2009.01339.x)
Colombo J, Gustafson KM, Gajewski BJ, Shaddy BJ, Kerling EH, Thodosoff JM, Carlson SE (2016) Prenatal DHA supplementation and infant attention. Pediatr Res 80(5):656–662. (PMID: 27362506516492610.1038/pr.2016.134)
Jensen CL, Voigt RG, Llorente AM, Peters SU, Prager TC, Zou YL, Heird WC (2010) Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. J Pediatr 157(6):900–905. (PMID: 2065554310.1016/j.jpeds.2010.06.006)
Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG (2000) A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 42(3):174–181. (PMID: 10755457)
Drover JR, Hoffman DR, Castaneda YS, Morale SE, Garfield S, Wheaton DH, Birch EE (2011) Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. Early Hum Dev 87(3):223–230. (PMID: 2129541710.1016/j.earlhumdev.2010.12.047)
Mohanty BP, Ganguly S, Mahanty A, Sankar TV, Anandan R, Chakraborty K, Sridhar N (2016) DHA and EPA content and fatty acid profile of 39 food fishes from India. Biomed Res Int 2016:4027437. (PMID: 27579313498907010.1155/2016/4027437)
Hernandez-Ledesma B, Hsieh CC, Martinez-Villaluenga C (2017) Food bioactive compounds against diseases of the 21st century. Biomed Res Int 75(1):3–9.
Kohler A, Sarkkinen E, Tapola N, Niskanen T, Bruheim I (2015) Bioavailability of fatty acids from krill oil, krill meal and fish oil in healthy subjects – a randomized, single-dose, cross-over trial. Lipids Health Dis 14:1–10. (PMID: 10.1186/s12944-015-0015-4)
Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arteburn LM (2007) Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 85(6):1457–1464. (PMID: 1755668010.1093/ajcn/85.6.1457)
Li J, Pora BL, Dong K, Hasjim J (2021) Health benefits of docosahexaenoic acid and its bioavailability: a review. Food Sci Nutr 9(9):5229–5243. (PMID: 34532031844144010.1002/fsn3.2299)
Lane K, Derbyshire E, Li W, Brennan C (2014) Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. Crit Rev Food Sci Nutr 54(5):572–579. (PMID: 2426153210.1080/10408398.2011.596292)
Marshall TA (2011) Dietary guidelines for Americans, 2010: an update. J Am Dental Assoc 142(6):654–656. (PMID: 10.14219/jada.archive.2011.0248)
Sposito AC, Caramelli B, Fonseca FA, Bertolami MC, Neto AA, Souza AD, Sociedade Brasileira de Cardiologia (2007) IV Brazilian guideline for dyslipidemia and atherosclerosis prevention: Department of Atherosclerosis of Brazilian Society of Cardiology. Arq Bras Cardiol 88:2–19. (PMID: 1751598210.1590/S0066-782X2007000700002)
Zanarini MC, Frankenburg FR (2003) Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study. Am J Psychiatry 160(1):167–169. (PMID: 1250581710.1176/appi.ajp.160.1.167)
Chang CY, Ke DS, Chen JY (2009) Essential fatty acids and human brain. Acta Neurol Taiwanica 18(4):231–241.
Checa-Ros A, D’Marco L (2022) Role of omega-3 fatty acids as non-photic zeitgebers and circadian clock synchronizers. Int J Mol Sci 23(20):12162. (PMID: 36293015960320810.3390/ijms232012162)
Dai Y, Liu J (2021) Omega-3 long-chain polyunsaturated fatty acid and sleep: a systematic review and meta-analysis of randomized controlled trials and longitudinal studies. Nutr Rev 79(8):847–868. (PMID: 3338287910.1093/nutrit/nuaa103)
Patan MJ, Kennedy DO, Husberg C, Hustvedt SO, Calder PC, Middleton B, Jackson PA (2021) Differential effects of DHA-and EPA-rich oils on sleep in healthy young adults: a randomized controlled trial. Nutrients 13(1):248. (PMID: 33467135783045010.3390/nu13010248)
Dighiri IM, Alsubaie AM, Hakami FM, Hamithi DM, Alshekh MM, Khobrani FA, Tawhari M (2022) Effects of omega-3 polyunsaturated fatty acids on brain functions: a systematic review. Cureus 14(10):e30091.
Dyall SC (2015) Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci 7:52. (PMID: 25954194440491710.3389/fnagi.2015.00052)
GBD 2016 Causes of Death Collaborators (2017) Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England) 390(10100):1151–1210. (PMID: 10.1016/S0140-6736(17)32152-9)
GBD 2016 dalys and HALE Collaborators (2017) Global, regional, and national disability-adjusted life-years (dalys) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England) 390(10100):1260–1344. (PMID: 10.1016/S0140-6736(17)32130-X)
Lange KW (2020) Omega-3 fatty acids and mental health. J Glob Health 4(1):18–30. (PMID: 10.1016/j.glohj.2020.01.004)
Calder PC (2018) Very long-chain n-3 fatty acids and human health: fact, fiction and the future. Proc Nutr Soc 77(1):52–72. (PMID: 2903928010.1017/S0029665117003950)
Calder PC (2015) Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta Gen Subj 1851(4):469–484.
Chiang N, Serhan CN (2020) Specialized pro-resolving mediator network: an update on production and actions. Essays Biochem 64(3):443–462. (PMID: 32885825768274510.1042/EBC20200018)
Guisto NM, Salvador GA, Castagnet PI, Pasquare SJ, Ilincheta de Boschero MG (2002) Age-associated changes in central nervous system glycerolipid composition and metabolism. Neurochem Res 27(11):1513–1223. (PMID: 10.1023/A:1021604623208)
Reimers A, Ljung H (2019) The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders. Ther Adv Psychopharmacol 9:204512319858901. (PMID: 10.1177/2045125319858901)
Korotkova M, Jakobson PJ (2014) Persisting eicosanoid pathways in rheumatic diseases. Nat Rev Rheumatol 10(4):229–241. (PMID: 2451491510.1038/nrrheum.2014.1)
Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanza-Martinez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN, International Society for Nutritional Psychiatry Research (2015) Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2(3):271–274. (PMID: 2635990410.1016/S2215-0366(14)00051-0)
Chitre NM, Moniri NH, Murnane KS (2019) Omega-3 fatty acids as druggable therapeutics for neurodegenerative disorders. CNS Neurol Disord Drug Targets 18(10):735–749. (PMID: 31724519720489010.2174/1871527318666191114093749)
Healy-Stoffel M, Levant B (2018) N-3 (omega-3) fatty acids: effects on brain dopamine systems and potential role in the etiology and treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 17(3):216–232. (PMID: 29651972656391110.2174/1871527317666180412153612)
Lengqvist J, Mata De Urquiza A, Bergman AC, Willson TM, Sjovall J, Perlmann T, Griffiths WJ (2004) Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics 3(7):692–703.
Simpoulos AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 233(6):674–688. (PMID: 10.3181/0711-MR-311)
Biesalki HK, Erdman JW Jr, Hathcock J, Ellwood K, Beatty S, Johnson E, Marchioli R, Lauritzen L, Rice HB, Shao A, Griffiths JC (2013) Nutrient reference values for bioactives: new approaches needed? A conference report. Eur J Nutr 52(Suppl 1):1–9. (PMID: 10.1007/s00394-013-0503-0)
Harris WS (2018) The Omega-6:omega-3 ratio: a critical appraisal and possible successor. Prostaglandins Leukot Essent Fatty Acids Prostag Leukotr Ess 132:34–40. (PMID: 10.1016/j.plefa.2018.03.003)
Miura K, Hughes MCB, Ungerer JPJ, Smith DD, Green AC (2018) Absolute versus relative measures of plasma fatty acids and health outcomes: example of phospholipid omega-3 and omega-6 fatty acids and all-cause mortality in women. Eur J Nutr 57(2):713–722. (PMID: 2799531610.1007/s00394-016-1358-y)
Bazinet RP, Laye S (2014) Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 15(12):771–785. (PMID: 2538747310.1038/nrn3820)
Hachem M, Geloen A, Van AL, Foumaux B, Fenart L, Gosselet F, Da Silva P, Breton G, Lagarde M, Picq M, Bernoud-Hubac N (2016) Efficient docosahexaenoic acid uptake by the brain from a structured phospholipid. Mol Neurobiol 53(5):3205–3215. (PMID: 2604166110.1007/s12035-015-9228-9)
Reimers A, Ljung H (2019) The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders. Ther Adv Psychopharmacol 9:2045125319858901. (PMID: 31258889659166410.1177/2045125319858901)
Lopez-Toledano MA, Thorsteinsson T, Daak A, Maki KC, Johns C, Rabinowicz AL, Sancilio FD (2017) A novel ω-3 acid ethyl Ester formulation incorporating advanced lipid technologies™ (ALT ® ) improves docosahexaenoic acid and eicosapentaenoic acid bioavailability compared with Lovaza ® . Clin Ther 39(3):581–591. (PMID: 2818936410.1016/j.clinthera.2017.01.020)
Hinriksdottir HH, Jonsdottir VL, Sveinsdottir K, Martinsdottir E, Ramel A (2015) Bioavailability of long-chain n-3 fatty acids from enriched meals and from microencapsulated powder. Eur J Clin Nutr 69(3):344–348. (PMID: 2540696710.1038/ejcn.2014.250)
Crawford MA, Bloom M, Cunnane S, Holsmen H, Ghebremeskel K, Parkington J, Broadhurst CL (2001) Docosahexaenoic acid and cerebral evolution. World Rev Nutr Diet 88:6–17. (PMID: 1193597210.1159/000059743)
Gibbons A (2007) Paleoanthropology. Food for thought. N Y Sci J 316(5831):1558–1560. (PMID: 10.1126/science.316.5831.1558)
Whiteford HA, Ferrari AJ, Degenhardt L, Feigin V, Vos T (2015) The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010. PLoS One 10(2):e0116820. (PMID: 25658103432005710.1371/journal.pone.0116820)
Malhi GS, Mann JJ (2018) Depression. Lancet (London-England) 392(10161):2299–2312. (PMID: 3039651210.1016/S0140-6736(18)31948-2)
Muller CP, Reichel M, Muhle C, Rhein C, Gulbins E, Kornhuber J (2015) Brain membrane lipids in major depression and anxiety disorders. Biochim Biophys Acta Gen Subj 185(8):1052–1065.
Czysz AH, Rasenick MM (2013) G-protein signaling, lipid rafts and the possible sites of action for the antidepressant effects of n-3 polyunsaturated fatty acids. CNS Neurol Disord Drug Targets 12(4):466–473. (PMID: 23574156371434410.2174/1871527311312040005)
Su KP, Huang SY, Peng CY, Lai HC, Huang CL, Chen YC, Aitchison KJ, Pariante CM (2010) Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. Biol Psychiatry 67(6):550–557. (PMID: 2003461410.1016/j.biopsych.2009.11.005)
Owen MJ, Sawa A, Mortensen PB (2016) Schizophrenia. Lancet (London, England) 388(10039):86–97. (PMID: 2677791710.1016/S0140-6736(15)01121-6)
Alvarez-Jimenez M, Parker AG, Hetrick SE, McGorry PD, Gleeson JF (2011) Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis. Schizophr Bull 37(3):619–630. (PMID: 1990096210.1093/schbul/sbp129)
Horrobin DF (1998) The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr Res 30(3):193–208. (PMID: 958951410.1016/S0920-9964(97)00151-5)
Horrobin DF, Glen AI, Vaddadi K (1994) The membrane hypothesis of schizophrenia. Schizophr Res 13(3):195–207. (PMID: 784113210.1016/0920-9964(94)90043-4)
Pawelczyk T, Grancow-Grabka M, Trafalska E, Szemraj J, Pawelczyk A (2017) Oxidative stress reduction related to the efficacy of n-3 polyunsaturated fatty acids in first episode schizophrenia: secondary outcome analysis of the OFFER randomized trial. Prostaglandins Leukot 121:7–13. (PMID: 10.1016/j.plefa.2017.05.004)
Phillips ML, Kupfer DJ (2013) Bipolar disorder diagnosis: challenges and future directions. Lancet (London, England) 381(9878):1663–1671. (PMID: 2366395210.1016/S0140-6736(13)60989-7)
McNamara RK, Welge JA (2016) Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disord 18(3):300–306. (PMID: 27087497488223810.1111/bdi.12386)
Clayton EH, Hanstock TL, Hirneth SJ, Kable CJ, Garg ML, Hazell PL (2009) Reduced mania and depression in juvenile bipolar disorder associated with long-chain ω-3 polyunsaturated fatty acid supplementation. Eur J Clin Nutr 63(8):1037–1040. (PMID: 1915615810.1038/ejcn.2008.81)
Montgomery P, Richardson AJ (2008) Omega-3 fatty acids for bipolar disorder. Cochrane Database Syst Rev 2.
Pamplona R, Dalfo E, Ayala V, Bellmunt MJ, Prat J, Ferrer I, Portero-Otin M (2005) Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation: effects of Alzheimer disease and identification of lipoxidation targets. J Biol Chem 280(22):21522–21530. (PMID: 1579996210.1074/jbc.M502255200)
Whitfield JF (2006) Can statins put the brakes on Alzheimer’s disease? Expert Opin Investig Drugs 15(12):1479–1485. (PMID: 1710727410.1517/13543784.15.12.1479)
Wang L, Fan H, He J, Wang L, Tian Z, Wang C (2018) Protective effects of omega-3 fatty acids against Alzheimer’s disease in rat brain endothelial cells. Brain Behav 8(11):e01037. (PMID: 30298620623623610.1002/brb3.1037)
Calon F, Cole G (2007) Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodege. Prostaglandins Leukot 77(5–6):287–293. (PMID: 10.1016/j.plefa.2007.10.019)
Olivera-Perez HM, Lam L, Dang J, Jiang W, Rodriguez F, Rigali E, Fiala M (2017) Omega-3 fatty acids increase the unfolded protein response and improve amyloid-β phagocytosis by macrophages of patients with mild cognitive impairment. FASEB J 31(10):4359. (PMID: 28634213560289410.1096/fj.201700290R)
Tarasova TV, Lytkina OA, Roman AY, Bachurin SO, Ustyugov AA (2016) The role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area. Dokl Biol Sci 466:5–7. (PMID: 2702136010.1134/S0012496616010117)
Barros AS, Crispim RYG, Cavalcanti JU, Souza RB, Lemos JC, Filho C, Aguiar LMV (2017) Impact of the chronic omega-3 fatty acids supplementation in Hemiparkinsonism model induced by 6-hydroxydopamine in rats. Basic Clin Pharmacol Toxicol 120(6):523–531. (PMID: 2788327410.1111/bcpt.12713)
Serhan CN, Chiang N, Van Dyke TE (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8(5):349–361. (PMID: 18437155274459310.1038/nri2294)
Nakamoto K (2017) A new pain regulatory system via the brain long chain fatty acid receptor GPR40/FFA1 signal. Yakugaku Zasshi 137(2):199–204. (PMID: 2815433210.1248/yakushi.16-00208)
Ichimura A, Hirasawa A, Hara T, Tsujimoto G (2009) Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat 89(3–4):82–88. (PMID: 1946045410.1016/j.prostaglandins.2009.05.003)
Cheshmehkani A, Senatorov IS, Kandi P, Singh M, Britt A, Hayslett R, Moniri NH (2015) Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon. J Inflamm Res 64(10):809–815. (PMID: 10.1007/s00011-015-0864-3)
Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F (2014) Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One 9(5):e96905. (PMID: 24805797401312110.1371/journal.pone.0096905)
Ovcharova EM, Danovska MP, Marinova DL, Pendicheva DI, Tonchev PT, Shepherd NM (2022) Role of diet and supplementation with omega-3 polyunsaturated fatty acids for managing chronic fatigue in patients with relapsing-remitting multiple sclerosis. Biomed Res J 15(2):99–104.
AlAmmar WA, Albeesh FH, Ibrahim LM, Algindan YY, Yamani LZ, Khattab RY (2021) Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic review. Nutr Neurosci 24(7):569–579. (PMID: 3146218210.1080/1028415X.2019.1659560)
Langer-Gould A, Black LJ, Waubant E, Smith JB, Wu J, Gonzales EG, Shao X, Koebnick C, Lucas RM, Xiang A, Barcellos LF (2020) Seafood, fatty acid biosynthesis genes, and multiple sclerosis susceptibility. Mult Scler 26(12):1476–1485. (PMID: 3306362110.1177/1352458519872652)
Li X, Bi X, Wang S, Zhang Z, Li F, Zhao AZ (2019) Therapeutic potential of ω-3 polyunsaturated fatty acids in human autoimmune diseases. Front Immunol 10:2241.
Mostafa GA, Al-Ayadhi LY (2015) Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations. Behav Brain Funct 11:4. (PMID: 25757041433272510.1186/s12993-014-0048-2)
Bell JG, Miller D, MacDonald DJ, MacKinlay EE, Dick JR, Cheseldine S, O'Hare AE (2010) The fatty acid compositions of erythrocyte and plasma polar lipids in children with autism, developmental delay or typically developing controls and the effect of fish oil intake. Br J Nutr 103(8):1160–1167. (PMID: 1999547010.1017/S0007114509992881)
Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW (2006) Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Other Lipid Mediat 74(4):215–221.
Mazahery H, Stonehouse W, Delshad M, Kruger MC, Conlon CA, Beck KL, Von Hurst PR (2017) Relationship between long chain n-3 polyunsaturated fatty acids and autism spectrum disorder: systematic review and meta-analysis of case-control and randomised controlled trials. Nutrients 9(2):155. (PMID: 28218722533158610.3390/nu9020155)
Akbar U, Yang M, Kurian D, Mohan C (2017) Omega-3 fatty acids in rheumatic diseases: a critical review. J Clin Rheumatol 23(6):330–339. (PMID: 2881672210.1097/RHU.0000000000000563)
Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M, Ng CH (2018) Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Focus (Am Psychiatr Publ) 16(3):328–340. (PMID: 32015713)
Bai ZG, Bo A, Wu SJ, Gai QY, Chi I (2018) Omega-3 polyunsaturated fatty acids and reduction of depressive symptoms in older adults: a systematic review and meta-analysis. J Affect Disord 241:241–248. (PMID: 3013880810.1016/j.jad.2018.07.057)
Bae JH, Kim G (2018) Systematic review and meta-analysis of omega-3-fatty acids in elderly patients with depression. Nutr Res 50:1–9. (PMID: 2954026710.1016/j.nutres.2017.10.013)
Hsu MC, Tung CY, Chen HE (2018) Omega-3 polyunsaturated fatty acid supplementation in prevention and treatment of maternal depression: putative mechanism and recommendation. J Affect Disord 238:47–61. (PMID: 2986018310.1016/j.jad.2018.05.018)
Glen AI, Glen EM, Horrobin DF, Vaddadi KS, Spellman M, Morse-Fisher N, Ellis K, Skinner FS (1994) A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases. Schizophr Res 12(1):53–61. (PMID: 801858510.1016/0920-9964(94)90084-1)
Amminger GP, Schafer MR, Klier CM, Slavik JM, Holzer I, Holub M, Goldstone S, Whitford TJ, McGorry PD, Berk M (2012) Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals. Mol Psychiatry 17(12):1150–1152. (PMID: 2218293710.1038/mp.2011.167)
Schlögelhofer M, Amminger GP, Schaefer MR, Fusar-Poli P, Smesny S, McGorry P, Berger G, Mossaheb N (2014) Polyunsaturated fatty acids in emerging psychosis: a safer alternative? Early Interv Psychiatry 8(3):199–208. (PMID: 2486100410.1111/eip.12151)
Amminger GP, Schafer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE (2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67(2):146–154. (PMID: 2012411410.1001/archgenpsychiatry.2009.192)
Emsley R, Niehaus DJ, Koen L, Oosthuizen PP, Turner HJ, Carey P, van Rensburg SJ, Maritz JS, Murck H (2006) The effects of eicosapentaenoic acid in tardive dyskinesia: a randomized, placebo-controlled trial. Schizophr Res 84(1):112–120. (PMID: 1663232910.1016/j.schres.2006.03.023)
Chiu CC, Huang SY, Su KP, Lu ML, Huang MC, Chen CC, Shen WW (2003) Polyunsaturated fatty acid deficit in patients with bipolar mania. Eur Neuropsychopharmacol 13(2):99–103. (PMID: 1265095310.1016/S0924-977X(02)00130-X)
Evans SJ, Ringrose RN, Harrington GJ, Mancuso P, Burant CF, McInnis MG (2014) Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. J Psychiatr Res 57:58–64. (PMID: 2495386010.1016/j.jpsychires.2014.06.001)
Fristad MA, Young AS, Vesco AT, Nader ES, Healy KZ, Gardner W, Wolfson HL, Arnold LE (2015) A randomized controlled trial of individual family psychoeducational psychotherapy and omega-3 fatty acids in youth with subsyndromal bipolar disorder. J Child Adolesc Psychopharmacol 25(10):764–774. (PMID: 26682997469165410.1089/cap.2015.0132)
Sarris J, Mischoulon D, Schweitzer I (2012) Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression. J Clin Psychiatry 73(1):81–86. (PMID: 2190302510.4088/JCP.10r06710)
Olloquequi J, Ettcheto M, Cano A, Sanchez-López E, Carrasco M, Espinosa T, Beas-Zarate C, Gudino-Cabrera G, Urena-Guerrero ME, Verdaguer E, Folch J, Auladell C, Camins A (2022) Impact of new drugs for therapeutic intervention in Alzheimer’s disease. Front Biosci 27(5):146. (PMID: 10.31083/j.fbl2705146)
Faxen-Irving G, Freund-Levi Y, Eriksdotter-Jonhagen M, Basun H, Hjorth E, Palmblad J, Vedin I, Cederholm T, Wahlund LO (2013) Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n-3 fatty acid supplementation in patients with Alzheimer’s disease: the OmegAD study. J Alzheimers Dis 36(1):1–6. (PMID: 2356324510.3233/JAD-121828)
Tamtaji OR, Taghizadeh M, Aghadavod E, Mafi A, Dadgostar E, Daneshvar Kakhak R, Abolhassani J, Asemi Z (2019) The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson’s disease: a randomized, double-blind, placebo-controlled trial. Clin Neurol Neurosurg 176:116–121. (PMID: 3055409210.1016/j.clineuro.2018.12.006)
Pantzaris MC, Loukaides GN, Ntzani EE, Patrikios IS (2013) A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids with vitamins (PLP10) in relapsing remitting multiple sclerosis: a randomised, double-blind, placebo-controlled proof-of-concept clinical trial. BMJ Open 3(4):e002170. (PMID: 23599375364149510.1136/bmjopen-2012-002170)
Bent S, Bertoglio K, Hendren RL (2009) Omega-3 fatty acids for autistic spectrum disorder: a systematic review. Rev J Autism Dev Disord 39(8):1145–1154. (PMID: 10.1007/s10803-009-0724-5)
James S, Montgomery P, Williams K (2011) Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). Cochrane Database Syst Rev 11:CD007992.
Mazahery H, Stonehouse W, Delshad M, Kruger MC, Conlon CA, Beck KL, Von Hurst PR (2017) Relationship between long chain n-3 polyunsaturated fatty acids and autism spectrum disorder: systematic review and meta-analysis of case-control and randomised controlled trials. Nutr J 9(2):155.
Noroozieseyedhosseini H, Imani R, Sumra B, Tariq M (2023) The effects of omega-3 and omega-6 fatty acids on the mental and physical health of children, adolescents, and adults.
فهرسة مساهمة: Keywords: ALA; DHA; Diseases; EPA; Health; Neurochemical disorders; Neurodegenerative disorders; Physiology
المشرفين على المادة: 0 (Fatty Acids, Omega-3)
AAN7QOV9EA (Eicosapentaenoic Acid)
25167-62-8 (Docosahexaenoic Acids)
0 (Fatty Acids, Unsaturated)
0 (Fatty Acids)
تواريخ الأحداث: Date Created: 20240301 Date Completed: 20240304 Latest Revision: 20240304
رمز التحديث: 20240304
DOI: 10.1007/978-1-0716-3662-6_15
PMID: 38427239
قاعدة البيانات: MEDLINE
الوصف
تدمد:1940-6029
DOI:10.1007/978-1-0716-3662-6_15