دورية أكاديمية
أعرض في EDS

Effects of preterm birth, maternal ART and breastfeeding on 24-month infant HIV-free survival in a randomized trial.

التفاصيل البيبلوغرافية
العنوان: Effects of preterm birth, maternal ART and breastfeeding on 24-month infant HIV-free survival in a randomized trial.
المؤلفون: Dadabhai S; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health.; Kamuzu University of Health Sciences-Johns Hopkins Research Project, Blantyre, Malawi., Chou VB; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD., Pinilla M; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA., Chinula L; Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; University of North Carolina Project Malawi, Tidziwe Centre, Lilongwe, Malawi., Owor M; MU-JHU Research Collaboration; Upper Mulago Hill Road, Kampala, Uganda., Violari A; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Soweto., Moodley D; Centre for the AIDS Programme of Research in South Africa and School of Clinical Medicine, University of KwaZulu Natal, Congella, South Africa., Stranix-Chibanda L; Child, Adolescent and Women's Health Department, Faculty of Medicine and Health Sciences, University of Zimbabwe, Avondale.; University of Zimbabwe Clinical Trials Research Centre, Belgravia, Harare, Zimbabwe., Matubu TA; Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Chareka GT; B.J. Government Medical College, Department of Paediatrics, Pune, India., Theron G; Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Kinikar AA; B.J. Government Medical College, Department of Paediatrics, Pune, India., Mubiana-Mbewe M; Centre for Infectious Disease Research in Zambia, George CRS, Lusaka, Zambia., Fairlie L; Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg., Bobat R; Department of Paediatrics and Child Health, University of KwaZulu-Natal, Durban, South Africa., Mmbaga BT; Kilimanjaro Christian Medical Centre, Kilimanjaro Clinical Research Institute and Kilimanjaro Christian Medical University College/Kilimanjaro CRS, Moshi, Tanzania., Flynn PM; St. Jude Children's Research Hospital, Memphis, TN., Taha TE; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health., McCarthy KS; FHI 360, Durham, NC., Browning R; National Institute of Allergy and Infectious Diseases/NIH, Rockville, MD., Mofenson LM; Elizabeth Glaser Pediatric AIDS Foundation, Washington DC, USA., Brummel SS; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA., Fowler MG; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
مؤلفون مشاركون: IMPAACT PROMISE 1077BF/FF team
المصدر: AIDS (London, England) [AIDS] 2024 Jul 15; Vol. 38 (9), pp. 1304-1313. Date of Electronic Publication: 2024 Mar 01.
نوع المنشور: Journal Article; Randomized Controlled Trial; Multicenter Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : London, England : Lippincott Williams & Wilkins
Original Publication: London : Gower Academic Journals, c1987-
مواضيع طبية MeSH: Breast Feeding* , HIV Infections*/drug therapy , HIV Infections*/mortality , Premature Birth*/epidemiology, Humans ; Female ; Pregnancy ; Infant, Newborn ; Infant ; Adult ; India/epidemiology ; Infectious Disease Transmission, Vertical/prevention & control ; Pregnancy Complications, Infectious/drug therapy ; Male ; Africa/epidemiology ; Anti-HIV Agents/therapeutic use ; Young Adult
مستخلص: Background: IMPAACT 1077BF/FF (PROMISE) compared the safety/efficacy of two HIV antiretroviral therapy (ART) regimens to zidovudine (ZDV) alone during pregnancy for HIV prevention. PROMISE found an increased risk of preterm delivery (<37 weeks) with antepartum triple ART (TDF/FTC/LPV+r or ZDV/3TC/LPV+r) compared with ZDV alone. We assessed the impact of preterm birth, breastfeeding, and antepartum ART regimen on 24-month infant survival.
Methods: We compared HIV-free and overall survival at 24 months for liveborn infants by gestational age, time-varying breastfeeding status, and antepartum ART arm at 14 sites in Africa and India. Kaplan-Meier survival probabilities and Cox proportional hazards ratios were estimated.
Results: Three thousand four hundred and eighty-two live-born infants [568 (16.3%) preterm and 2914 (83.7%) term] were included. Preterm birth was significantly associated with lower HIV-free survival [0.85; 95% confidence interval (CI) 0.82-0.88] and lower overall survival (0.89; 95% CI 0.86-0.91) versus term birth (0.96; 95% CI 0.95-0.96). Very preterm birth (<34 weeks) was associated with low HIV-free survival (0.65; 95% CI 0.54-0.73) and low overall survival (0.66; 95% CI 0.56-0.74). Risk of HIV infection or death at 24 months was higher with TDF-ART than ZDV-ART (adjusted hazard ratio 2.37; 95% CI 1.21-4.64). Breastfeeding initiated near birth decreased risk of infection or death at 24 months (adjusted hazard ratio 0.05; 95% CI 0.03-0.08) compared with not breastfeeding.
Conclusion: Preterm birth and antepartum TDF-ART were associated with lower 24-month HIV-free survival compared with term birth and ZDV-ART. Any breastfeeding strongly promoted HIV-free survival, especially if initiated close to birth. Reducing preterm birth and promoting infant feeding with breastmilk among HIV/antiretroviral drug-exposed infants remain global health priorities.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
التعليقات: Comment in: AIDS. 2024 Jul 15;38(9):1430-1431. doi: 10.1097/QAD.0000000000003911. (PMID: 38932745)
References: N Engl J Med. 2015 Aug 27;373(9):795-807. (PMID: 26192873)
HIV Med. 2014 Apr;15(4):233-8. (PMID: 24025074)
AIDS. 2013 Jul 31;27(12):1911-20. (PMID: 24180000)
Lancet. 2021 Apr 3;397(10281):1276-1292. (PMID: 33812487)
Clin Pharmacokinet. 2020 Oct;59(10):1185-1194. (PMID: 32757103)
J Infect Dis. 2006 May 1;193(9):1195-201. (PMID: 16586354)
N Engl J Med. 2016 Nov 3;375(18):1726-1737. (PMID: 27806243)
J Acquir Immune Defic Syndr. 2018 Sep 1;79(1):1-9. (PMID: 29847475)
J Acquir Immune Defic Syndr. 2019 Jan 1;80(1):94-102. (PMID: 30272633)
J Pediatr. 1991 Sep;119(3):417-23. (PMID: 1880657)
Pediatr Infect Dis J. 2021 Mar 1;40(3):245-250. (PMID: 33480662)
Lancet Glob Health. 2018 Jul;6(7):e804-e810. (PMID: 29880310)
AIDS. 2019 Dec 1;33(15):2403-2413. (PMID: 31764105)
J Infect Dis. 2012 Dec 1;206(11):1695-705. (PMID: 23066160)
Int J Gynaecol Obstet. 2020 Jul;150(1):31-33. (PMID: 32524596)
Lancet Glob Health. 2019 Jan;7(1):e37-e46. (PMID: 30389451)
AIDS. 2020 Sep 1;34(11):1643-1656. (PMID: 32701581)
J Acquir Immune Defic Syndr. 2018 Apr 1;77(4):383-392. (PMID: 29239901)
Br J Obstet Gynaecol. 1998 Aug;105(8):836-48. (PMID: 9746375)
Lancet. 2013 Aug 3;382(9890):417-425. (PMID: 23746775)
J Perinatol. 2020 Jun;40(6):833-843. (PMID: 31767981)
Expert Rev Anti Infect Ther. 2014 Mar;12(3):293-306. (PMID: 24502750)
N Engl J Med. 2000 Aug 10;343(6):378-84. (PMID: 10933736)
J Infect Dis. 2011 Aug 15;204(4):506-14. (PMID: 21791651)
BJOG. 2010 Oct;117(11):1399-410. (PMID: 20716250)
معلومات مُعتمدة: UM1 AI068616 United States AI NIAID NIH HHS; UM1 AI068632 United States AI NIAID NIH HHS; UM1 AI069518 United States AI NIAID NIH HHS; UM1 AI069530 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Anti-HIV Agents)
تواريخ الأحداث: Date Created: 20240301 Date Completed: 20240627 Latest Revision: 20240708
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC11211053
DOI: 10.1097/QAD.0000000000003878
PMID: 38427596
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5571
DOI:10.1097/QAD.0000000000003878