دورية أكاديمية
أعرض في EDS

The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin.

التفاصيل البيبلوغرافية
العنوان: The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin.
المؤلفون: Greenhalgh R; School of Biological Sciences, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA. Electronic address: robert.greenhalgh@utah.edu., Klure DM; School of Biological Sciences, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA. Electronic address: dylan.klure@utah.edu., Orr TJ; School of Biological Sciences, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA. Electronic address: teriorr@nmsu.edu., Armstrong NM; School of Biological Sciences, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA. Electronic address: u1220939@utah.edu., Shapiro MD; School of Biological Sciences, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA. Electronic address: mike.shapiro@utah.edu., Dearing MD; School of Biological Sciences, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA. Electronic address: denise.dearing@utah.edu.
المصدر: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2024 Jun; Vol. 280, pp. 109870. Date of Electronic Publication: 2024 Feb 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 100959500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0456 (Print) Linking ISSN: 15320456 NLM ISO Abbreviation: Comp Biochem Physiol C Toxicol Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier Science, c2000-
مواضيع طبية MeSH: Larrea*/metabolism, Humans ; Animals ; Creosote/toxicity ; Creosote/metabolism ; Herbivory/genetics ; Biotransformation ; Rodentia/metabolism ; Sigmodontinae/genetics ; Sigmodontinae/metabolism
مستخلص: Liver biotransformation enzymes have long been thought to enable animals to feed on diets rich in xenobiotic compounds. However, despite decades of pharmacological research in humans and rodents, little is known about hepatic gene expression in specialized mammalian herbivores feeding on toxic diets. Leveraging a recently identified population of the desert woodrat (Neotoma lepida) found to be highly tolerant to toxic creosote bush (Larrea tridentata), we explored the expression changes of suites of biotransformation genes in response to diets enriched with varying amounts of creosote resin. Analysis of hepatic RNA-seq data indicated a dose-dependent response to these compounds, including the upregulation of several genes encoding transcription factors and numerous phase I, II, and III biotransformation families. Notably, elevated expression of five biotransformation families - carboxylesterases, cytochromes P450, aldo-keto reductases, epoxide hydrolases, and UDP-glucuronosyltransferases - corresponded to species-specific duplication events in the genome, suggesting that these genes play a prominent role in N. lepida's adaptation to creosote bush. Building on pharmaceutical studies in model rodents, we propose a hypothesis for how the differentially expressed genes are involved in the biotransformation of creosote xenobiotics. Our results provide some of the first details about how these processes likely operate in the liver of a specialized mammalian herbivore.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R35 GM131787 United States GM NIGMS NIH HHS; T32 GM141848 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Biotransformation; Creosote bush; Differential expression; Transcriptomics; Woodrats
المشرفين على المادة: 8021-39-4 (Creosote)
تواريخ الأحداث: Date Created: 20240301 Date Completed: 20240412 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11006593
DOI: 10.1016/j.cbpc.2024.109870
PMID: 38428625
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-0456
DOI:10.1016/j.cbpc.2024.109870