دورية أكاديمية
أعرض في EDS

Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease.

التفاصيل البيبلوغرافية
العنوان: Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease.
المؤلفون: Wijnands AM; Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands., Penning de Vries BBL; Department of Epidemiology and Health Economics, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Lutgens MWMD; Department of Gastroenterology and Hepatology, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands., Bakhshi Z; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Al Bakir I; Department of Gastroenterology, Chelsea and Westminster Hospital, London, United Kingdom., Beaugerie L; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Assistance Publique-Hôpitaux de Paris, Department of Gastroenterology, Hôpital Saint-Antoine, Paris, France., Bernstein CN; University of Manitoba IBD Clinical and Research Center, Winnipeg, Manitoba, Canada; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Chang-Ho Choi R; Department of Gastroenterology and Hepatology, Concord Repatriation General Hospital, Sydney, New South Wales, Australia., Coelho-Prabhu N; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Graham TA; Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Genomics and Evolutionary Dynamics Laboratory, Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom., Hart AL; Inflammatory Bowel Disease Unit, St Mark's Hospital, London, United Kingdom., Ten Hove JR; Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands., Itzkowitz SH; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York., Kirchgesner J; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Assistance Publique-Hôpitaux de Paris, Department of Gastroenterology, Hôpital Saint-Antoine, Paris, France., Mooiweer E; Department of Gastroenterology and Hepatology, Hospital St Jansdal, Harderwijk, The Netherlands., Shaffer SR; University of Manitoba IBD Clinical and Research Center, Winnipeg, Manitoba, Canada; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Shah SC; Division of Gastroenterology, University of California, San Diego, La Jolla, California; Gastroenterology Section, Veterans Affairs San Diego Healthcare System, La Jolla, California., Elias SG; Department of Epidemiology and Health Economics, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Oldenburg B; Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: boldenbu@umcutrecht.nl.
مؤلفون مشاركون: Dutch Initiative on Crohn and Colitis (ICC)
المصدر: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2024 Aug; Vol. 22 (8), pp. 1697-1708. Date of Electronic Publication: 2024 Feb 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders for the American Gastroenterological Association, 2003-
مواضيع طبية MeSH: Colorectal Neoplasms*/epidemiology , Colorectal Neoplasms*/diagnosis , Colorectal Neoplasms*/pathology , Inflammatory Bowel Diseases*/complications , Colonoscopy*, Humans ; Male ; Female ; Middle Aged ; Adult ; Risk Assessment/methods ; Aged ; Cohort Studies ; Canada/epidemiology
مستخلص: Background & Aims: Colonoscopic surveillance is recommended in patients with colonic inflammatory bowel disease (IBD) given their increased risk of colorectal cancer (CRC). We aimed to develop and validate a dynamic prediction model for the occurrence of advanced colorectal neoplasia (aCRN, including high-grade dysplasia and CRC) in IBD.
Methods: We pooled data from 6 existing cohort studies from Canada, The Netherlands, the United Kingdom, and the United States. Patients with IBD and an indication for CRC surveillance were included if they underwent at least 1 follow-up procedure. Exclusion criteria included prior aCRN, prior colectomy, or an unclear indication for surveillance. Predictor variables were selected based on the literature. A dynamic prediction model was developed using a landmarking approach based on Cox proportional hazard modeling. Model performance was assessed with Harrell's concordance-statistic (discrimination) and by calibration curves. Generalizability across surveillance cohorts was evaluated by internal-external cross-validation.
Results: The surveillance cohorts comprised 3731 patients, enrolled and followed-up in the time period from 1973 to 2021, with a median follow-up period of 5.7 years (26,336 patient-years of follow-up evaluation); 146 individuals were diagnosed with aCRN. The model contained 8 predictors, with a cross-validation median concordance statistic of 0.74 and 0.75 for a 5- and 10-year prediction window, respectively. Calibration plots showed good calibration. Internal-external cross-validation results showed medium discrimination and reasonable to good calibration.
Conclusions: The new prediction model showed good discrimination and calibration, however, generalizability results varied. Future research should focus on formal external validation and relate predicted aCRN risks to surveillance intervals before clinical application.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Investigator: AA van Bodegraven; HH Fidder; MMC Hirdes; F Hoentjen; JM Jansen; N Mahmmod; AE van der Meulen-de Jong; CY Ponsioen; FDM van Schaik; CJ van der Woude
Keywords: Crohn’s Disease; Prognosis; Screening; Ulcerative Colitis
تواريخ الأحداث: Date Created: 20240302 Date Completed: 20240725 Latest Revision: 20240725
رمز التحديث: 20240726
DOI: 10.1016/j.cgh.2024.02.014
PMID: 38431223
قاعدة البيانات: MEDLINE
الوصف
تدمد:1542-7714
DOI:10.1016/j.cgh.2024.02.014