دورية أكاديمية
Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk.
العنوان: | Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk. |
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المؤلفون: | Ivanova AA; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Gardner MS; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Kusovschi JD; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Parks BA; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Schieltz DM; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Bareja A; Duke Molecular Physiology Institute, Duke University School of Medicine, Duke University, Durham, NC, United States., McGarrah RW 3rd; Duke Molecular Physiology Institute, Duke University School of Medicine, Duke University, Durham, NC, United States., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Duke University, Durham, NC, United States., Kuklenyik Z; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Pirkle JL; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States., Barr JR; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States. |
المصدر: | Clinical chemistry [Clin Chem] 2024 Mar 02; Vol. 70 (3), pp. 528-537. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9421549 Publication Model: Print Cited Medium: Internet ISSN: 1530-8561 (Electronic) Linking ISSN: 00099147 NLM ISO Abbreviation: Clin Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: Baltimore, Md. : P.B. Hoeber, [c1955- |
مواضيع طبية MeSH: | Coronary Artery Disease*/diagnosis , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use, Humans ; Coronary Angiography/methods ; Lipids ; Risk Assessment ; Risk Factors ; Middle Aged ; Aged |
مستخلص: | Background: Lipid profiling is central for coronary artery disease (CAD) risk assessment. Nonadherence or unreported use of lipid-lowering drugs, particularly statins, can significantly complicate the association between lipid profile measures and CAD clinical outcomes. By combining medication history evaluation with statin analysis in plasma, we determined the effects of inaccurately reported statin use on lipid profile measures and their association with CAD risk. Methods: We compared medication history of statin use with statin concentration measurements, by liquid chromatography-tandem mass spectrometry, in 690 participants undergoing coronary angiography (63 ± 11 years of age). Nominal logistic regression was employed to model CAD diagnosis with statin measurements, phenotypic, and lipid profile characteristics. Results: Medication history of statin use was confirmed by statin assay for 81% of the patients. Surprisingly, statins were detected in 46% of patients without statin use records. Nonreported statin use was disproportionately higher among older participants. Stratifying samples by statin history resulted in underestimated LDL-lipid measures. Apolipoprotein B concentrations had a significant inverse CAD association, which became nonsignificant upon re-stratification using the statin assay data. Conclusions: Our study uncovered prominent discrepancies between medication records and actual statin use measured by mass spectrometry. We showed that inaccurate statin use assessments may lead to overestimation and underestimation of LDL levels in statin user and nonuser categories, exaggerating the reverse epidemiology association between LDL levels and CAD diagnosis. Combining medication history and quantitative statin assay data can significantly improve the design, analysis, and interpretation of clinical and epidemiological studies. (© Association for Diagnostics & Laboratory Medicine 2024.) |
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معلومات مُعتمدة: | CC999999 United States ImCDC Intramural CDC HHS |
المشرفين على المادة: | 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 0 (Lipids) |
تواريخ الأحداث: | Date Created: 20240302 Date Completed: 20240305 Latest Revision: 20240818 |
رمز التحديث: | 20240818 |
مُعرف محوري في PubMed: | PMC11329871 |
DOI: | 10.1093/clinchem/hvad223 |
PMID: | 38431279 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1530-8561 |
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DOI: | 10.1093/clinchem/hvad223 |