دورية أكاديمية
أعرض في EDS

Alteration of SERPINH1 is associated with elevated expression in head and neck squamous cell carcinomas and its clinicopathological significance.

التفاصيل البيبلوغرافية
العنوان: Alteration of SERPINH1 is associated with elevated expression in head and neck squamous cell carcinomas and its clinicopathological significance.
المؤلفون: Murugesan D; Department of Microbiology, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Poonamalle High Road, Chennai, Tamil Nadu 600077, India., Kannan B; Molecular Biology Lab, Centre for Cellular and Molecular Research, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India., As SG; Department of Microbiology, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Poonamalle High Road, Chennai, Tamil Nadu 600077, India., Jayaseelan VP; Clinical Genetics Lab, Centre for Cellular and Molecular Research, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India., Arumugam P; Molecular Biology Lab, Centre for Cellular and Molecular Research, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India. Electronic address: paramasivama.sdc@saveetha.com.
المصدر: Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2024 Jun; Vol. 125 (3S), pp. 101811. Date of Electronic Publication: 2024 Mar 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101701089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7855 (Electronic) Linking ISSN: 24687855 NLM ISO Abbreviation: J Stomatol Oral Maxillofac Surg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Issy les Moulineaux Cedex : Elsevier Masson SAS, [2017]-
مواضيع طبية MeSH: Squamous Cell Carcinoma of Head and Neck*/pathology , Squamous Cell Carcinoma of Head and Neck*/diagnosis , Squamous Cell Carcinoma of Head and Neck*/metabolism , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/analysis , Biomarkers, Tumor*/genetics , Head and Neck Neoplasms*/pathology , Head and Neck Neoplasms*/metabolism , Head and Neck Neoplasms*/diagnosis , HSP47 Heat-Shock Proteins*/metabolism , HSP47 Heat-Shock Proteins*/genetics, Humans ; Male ; Female ; Prognosis ; Middle Aged ; Up-Regulation ; Gene Expression Regulation, Neoplastic ; Immunohistochemistry ; Aged ; Neoplasm Staging
مستخلص: Background/purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer-related death worldwide and contributes significantly to the burden of disease in South Asia, partially due to the lack of effective screening strategies. Identifying essential biomarkers is crucial for improved prognosis and treatment. This study investigates the potential of SERPINH1 as a prognostic marker in HNSCC, highlighting its significance amidst the molecular complexity.
Methods: The Cancer Genome Atlas HNSCC cohort, comprised of 520 tumors and 44 normal tissues, was analyzed using cBioportal, UALCAN, and Protein atlas tools. Expression patterns, survival outcomes, and clinical correlations of SERPINH1 were evaluated. In-depth analyses involved oral squamous cell carcinoma (OSCC) patient samples, protein expression, and functional exploration using various in-silico tools.
Results: SERPINH1 exhibited significant alteration and upregulation in HNSCC and OSCC, indicating its pan-cancer potential. Immunohistochemistry confirmed its overexpression in primary HNSCC tumors. Association analyses linked altered SERPINH1 levels with tumor stage, grade, metastasis, human papillomavirus (HPV) status, and patient prognosis. Functional analyses unveiled SERPINH1's involvement in critical cellular pathways and interactions with various proteins.
Conclusion: The significant alteration of SERPINH1 associated with upregulated expression in HNSCC and OSCC positions it as a promising diagnostic and prognostic marker. Further investigations are warranted to elucidate the underlying molecular mechanisms, paving the way for targeted therapeutic interventions and continued exploration of various malignancies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Masson SAS. All rights reserved.)
فهرسة مساهمة: Keywords: Biomarker; Genetics; Head and neck squamous cell carcinomas; Prognosis; SERPINH1; TCGA
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (SERPINH1 protein, human)
0 (HSP47 Heat-Shock Proteins)
تواريخ الأحداث: Date Created: 20240303 Date Completed: 20240526 Latest Revision: 20240530
رمز التحديث: 20240530
DOI: 10.1016/j.jormas.2024.101811
PMID: 38432483
قاعدة البيانات: MEDLINE
الوصف
تدمد:2468-7855
DOI:10.1016/j.jormas.2024.101811