دورية أكاديمية
Choline chloride/urea as a green and efficient deep eutectic solvent in three-component and four-component synthesis of novel pyrazole and pyrano[2,3-c] pyrazole derivatives with antibacterial and antifungal activity.
| العنوان: | Choline chloride/urea as a green and efficient deep eutectic solvent in three-component and four-component synthesis of novel pyrazole and pyrano[2,3-c] pyrazole derivatives with antibacterial and antifungal activity. |
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| المؤلفون: | Habeeb Naser I; Medical Laboratories Techniques Department, Al-Mustaqbal University, Hillah, Iraq., Thoulfikar A Alamir H; Faculty of Pharmacy, Department of Pharmaceutics, University of Al-Ameed, Karbala, Iraq., Al-Shukarji AH; Department of Medical Laboratories Technology, Al-Manara College for Medical Sciences, Maysan, Iraq., Ahmed BA; Department of Medical Engineering, Al-Nisour University College, Baghdad, Iraq., Qassem TA; Department of Medical Laboratory Technics, Al-Noor University College, Nineveh, Iraq., Kamal M; Department of Dentistry, Al-Hadi University College, Baghdad, Iraq., Almeleebia TM; Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Alwaily ER; Microbiology Research Group, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq., Hasan Kadhum E; National University of Science and Technology, Dhi Qar, Iraq., Alawadi A; College of Technical Engineering, The Islamic University, Najaf, Iraq.; College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq., Alsalamy A; College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq. |
| المصدر: | Frontiers in chemistry [Front Chem] 2024 Feb 16; Vol. 12, pp. 1342784. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | In this study, choline chloride/urea was used as a green deep eutectic solvent in the three-component reaction of hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrazole derivatives, and in the four-component reaction of methyl/ethyl acetoacetate, hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrano[2,3-c]pyrazole derivatives. Elemental analysis, 1 H, and 13 C NMR spectroscopy were used to confirm the structure of the synthesized pyrazole and pyrano[2,3-c] pyrazole derivatives. The antimicrobial effects of the synthesized pyrazole and pyrano[2,3-c] pyrazole derivatives were investigated. In antimicrobial tests, instructions from clinical and laboratory standards institutes were used. Antimicrobial study was done on pathogenic gram-positive and gram-negative species, and specialized aquatic strains and fungal species. Using choline chloride/urea, novel pyrazole derivatives and pyrano[2,3-c]pyrazole derivatives were synthesized, and other derivatives were synthesized with higher efficiency in less time than some previously reported methods. MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) obtained for derivatives were higher than some antibiotic drugs. Synthesis and reports of new derivatives of pyrazole and pyrano[2,3-c]pyrazole, and investigation and reports of their antimicrobial properties on gram-positive, gram-negative, and specialized aquatic and fungal species are among the novel and important findings of this study. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Habeeb Naser, Thoulfikar A. Alamir, Al-Shukarji, Ahmed, Qassem, Kamal, Almeleebia, Alwaily, Hasan Kadhum, Alawadi and Alsalamy.) |
| References: | ChemistryOpen. 2021 Aug;10(8):815-829. (PMID: 34402596) Molecules. 2022 Jul 23;27(15):. (PMID: 35897899) J Agric Food Chem. 2023 Jul 5;71(26):10018-10027. (PMID: 37340708) Eur J Med Chem. 2015 Jun 5;97:786-815. (PMID: 25555743) Molecules. 2021 Aug 18;26(16):. (PMID: 34443583) Eur J Med Chem. 2013 Nov;69:735-53. (PMID: 24099993) |
| فهرسة مساهمة: | Keywords: antimicrobial agent; biological evaluation; choline chloride/urea; deep eutectic solvent; pyrano[2,3-c]pyrazole; pyrazole |
| تواريخ الأحداث: | Date Created: 20240304 Latest Revision: 20240305 |
| رمز التحديث: | 20240305 |
| مُعرف محوري في PubMed: | PMC10904593 |
| DOI: | 10.3389/fchem.2024.1342784 |
| PMID: | 38435668 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-2646 |
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| DOI: | 10.3389/fchem.2024.1342784 |