دورية أكاديمية
Maternal protein supplementation during mid-gestation improves offspring performance and metabolism in beef cows.
| العنوان: | Maternal protein supplementation during mid-gestation improves offspring performance and metabolism in beef cows. |
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| المؤلفون: | Nascimento KB; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Galvão MC; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Meneses JAM; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil.; Department of Medicine Veterinary and Animal Science, Universidad de Ciencias Aplicadas y Ambientales (UDCA), Cartagena, Bolivar 130001, Colombia., Ramírez-Zamudio GD; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Pereira DG; Department of Veterinary Medicine, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Paulino PVR; Cargill Animal Nutrition/Nutron, Campinas, São Paulo 13086-903, Brazil., Casagrande DR; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Gionbelli TRS; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Ladeira MM; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil., Duarte MS; Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada N1G 2W1., Loor JJ; Department of Animal Sciences, Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA., Gionbelli MP; Department of Animal Science, Universidade Federal de Lavras, Lavras, Minas Gerais 37203-202, Brazil. |
| المصدر: | Journal of animal science [J Anim Sci] 2024 Jan 03; Vol. 102. |
| نوع المنشور: | Randomized Controlled Trial, Veterinary; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Animal Science Country of Publication: United States NLM ID: 8003002 Publication Model: Print Cited Medium: Internet ISSN: 1525-3163 (Electronic) Linking ISSN: 00218812 NLM ISO Abbreviation: J Anim Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Champaign, IL : American Society of Animal Science |
| مواضيع طبية MeSH: | Animal Feed*/analysis , Dietary Supplements*/analysis, Animals ; Cattle ; Female ; Pregnancy ; Diet/veterinary ; Minerals ; Muscle, Skeletal ; Male |
| مستخلص: | This study examined the impact of maternal protein supplementation during mid-gestation on offspring, considering potential sex-related effects. Forty-three pregnant purebred Tabapuã beef cows (20 female and 23 male fetuses) were collectively managed in a pasture until 100 d of gestation. From 100 to 200 d of gestation, they were randomly assigned to the restricted group [(RES) - basal diet (75% corn silage + 25% sugar cane bagasse + mineral mixture); n = 24] or control group [(CON) - same basal diet + based-plant supplement [40% of crude protein, 3.5 g/kg of body weight (BW); n = 19]. From 200 d of gestation until parturition, all cows were equally fed corn silage and mineral mixture. During the cow-calf phase, cows and their calves were maintained in a pasture area. After weaning, calves were individually housed and evaluated during the backgrounding (255 to 320 d), growing 1 (321 to 381 d), and growing 2 (382 to 445 d) phases. Offspring's blood samples were collected at 210 and 445 d of age. Samples of skeletal muscle tissue were collected through biopsies at 7, 30, and 445 d of age. Muscle tissue samples were subjected to reverse-transcription quantitative polymerase chain reaction analysis. Prenatal treatment and offspring's sex (when pertinent) were considered fixed effects. The significance level was set at 5%. At mid-gestation, cows supplemented with protein reached 98% and 92% of their protein and energy requirements, while nonsupplemented cows attained only 30% and 50% of these requirements, respectively. The RES offspring were lighter at birth (27 vs. 31 kg), weaning (197 vs. 214 kg), and 445 d of age (398 vs. 429 kg) (P ≤ 0.05). The CON calves had greater (P < 0.05) morphometric measurements overall. The CON offspring had ~26% greater muscle fiber area (P ≤ 0.01). There was a trend (P = 0.06) for a greater Mechanistic target of rapamycin kinase mRNA expression in the Longissimus thoracis in the CON group at 7 d of age. The Myogenic differentiation 1 expression was greater (P = 0.02) in RES-females. Upregulation of Carnitine palmitoyltransferase 2 was observed in RES offspring at 445 d (P = 0.04). Expression of Fatty acid binding protein 4 (P < 0.001), Peroxisome proliferator-activated receptor gamma (P < 0.001), and Stearoyl-Coenzyme A desaturase (P < 0.001) was upregulated in CON-females. Therefore, protein supplementation during gestation enhances offspring growth and promotes favorable responses to lipogenesis, particularly in females. (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
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| فهرسة مساهمة: | Keywords: fetal programming; gene expression; lipogenesis; morphometric measurements; sexual dimorphism Local Abstract: [plain-language-summary] In tropical conditions, beef cows on pasture often experience protein restriction during mid-to-late gestation, potentially impacting offspring development negatively. To address this, we investigated the effects of strategic protein supplementation for pregnant beef cows fed low-quality forage during mid-gestation on the postnatal growth trajectory of their offspring. The supplementation program, implemented during mid-gestation, increased dry matter intake by addressing nitrogen deficiency in the rumen, resulting in meeting 98% and 92% of protein and energy requirements in supplemented cows. In contrast, nonsupplemented cows met only 30% and 50% of these requirements, respectively. Consequently, protein supplementation positively influenced the postnatal growth trajectory of the offspring, attributed to beneficial changes in secondary myogenesis and hypertrophy processes. Supplementing cows with crude protein also stimulated lipogenesis, potentially contributing to intramuscular fat deposition, particularly in females. Therefore, this study emphasizes the importance of nutritional interventions for pregnant beef cows fed low-quality forage. |
| المشرفين على المادة: | 0 (Minerals) |
| تواريخ الأحداث: | Date Created: 20240304 Date Completed: 20240408 Latest Revision: 20240503 |
| رمز التحديث: | 20240503 |
| مُعرف محوري في PubMed: | PMC10998463 |
| DOI: | 10.1093/jas/skae058 |
| PMID: | 38437631 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1525-3163 |
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| DOI: | 10.1093/jas/skae058 |