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MicroRNA-mediated regulation of nonsense-mediated mRNA decay factors: Insights into microRNA prediction tools and profiling techniques.

التفاصيل البيبلوغرافية
العنوان: MicroRNA-mediated regulation of nonsense-mediated mRNA decay factors: Insights into microRNA prediction tools and profiling techniques.
المؤلفون: Yadav P; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India., Tamilselvan R; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India., Mani H; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India., Singh KK; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India. Electronic address: kusumsingh@iitg.ac.in.
المصدر: Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2024 Jun; Vol. 1867 (2), pp. 195022. Date of Electronic Publication: 2024 Mar 02.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4320 (Electronic) Linking ISSN: 18749399 NLM ISO Abbreviation: Biochim Biophys Acta Gene Regul Mech Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier,
مواضيع طبية MeSH: MicroRNAs*/metabolism , MicroRNAs*/genetics , Nonsense Mediated mRNA Decay*, Humans ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/genetics ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Animals ; Gene Expression Regulation
مستخلص: Nonsense-mediated mRNA decay (NMD) stands out as a prominent RNA surveillance mechanism within eukaryotes, meticulously overseeing both RNA abundance and integrity by eliminating aberrant transcripts. These defective transcripts are discerned through the concerted efforts of translating ribosomes, eukaryotic release factors (eRFs), and trans-acting NMD factors, with Up-Frameshift 3 (UPF3) serving as a noteworthy component. Remarkably, in humans, UPF3 exists in two paralogous forms, UPF3A (UPF3) and UPF3B (UPF3X). Beyond its role in quality control, UPF3 wields significant influence over critical cellular processes, including neural development, synaptic plasticity, and axon guidance. However, the precise regulatory mechanisms governing UPF3 remain elusive. MicroRNAs (miRNAs) emerge as pivotal post-transcriptional gene regulators, exerting substantial impact on diverse pathological and physiological pathways. This comprehensive review encapsulates our current understanding of the intricate regulatory nexus between NMD and miRNAs, with particular emphasis on the essential role played by UPF3B in neurodevelopment. Additionally, we bring out the significance of the 3'-untranslated region (3'-UTR) as the molecular bridge connecting NMD and miRNA-mediated gene regulation. Furthermore, we provide an in-depth exploration of diverse computational tools tailored for the prediction of potential miRNA targets. To complement these computational approaches, we delineate experimental techniques designed to validate predicted miRNA-mRNA interactions, empowering readers with the knowledge necessary to select the most appropriate methodology for their specific research objectives.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Experimental validation; Gene regulation; Nonsense-mediated mRNA decay; Prediction tools; Up-frameshift 3; miRNA
المشرفين على المادة: 0 (UPF3A protein, human)
0 (UPF3B protein, human)
تواريخ الأحداث: Date Created: 20240304 Date Completed: 20240516 Latest Revision: 20240516
رمز التحديث: 20240517
DOI: 10.1016/j.bbagrm.2024.195022
PMID: 38437914
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-4320
DOI:10.1016/j.bbagrm.2024.195022