دورية أكاديمية
Evaluation of the structural integrity of different spinal cord tracts with magnetization transfer ratio in degenerative cervical myelopathy.
| العنوان: | Evaluation of the structural integrity of different spinal cord tracts with magnetization transfer ratio in degenerative cervical myelopathy. |
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| المؤلفون: | Filimonova E; FSBI 'Federal Center of Neurosurgery', Novosibirsk, Russia. e.filimonova@alumni.nsu.ru.; Department of Neurosurgery, Novosibirsk State Medical University, Novosibirsk, Russia. e.filimonova@alumni.nsu.ru., Abdaev M; FSBI 'Federal Center of Neurosurgery', Novosibirsk, Russia., Vasilenko I; FSBI 'Federal Center of Neurosurgery', Novosibirsk, Russia., Kubetskij Y; FSBI 'Federal Center of Neurosurgery', Novosibirsk, Russia., Prokhorov O; Novosibirsk State University, Novosibirsk, Russia., Rzaev J; FSBI 'Federal Center of Neurosurgery', Novosibirsk, Russia.; Department of Neurosurgery, Novosibirsk State Medical University, Novosibirsk, Russia.; Novosibirsk State University, Novosibirsk, Russia. |
| المصدر: | Neuroradiology [Neuroradiology] 2024 May; Vol. 66 (5), pp. 839-846. Date of Electronic Publication: 2024 Mar 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 1302751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1920 (Electronic) Linking ISSN: 00283940 NLM ISO Abbreviation: Neuroradiology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | White Matter* , Spinal Cord Diseases*/diagnostic imaging , Cervical Cord*/diagnostic imaging , Spinal Cord Compression*, Humans ; Spinal Cord/diagnostic imaging ; Spinal Cord/pathology ; Magnetic Resonance Imaging/methods ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/pathology |
| مستخلص: | Purpose: Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction. In this study, we explored the potential of magnetization transfer ratio (MTR) for evaluating the structural integrity of spinal cord tracts in patients with clinically significant DCM. Methods: Fifty-three patients with DCM and 41 patients with cervical radiculopathy were evaluated using high-resolution cervical spinal cord magnetic resonance imaging (MRI), which included the magnetization transfer technique. MRI data were analyzed with the Spinal Cord Toolbox (v5.5); MTR values in each spinal tract were calculated and compared between groups after correction for patient age and sex. Correlations between MTR values and patients' clinical disability rate were also evaluated. Results: A statistically significant reduction in the average MTR of the spinal cord white matter, as well as the MTR of the ventral columns and lateral funiculi, was revealed in the DCM group (adjusted p < 0.01 for all comparisons). Furthermore, reductions in MTR values in the fasciculus cuneatus, spinocerebellar, rubrospinal, and reticulospinal tracts were found in patients with DCM (adjusted p < 0.01 for all comparisons). Positive correlations between the JOA score and the MTR within the ventral columns of the spinal cord (R = 0.38, adjusted p < 0.05) and the ventral spinocerebellar tract (R = 0.41, adjusted p < 0.05) were revealed. Conclusion: The findings of our study indicate that demyelination in patients with DCM primarily affects the spinal tracts of the extrapyramidal system, and the extent of these changes is related to the severity of the condition. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Degenerative cervical myelopathy; MR-morphometry; Magnetization transfer ratio (MTR); Spinal Cord Toolbox |
| تواريخ الأحداث: | Date Created: 20240305 Date Completed: 20240422 Latest Revision: 20240422 |
| رمز التحديث: | 20240422 |
| DOI: | 10.1007/s00234-024-03327-w |
| PMID: | 38441573 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1920 |
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| DOI: | 10.1007/s00234-024-03327-w |