دورية أكاديمية
Trinucleotide mRNA Cap Analogue N 6-Benzylated at the Site of Posttranscriptional m6 A m Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo.
العنوان: | Trinucleotide mRNA Cap Analogue N 6-Benzylated at the Site of Posttranscriptional m6 A |
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المؤلفون: | Warminski M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland., Trepkowska E; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Smietanski M; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Sikorski PJ; Centre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.; Laboratory of Epitranscriptomics, Department of Environmental Microbiology and Biotechnology, Institute of Microbiology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, 02-089 Warsaw, Poland., Baranowski MR; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Bednarczyk M; Centre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Kedzierska H; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Majewski B; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Mamot A; Centre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland., Papiernik D; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Popielec A; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Serwa RA; Proteomics Core Facility, IMol Polish Academy of Sciences, 02-247 Warsaw, Poland., Shimanski BA; Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States., Sklepkiewicz P; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Sklucka M; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Sokolowska O; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Spiewla T; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Toczydlowska-Socha D; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Warminska Z; Centre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland., Wolosewicz K; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Zuberek J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland., Mugridge JS; Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States., Nowis D; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.; Laboratory of Experimental Medicine, Faculty of Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland., Golab J; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.; Laboratory of Experimental Medicine, Faculty of Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland., Jemielity J; Centre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland., Kowalska J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.; Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland. |
المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2024 Mar 27; Vol. 146 (12), pp. 8149-8163. Date of Electronic Publication: 2024 Mar 05. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
مواضيع طبية MeSH: | RNA Caps*/chemistry , RNA Caps*/genetics , RNA Caps*/metabolism , Vaccines*, Animals ; Mice ; RNA, Messenger/genetics ; Protein Biosynthesis ; Methylation |
مستخلص: | Eukaryotic mRNAs undergo cotranscriptional 5'-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as m6 A |
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معلومات مُعتمدة: | R35 GM143000 United States GM NIGMS NIH HHS; T32 GM133395 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (RNA, Messenger) 0 (RNA Caps) 0 (Vaccines) |
تواريخ الأحداث: | Date Created: 20240305 Date Completed: 20240328 Latest Revision: 20240710 |
رمز التحديث: | 20240710 |
مُعرف محوري في PubMed: | PMC10979456 |
DOI: | 10.1021/jacs.3c12629 |
PMID: | 38442005 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-5126 |
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DOI: | 10.1021/jacs.3c12629 |