دورية أكاديمية
The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats.
| العنوان: | The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats. |
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| المؤلفون: | Rahimi K; Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Ezzati Givi M; Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Rezaie A; Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Hekmatmanesh M; Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Shaker Ardakani Y; Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. |
| المصدر: | The British journal of nutrition [Br J Nutr] 2024 Jun 14; Vol. 131 (11), pp. 1844-1851. Date of Electronic Publication: 2024 Mar 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: [Cambridge, New York] Cambridge University Press. |
| مواضيع طبية MeSH: | Stomach Ulcer*/chemically induced , Stomach Ulcer*/prevention & control , Stomach Ulcer*/drug therapy , Indomethacin*/adverse effects , Antioxidants*/pharmacology , Oxidative Stress*/drug effects , gamma-Linolenic Acid*/pharmacology , Rats, Wistar* , Dinoprostone*/metabolism, Animals ; Rats ; Male ; Gastric Mucosa/drug effects ; Gastric Mucosa/pathology ; Gastric Mucosa/metabolism ; Interleukin-6/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Superoxide Dismutase/metabolism ; Anti-Ulcer Agents/pharmacology ; Anti-Ulcer Agents/therapeutic use ; Glutathione/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Anti-Inflammatory Agents/pharmacology ; Cyclooxygenase 1/metabolism ; Malondialdehyde/metabolism ; Omeprazole/pharmacology |
| مستخلص: | The primary goal of the investigation was to analyse the anti-inflammatory and antioxidant properties of Gamma-linolenic acid (GLA) on rats with indomethacin (IND)-induced gastric ulcers. Thirty rats were divided into five groups: Control, IND (50 mg/kg, p.o.), IND pretreated with GLA 100 mg/kg (p.o. for 14 d), IND pretreated with GLA 150 mg/kg (p.o. for 14 d) and IND pretreated with omeprazole (20 mg/kg, p.o. for 14 d). The stomach tissues were examined to calculate the ulcer index and pH and analyse biochemical markers (prostaglandin E2 (PGE2), cyclooxygenase 1 (COX1), TNF-1, IL-6 and intercellular adhesion molecule-1 (ICAM1)) and oxidative stress parameters (malondialdehyde: (MDA), superoxide dismutase (SOD), glutathione (GSH) and CAT (catalase)) as well as undergo histopathological assessment. GLA 100 and 150 mg/kg showed a protective effect against IND-induced gastric damage. It reduced levels of COX1, TNF-1, IL-6 and ICAM and increased PGE2 levels. GLA also normalised antioxidant function by modulating MDA, SOD, GSH and CAT. GLA intervention protects against IND-induced gastric ulcers by restoring oxidant/antioxidant balance and reducing inflammation. |
| فهرسة مساهمة: | Keywords: Gamma-linolenic acid; Gastric ulcer; Indomethacin; Rat |
| المشرفين على المادة: | XXE1CET956 (Indomethacin) 0 (Antioxidants) 78YC2MAX4O (gamma-Linolenic Acid) K7Q1JQR04M (Dinoprostone) 0 (Interleukin-6) 126547-89-5 (Intercellular Adhesion Molecule-1) EC 1.15.1.1 (Superoxide Dismutase) 0 (Anti-Ulcer Agents) GAN16C9B8O (Glutathione) 0 (Tumor Necrosis Factor-alpha) 0 (Anti-Inflammatory Agents) EC 1.14.99.1 (Cyclooxygenase 1) 4Y8F71G49Q (Malondialdehyde) KG60484QX9 (Omeprazole) |
| تواريخ الأحداث: | Date Created: 20240305 Date Completed: 20240523 Latest Revision: 20240523 |
| رمز التحديث: | 20240523 |
| DOI: | 10.1017/S0007114524000382 |
| PMID: | 38443203 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2662 |
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| DOI: | 10.1017/S0007114524000382 |