دورية أكاديمية
أعرض في EDS

Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study.

التفاصيل البيبلوغرافية
العنوان: Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study.
المؤلفون: Burling JE; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA., Katz Z; Washington University School of Medicine in St. Louis (ZK), St. Louis, MO., Yuan Z; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA., Munro C; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Department of Psychiatry (CM, YTQ, DB, JRG), Massachusetts General Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Mimmack K; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA., Ma G; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA; Department of Psychiatry (GM), Brigham and Women's Hospital, Boston, MA., Hanseeuw BJ; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA; Department of Radiology (BJH), Massachusetts General Research Institute, Boston, MA; Department of Neurology (BJH), Cliniques Universitaires Saint-Luc, Brussels, Belgium., Papp KV; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Amariglio RE; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Vannini P; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Rentz DM; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Quiroz YT; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Psychiatry (CM, YTQ, DB, JRG), Massachusetts General Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Johnson KA; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA; Department of Radiology (KAJ), Massachusetts General Hospital, Boston, MA., Sperling RA; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Blacker D; Department of Psychiatry (CM, YTQ, DB, JRG), Massachusetts General Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA; Department of Epidemiology (DB), Harvard T. H. Chan School of Public Health, Boston, MA., Marshall GA; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Yang HS; Department of Neurology (JEB, ZY, KM, KVP, REA, PV, DMR, YTQ, KAJ, RAS, GAM, H-SY), Massachusetts General Hospital, Boston, MA; Department of Neurology (CM, KVP, REA, PV, DMR, KAJ, RAS, GAM, H-SY), Brigham and Women's Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA., Gatchel JR; Department of Psychiatry (CM, YTQ, DB, JRG), Massachusetts General Hospital, Boston, MA; Harvard Medical School (CM, GM, BJH, KVP, REA, PV, DMR, YTQ, KAJ, RAS, DB, GAM, H-SY, JRG), Boston, MA; Department of Psychiatry (JRG), Massachusetts General Hospital, Boston MA; Department of Psychiatry (JRG), McLean Hospital, Belmont, MA; Department of Psychiatry (JRG), Baylor College of Medicine, Houston, TX; Michael E. DeBakey VA Medical Center (JRG), Houston, TX. Electronic address: jgatchel@partners.org.
المصدر: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2024 Aug; Vol. 32 (8), pp. 909-919. Date of Electronic Publication: 2024 Jan 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9309609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-7214 (Electronic) Linking ISSN: 10647481 NLM ISO Abbreviation: Am J Geriatr Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2013- : London : Elsevier
Original Publication: Washington, DC : American Psychiatry Press
مواضيع طبية MeSH: Apathy*/physiology , Alzheimer Disease*/diagnostic imaging , Alzheimer Disease*/metabolism , Biomarkers*/metabolism , Positron-Emission Tomography* , tau Proteins*/metabolism , Aging*/metabolism , Aging*/psychology, Humans ; Male ; Female ; Aged ; Longitudinal Studies ; Aged, 80 and over ; Cross-Sectional Studies ; Brain/diagnostic imaging ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Self Report
مستخلص: Objectives: We examined relationships between apathy (self and study-partner-reported) and markers of Alzheimer's disease (AD) in older adults.
Design: The study utilized a well-characterized sample of participants from the Harvard Aging Brain Study (HABS), a longitudinal cohort study. Participants were cognitively unimpaired without clinically significant neuropsychiatric symptoms at HABS baseline. The dependent variables, apathy evaluation scale-self (AES-S) and informant (AES-I), were administered cross-sectionally between years 6-9 and compared to the independent variables, amyloid and tau PET neuroimaging, from the same year.
Setting: Community-dwelling participants assessed at research visits in an academic medical center.
Participants: Participants (n = 170) completed assessments within 1.5 years of their neuroimaging visit. At the time of apathy assessment, N = 156 were cognitively unimpaired and 14 had progressed to mild cognitive impairment (n = 8) or dementia (n = 6).
Measurements: We utilized linear regression models to assess cross-sectional associations of AES-S and AES-I with AD PET imaging measures (beta-amyloid (Pittsburgh Compound B) and tau (Flortaucipir)), covarying for age, sex, education, and the time between PET scan-apathy assessment.
Results: AES-I was significantly associated with beta-amyloid and temporal lobe tau, and the associations were retained after further adjusting for depressive symptoms. The associations between AES-S and AD biomarkers were not significant. In an exploratory subgroup analysis of cognitively unimpaired individuals with elevated Aβ, we observed an association between AES-I and inferior temporal tau.
Conclusions: Study-partner-reported, but not self-reported, apathy in older adults is associated with AD pathology, and we observed this relationship starting from the preclinical stage. Our findings highlight the importance of collateral information in capturing AD-related apathy.
Competing Interests: DISCLOSURES Dr. Gad Marshall receives salary support from NIH/NIA R01 AG071074, R01 AG067021, R01 AG053184, R21 AG064413, R42 AG069629, and R21 AG070877. Dr. Marshall also receives salary support for serving as site principal investigator for clinical trials funded by Eisai Inc., Eli Lilly and Company, and Genentech. These relationships are not related to the content in the manuscript. Dr. Catherine Munro has a research fellowship from the Alzheimer's Association (AARF-23-1150240). This relationship is not related to the content in the manuscript. Dr. Jennifer Gatchel receives salary support from NIH/NIA K23AG05880, NIH/NIA R01AG07819. She is paid from the MEDVAMC. These relationships are not relevant to the content of the manuscript. Dr. Kathryn Papp receives support in the form of consulting fees from Cogstate and Novoic. These relationships are not relevant to the content of the manuscript. Dr. Hyun-Sik Yang receives salary support from NIH/NIA K23AG062750 and NIH/NIA R01AG080667. This relationship is not relevant to the content of the manuscript. Zoe Katz received support from R01AG065234 in the last 36 months. This relationship is not relevant to the content of the manuscript. Dr. Dorene Rentz receives payments from AAAS and IMPACT AD for lectures/speakership events. She also participates on a Data Safety Monitoring/Advisory Board for Washington University, Northwestern, UC-Davis, and Boston University. These relationships are not relevant to the content of the manuscript. Dr. Keith Johnson receives support from the following: NIH-NIA 5R01AG046396-05. Moreover, he is paid as a consultant for Merck and Novartis. These relationships are not relevant to the content of the manuscript. Dr. Reisa Sperling receives support from the NIH (P01AG036694) as funding to institution. She also has the following grants/contracts: Alzheimer's Association (to institution), NIA (to institution), GHR foundation (to institution), Eli Lilly (research funding on clinical trial sites), Eisai (research funding on clinical trial sites). Moreover, she is paid directly as a consultant for the following companies: AC Immunce, Acumen, Alector, Alnylam, Genetech, Janssen, JOMDD, Nervgen, Neuraly, Neurocentria, Oligomerix, Prothena, Renew, Shionogi, Vigil Neuroscience, Ionis, Vaxxinity, Bristol Myers Squibb. These relationships are not related to the content in the manuscript. Dr. Yakeel Quiroz receives support from the following grants/contracts: Alzheimer's Association, NIA, Massachusetts General Hospital ECOR which are all paid to her institution. She also has payment support from Biogen. These relationships are not related to the content in the manuscript.
(Copyright © 2024. Published by Elsevier Inc.)
التعليقات: Comment in: Am J Geriatr Psychiatry. 2024 Aug;32(8):920-921. doi: 10.1016/j.jagp.2024.03.017. (PMID: 38658231)
معلومات مُعتمدة: K23 AG058805 United States AG NIA NIH HHS; P01 AG036694 United States AG NIA NIH HHS; R01 AG078191 United States AG NIA NIH HHS; P50 AG005134 United States AG NIA NIH HHS; K23 AG058800 United States AG NIA NIH HHS; R01 AG007819 United States AG NIA NIH HHS; K23 AG062750 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Alzheimer's disease; Apathy; amyloid; positron emission tomography; study-partner-report; tau
المشرفين على المادة: 0 (Biomarkers)
0 (tau Proteins)
0 (Amyloid beta-Peptides)
تواريخ الأحداث: Date Created: 20240305 Date Completed: 20240706 Latest Revision: 20240724
رمز التحديث: 20240725
DOI: 10.1016/j.jagp.2024.01.020
PMID: 38443298
قاعدة البيانات: MEDLINE
الوصف
تدمد:1545-7214
DOI:10.1016/j.jagp.2024.01.020