دورية أكاديمية
Bioinformatics analysis of the microRNA genes associated with type 2 cardiorenal syndrome.
| العنوان: | Bioinformatics analysis of the microRNA genes associated with type 2 cardiorenal syndrome. |
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| المؤلفون: | Zong Y; Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.; Department of Cardiovascular Medicine, Nanjing Chest Hospital, Nanjing, China., Hu Y; Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.; Department of Cardiovascular Medicine, Nanjing Chest Hospital, Nanjing, China., Zheng M; Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.; Department of Cardiovascular Medicine, Nanjing Chest Hospital, Nanjing, China., Wang Z; Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China. wangzhi1977nj@126.com.; Department of Cardiovascular Medicine, Nanjing Chest Hospital, Nanjing, China. wangzhi1977nj@126.com.; Department of Cardiology Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu, 210029, China. wangzhi1977nj@126.com. |
| المصدر: | BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Mar 05; Vol. 24 (1), pp. 142. Date of Electronic Publication: 2024 Mar 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Cardio-Renal Syndrome*/diagnosis , Cardio-Renal Syndrome*/genetics , MicroRNAs*/genetics , Circulating MicroRNA*, Humans ; Kidney ; Heart ; Computational Biology |
| مستخلص: | Background: MicroRNAs (miRNAs) are important regulatory factors in the normal developmental stages of the heart and kidney. However, it is currently unclear how miRNA is expressed in type 2 cardiorenal syndrome (CRS). This study aimed to detect the differential expression of miRNAs and to clarify the main enrichment pathways of differentially expressed miRNA target genes in type 2 CRS. Methods: Five cases of healthy control (Group 1), eight of chronic heart failure (CHF, Group 2) and seven of type 2 CRS (Group 3) were enrolled, respectively. Total RNA was extracted from the peripheral blood of each group. To predict the miRNA target genes and biological signalling pathways closely related to type 2 CRS, the Agilent miRNA microarray platform was used for miRNA profiling and bioinformatics analysis of the isolated total RNA samples. Results: After the microarray analysis was done to screen for differentially expressed circulating miRNAs among the three different groups of samples, the target genes and bioinformatic pathways of the differential miRNAs were predicted. A total of 38 differential miRNAs (15 up- and 23 down-regulated) were found in Group 3 compared with Group 1, and a total of 42 differential miRNAs (11 up- and 31 down-regulated) were found in Group 3 compared to Group 2. According to the Gene Ontology (GO) function and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analysis, the top 10 lists of molecular functions, cellular composition and biological processes, and the top 30 signalling pathways of predicted gene targets of the differentially expressed miRNAs were discriminated among the three groups. Conclusion: Between the patients with CHF and type 2 CRS, miRNAs were differentially expressed. Prediction of target genes of differentially expressed miRNAs and the use of GO function and KEGG pathway analysis may reveal the molecular mechanisms of CRS. Circulating miRNAs may contribute to the diagnosis of CRS, and further and larger studies are needed to enhance the robustness of our findings. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | BK20211019 Natural Science Foundation of Jiangsu Province |
| فهرسة مساهمة: | Keywords: Bioinformatics; Cardiorenal syndrome; MicroRNAs |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (Circulating MicroRNA) |
| تواريخ الأحداث: | Date Created: 20240305 Date Completed: 20240307 Latest Revision: 20240308 |
| رمز التحديث: | 20240308 |
| مُعرف محوري في PubMed: | PMC10913659 |
| DOI: | 10.1186/s12872-024-03816-z |
| PMID: | 38443814 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1471-2261 |
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| DOI: | 10.1186/s12872-024-03816-z |