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Causality of blood metabolites and metabolic pathways on Graves' disease and Graves' ophthalmopathy: a two-sample Mendelian randomization study.

التفاصيل البيبلوغرافية
العنوان: Causality of blood metabolites and metabolic pathways on Graves' disease and Graves' ophthalmopathy: a two-sample Mendelian randomization study.
المؤلفون: Wang T; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Zhang Y; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Wu C; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Yang H; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Luo Z; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. zluo888@163.com.
المصدر: Endocrine [Endocrine] 2024 Aug; Vol. 85 (2), pp. 786-793. Date of Electronic Publication: 2024 Mar 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE
أسماء مطبوعة: Publication: Feb. 1996- : Totowa, NJ : Humana Press
Original Publication: Houndsmills, Basingstoke, Hants, UK : Macmillan Press, c1994-
مواضيع طبية MeSH: Mendelian Randomization Analysis* , Graves Ophthalmopathy*/blood , Graves Ophthalmopathy*/genetics , Graves Disease*/genetics , Graves Disease*/blood , Metabolic Networks and Pathways*/genetics, Humans ; Biomarkers/blood
مستخلص: Objectives: There is ample that metabolic dysregulation is involved in Graves' disease (GD) and Graves' ophthalmopathy (GO). Recent studies have identified numerous metabolites associated with GD and GO. However, the causal impact of metabolites on GD and GO remains to be investigated.
Methods: This two-sample Mendelian randomization (MR) analysis investigated the causal relationships between 486 blood metabolites and GD and GO. Sensitivity analysis was also performed to examine heterogeneity and pleiotropy.
Results: MR analysis showed that 9 and 13 metabolites were associated with GD and GO, respectively, each meeting the nominal significance criteria (inverse variance weighted, p < 0.05). Additionally, four metabolic pathways were identified for each condition using network-based MetaboAnalyst 5.0.
Conclusions: The metabolites and pathways discovered in this study could serve as circulating metabolic biomarkers for clinical screening and prevention of GD and GO. They can be also used for further studies on the mechanisms and drug targets in GD and GO.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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معلومات مُعتمدة: 82260159 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Graves’ disease (GD); Graves’ ophthalmopathy (GO); Mendelian randomization (MR); Metabolites
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240306 Date Completed: 20240731 Latest Revision: 20240731
رمز التحديث: 20240731
DOI: 10.1007/s12020-024-03761-z
PMID: 38448677
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0100
DOI:10.1007/s12020-024-03761-z