دورية أكاديمية
Mitochondrial ATP generation is more proteome efficient than glycolysis.
| العنوان: | Mitochondrial ATP generation is more proteome efficient than glycolysis. |
|---|---|
| المؤلفون: | Shen Y; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Dinh HV; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA., Cruz ER; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Chen Z; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA., Bartman CR; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA., Xiao T; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Call CM; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Ryseck RP; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Pratas J; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Weilandt D; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Baron H; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Subramanian A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Fatma Z; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Wu ZY; US Department of Energy Joint Genome Institute and Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Dwaraknath S; US Department of Energy Joint Genome Institute and Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Hendry JI; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA., Tran VG; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Yang L; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Yoshikuni Y; US Department of Energy Joint Genome Institute and Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Zhao H; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Maranas CD; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA., Wühr M; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. wuhr@princeton.edu.; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. wuhr@princeton.edu., Rabinowitz JD; Department of Chemistry, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA. joshr@princeton.edu. |
| المصدر: | Nature chemical biology [Nat Chem Biol] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature Pub. Group, [2005]- |
| مستخلص: | Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is more energy efficient, some cells favor glycolysis even when oxygen is available (aerobic glycolysis, Warburg effect). A leading explanation is that glycolysis is more efficient in terms of ATP production per unit mass of protein (that is, faster). Through quantitative flux analysis and proteomics, we find, however, that mitochondrial respiration is actually more proteome efficient than aerobic glycolysis. This is shown across yeast strains, T cells, cancer cells, and tissues and tumors in vivo. Instead of aerobic glycolysis being valuable for fast ATP production, it correlates with high glycolytic protein expression, which promotes hypoxic growth. Aerobic glycolytic yeasts do not excel at aerobic growth but outgrow respiratory cells during oxygen limitation. We accordingly propose that aerobic glycolysis emerges from cells maintaining a proteome conducive to both aerobic and hypoxic growth. (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.) |
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| معلومات مُعتمدة: | R35 GM128813 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20240306 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| DOI: | 10.1038/s41589-024-01571-y |
| PMID: | 38448734 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41589-024-01571-y |