دورية أكاديمية
Interobserver agreement in the interpretation of anal cytology.
| العنوان: | Interobserver agreement in the interpretation of anal cytology. |
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| المؤلفون: | Benevolo M; Pathology Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Rollo F; Pathology Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Latini A; Sexually Transmitted Infection/Human Immunodeficiency Virus Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Giuliani M; Sexually Transmitted Infection/Human Immunodeficiency Virus Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Giglio A; Microbiology and Virology, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Giuliani E; Sexually Transmitted Infection/Human Immunodeficiency Virus Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Donà MG; Sexually Transmitted Infection/Human Immunodeficiency Virus Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy. |
| المصدر: | Cancer cytopathology [Cancer Cytopathol] 2024 Jul; Vol. 132 (7), pp. 419-424. Date of Electronic Publication: 2024 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101499453 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6638 (Electronic) Linking ISSN: 1934662X NLM ISO Abbreviation: Cancer Cytopathol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : Wiley-Blackwell |
| مواضيع طبية MeSH: | Anus Neoplasms*/virology , Anus Neoplasms*/pathology , Anus Neoplasms*/diagnosis , Observer Variation* , Papillomavirus Infections*/virology , Papillomavirus Infections*/diagnosis , Papillomavirus Infections*/pathology , Cytodiagnosis*/methods , Homosexuality, Male*/statistics & numerical data, Humans ; Male ; Adult ; Middle Aged ; Papillomaviridae/isolation & purification ; Papillomaviridae/genetics ; Anal Canal/virology ; Anal Canal/pathology ; Reproducibility of Results ; Young Adult ; Early Detection of Cancer/methods ; Aged ; Cytology |
| مستخلص: | Background: Anal cytology represents a tool for anal cancer screening in high-risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation between two cytopathologists. Methods: Liquid-based cytologic slides from human immunodeficiency virus (HIV)-negative men who have sex with men (MSM) were evaluated by two readers with at least 10 years of expertise in cervical cytology. Cases with a discordant interpretation were reviewed, and a consensus was reached. Human papillomavirus (HPV) genotyping was performed using a proprietary HPV genotyping test. Unweighted and weighted Cohen kappa and 95% confidence interval (CI) values were calculated. Results: Overall, 713 slides that were adequate for interpretation were evaluated (MSM: median age, 33 years). An HPV test was performed on 620 samples (87.0%). Considering a dichotomous interpretation (negative for intraepithelial lesion or malignancy vs. atypical squamous cells of undetermined significance or worse), the crude agreement between the two readers was 93.3% (kappa = 0.82; 95% CI, 0.77-0.87). Once a consensus for discordant cases was reached, the best agreement was found for the negative for intraepithelial lesion or malignancy category (511 of 528 samples; 96.8%), whereas the atypical squamous cells of undetermined significance category showed the lowest agreement (90 of 117 samples, 76.9%). Considering the individual cytologic categories, overall agreement was 92.1% (kappa = 0.85; 95% CI, 0.81-0.89). The discordant interpretations were not associated with high-risk HPV infection, HPV16 infection, or MSM age. Conclusions: The results indicating excellent interobserver agreement in this study substantiate the use of anal cytology in the setting of human immunodeficiency virus-negative MSM. (© 2024 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society.) |
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| فهرسة مساهمة: | Keywords: anal cytology; cytology interpretation; human papillomavirus (HPV); interobserver agreement |
| تواريخ الأحداث: | Date Created: 20240307 Date Completed: 20240701 Latest Revision: 20240701 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1002/cncy.22807 |
| PMID: | 38451011 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1934-6638 |
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| DOI: | 10.1002/cncy.22807 |