دورية أكاديمية
Neuromodulation with aerobic exercise reduces fatigue in systemic lupus erythematosus: a randomised, sham-controlled, double-blind study.
| العنوان: | Neuromodulation with aerobic exercise reduces fatigue in systemic lupus erythematosus: a randomised, sham-controlled, double-blind study. |
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| المؤلفون: | de Andrade VP; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Dos Santos AM; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Seguro LPC; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Yuki EFN; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Lopes MRU; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Grecco MV; Laboratory for the Study of Movement, Institute of Orthopaedics and Traumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil., Borba EF; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Greve JMA; Laboratory for the Study of Movement, Institute of Orthopaedics and Traumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil., Shinjo SK; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil. samuel.shinjo@usp.br. |
| المصدر: | Clinical and experimental rheumatology [Clin Exp Rheumatol] 2024 Jul; Vol. 42 (7), pp. 1451-1458. Date of Electronic Publication: 2024 Mar 07. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0392-856X (Print) Linking ISSN: 0392856X NLM ISO Abbreviation: Clin Exp Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Pisa : Clinical And Experimental Rheumatology S.A.S Original Publication: Pisa, Italy : Pacini editore, [1983- |
| مواضيع طبية MeSH: | Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/therapy , Lupus Erythematosus, Systemic*/physiopathology , Lupus Erythematosus, Systemic*/diagnosis , Fatigue*/etiology , Fatigue*/therapy , Fatigue*/physiopathology , Transcranial Direct Current Stimulation*, Humans ; Double-Blind Method ; Female ; Adult ; Middle Aged ; Treatment Outcome ; Exercise Therapy/methods ; Exercise ; Severity of Illness Index ; Time Factors ; Sleep Quality |
| مستخلص: | Objectives: Transcranial direct current stimulation (tDCS) combined with aerobic exercise (tDCS-AE) effectively reduces fatigue in patients with fibromyalgia. However, no study has assessed this method in systemic lupus erythematosus (SLE) patients with significant fatigue. Therefore, we evaluated the safety and efficacy of tDCS-AE for significant fatigue symptoms in adult female SLE patients. Methods: This randomised, sham-controlled, double-blind study included 25 patients with SLE in remission or low disease activity (SLEDAI-2K £4) and with significant fatigue [≥36 points on the Fatigue Severity Scale (FSS) or ≥38 points on the Modified Fatigue Scale (MFIS)]. The patients received sham or tDCS for five consecutive days. The anode and cathode were positioned at M1 and Fp2, respectively (international 10-20 EEG system). tDCS was applied at an intensity of 2mA, and density of 0.057mA/cm2 in the tDCS-AE group. Both groups underwent combined low-intensity treadmill exercise. FSS, MFIS, pain visual analogue scale, physical activity, and sleep quality were evaluated at baseline and on days 7, 30, and 60. Adherence and safety were assessed using a standardised questionnaire. Results: Improvement in fatigue levels was observed in both groups. However, a sustained reduction in fatigue levels on days 30 and 60 occurred only with tDCS-AEs (p<0.05). No significant differences were observed in pain level, sleep quality, or physical activity. No disease flares occurred and the adverse effects were mild and transient. Finally, the patient's adherence to the treatment was satisfactory. Conclusions: Despite isolated AEs, there was an improvement in fatigue, however, only tDCS-AE maintained significant and sustained improvement. |
| تواريخ الأحداث: | Date Created: 20240307 Date Completed: 20240719 Latest Revision: 20240722 |
| رمز التحديث: | 20240723 |
| DOI: | 10.55563/clinexprheumatol/yvrdgm |
| PMID: | 38451142 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0392-856X |
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| DOI: | 10.55563/clinexprheumatol/yvrdgm |