دورية أكاديمية
Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis.
| العنوان: | Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis. |
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| المؤلفون: | Aboushaala K; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Chee AV; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA. ana_chee@rush.edu., Toro SJ; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Vucicevic R; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Yuh C; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Dourdourekas J; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Patel IK; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Espinoza-Orias A; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Oh C; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Al-Harthi L; Department of Microbial Pathogens and Immunity, Rush Medical College, Chicago, IL, USA., Karppinen J; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Goldberg EJ; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Phillips FM; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Colman M; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Williams FMK; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA.; Department of Twins Research and Genetic Epidemiology, King's College, London, UK., Borgia JA; Departments of Anatomy & Cell Biology and Pathology, Rush Medical College, Chicago, IL, USA., Green S; Department of Internal Medicine, Rush Medical College, Chicago, IL, USA., Forsyth C; Department of Internal Medicine, Rush Medical College, Chicago, IL, USA., An HS; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA., Samartzis D; Department of Orthopedic Surgery, Rush Medical College, 1611 W. Harrison St, Chicago, IL, 60612, USA. Dino_Samartzis@rush.edu. |
| المصدر: | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2024 Apr; Vol. 33 (4), pp. 1398-1406. Date of Electronic Publication: 2024 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9301980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0932 (Electronic) Linking ISSN: 09406719 NLM ISO Abbreviation: Eur Spine J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg, Federal Republic of Germany : Springer-Verlag, c1992- |
| مواضيع طبية MeSH: | Intervertebral Disc Degeneration* , Intervertebral Disc Displacement*/surgery, Humans ; Prospective Studies ; Cross-Sectional Studies ; Ligands ; Lumbar Vertebrae/surgery ; Biomarkers ; Magnetic Resonance Imaging ; Chemokines |
| مستخلص: | Purpose: The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC). Methods: A cross-sectional sub-analyses of a prospective cohort was performed. Fasting blood samples were collected from patients with and without lumbar MC who had undergone spinal fusion or microdiscectomy. An 80-plex panel and CCL5/RANTES were used to assess preoperative plasma cytokine concentrations. Patient demographics and imaging phenotypes were also assessed. Results: Thirty-one subjects were analysed (n = 18 no MC; n = 13 MC). No significant differences were found in age, sex, body mass index, smoking and alcohol history, and surgical procedure (i.e. fusion, decompression) between the two groups (p > 0.05). Several statistically significant blood biomarkers in MC patients were identified, including elevated levels of C-C Motif Chemokine Ligand 5 (CCL5, p = 0.0006), while Macrophage Migration Inhibitory Factor (MIF) was significantly lower (p = 0.009). Additionally, C-X-C Motif Chemokine Ligand 5 (CXCL5, p = 0.052), Pentraxin 3 (PTX3, p = 0.06) and Galectin-3 (Gal-3, p = 0.07) showed potential relevance. Moreover, MC patients exhibited significantly higher levels of disc degeneration (p = 0.0001) and displacement severity (p = 0.020). Based on multivariate analyses and controlling for disc degeneration/displacement, CCL5 (OR 1.02; 95% CI 1.002-1.033; p = 0.028) and MIF (OR 0.60; 95% CI 0.382-0.951; p = 0.030) were independently associated with MC patients. Conclusion: This "proof-of-concept" study is the first to identify specific and significantly circulating blood biomarkers associated with symptomatic patients with lumbar MC, independent of disc alterations of degeneration and/or bulges/herniations. Specifically, differences in CCL5 and MIF protein levels were significantly noted in MC patients compared to those without MC. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | R21 AR079679 United States AR NIAMS NIH HHS |
| فهرسة مساهمة: | Keywords: Biomarkers; Changes; Disc degeneration; Disc herniation; Endplate; Imaging; MRI; Modic |
| المشرفين على المادة: | 0 (Ligands) 0 (Biomarkers) 0 (Chemokines) |
| تواريخ الأحداث: | Date Created: 20240307 Date Completed: 20240408 Latest Revision: 20240408 |
| رمز التحديث: | 20240408 |
| DOI: | 10.1007/s00586-024-08192-y |
| PMID: | 38451373 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-0932 |
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| DOI: | 10.1007/s00586-024-08192-y |