دورية أكاديمية
أعرض في EDS

Cofilactin rod formation mediates inflammation-induced neurite degeneration.

التفاصيل البيبلوغرافية
العنوان: Cofilactin rod formation mediates inflammation-induced neurite degeneration.
المؤلفون: Uruk G; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Neurology Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., Mocanu E; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Neurology Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., Shaw AE; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Bamburg JR; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Swanson RA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Neurology Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA. Electronic address: raymond.swanson@ucsf.edu.
المصدر: Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113914. Date of Electronic Publication: 2024 Mar 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Neurites* , Neurodegenerative Diseases*, Mice ; Animals ; Neurons ; Axons ; Inflammation
مستخلص: Stroke, trauma, and neurodegenerative disorders cause loss of neurites (axons and dendrites) in addition to neuronal death. Neurite loss may result directly from a primary insult, secondary to parental neuron death, or secondary to a post-injury inflammatory response. Here, we use lipopolysaccharide and the alarmin S100β to selectively evaluate neurite loss caused by the inflammatory response. Activation of microglia and infiltrating macrophages by these stimuli causes neurite loss that far exceeds neuronal death, both in vitro and in vivo. Neurite loss is accompanied by the formation of cofilactin rods and aggregates (CARs), which are polymers of cofilin-1 and actin induced by oxidative stress and other factors. Mice deficient in either cofilin-1 or the superoxide-generating enzyme NADPH oxidase-2 show reduced CAR formation, neurite loss, and motor impairment. The findings identify a mechanism by which inflammation leads to neurite loss via CAR formation and highlight the relevance of neurite loss to functional impairment.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Published by Elsevier Inc.)
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معلومات مُعتمدة: I01 BX004884 United States BX BLRD VA; R21 AG044812 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: CP: Neuroscience; NADPH-oxidase; actin; axon; cofilin-1; dendrite; inflammation; microglia; neuron; superoxide
تواريخ الأحداث: Date Created: 20240307 Date Completed: 20240401 Latest Revision: 20240505
رمز التحديث: 20240505
مُعرف محوري في PubMed: PMC11068216
DOI: 10.1016/j.celrep.2024.113914
PMID: 38451813
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2024.113914