دورية أكاديمية
أعرض في EDS

Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin.

التفاصيل البيبلوغرافية
العنوان: Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin.
المؤلفون: Patel H; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Minkah NK; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Kumar S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Zanghi G; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Schepis A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Goswami D; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Armstrong J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Abatiyow BA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Betz W; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Reynolds L; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Camargo N; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Sheikh AA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Kappe SHI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.; Department of Pediatrics, University of Washington, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.; Department of Global Health, University of Washington, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.
المصدر: Nature communications [Nat Commun] 2024 Mar 07; Vol. 15 (1), pp. 2104. Date of Electronic Publication: 2024 Mar 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Malaria Vaccines* , Malaria*/parasitology , Plasmodium* , Liver Diseases*, Female ; Humans ; Hepcidins ; Liver
مستخلص: Malaria-causing Plasmodium parasites first replicate as liver stages (LS), which then seed symptomatic blood stage (BS) infection. Emerging evidence suggests that these stages impact each other via perturbation of host responses, and this influences the outcome of natural infection. We sought to understand whether the parasite stage interplay would affect live-attenuated whole parasite vaccination, since the efficacy of whole parasite vaccines strongly correlates with their extend of development in the liver. We thus investigated the impact of BS infection on LS development of genetically attenuated and wildtype parasites in female rodent malaria models and observed that for both, LS infection suffered severe suppression during concurrent BS infection. Strikingly and in contrast to previously published studies, we find that the BS-induced iron-regulating hormone hepcidin is not mediating suppression of LS development. Instead, we demonstrate that BS-induced host interferons are the main mediators of LS developmental suppression. The type of interferon involved depended on the BS-causing parasite species. Our study provides important mechanistic insights into the BS-mediated suppression of LS development. This has direct implications for understanding the outcomes of live-attenuated Plasmodium parasite vaccination in malaria-endemic areas and might impact the epidemiology of natural malaria infection.
(© 2024. The Author(s).)
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المشرفين على المادة: 0 (Malaria Vaccines)
0 (Hepcidins)
تواريخ الأحداث: Date Created: 20240307 Date Completed: 20240311 Latest Revision: 20240311
رمز التحديث: 20240311
مُعرف محوري في PubMed: PMC10920859
DOI: 10.1038/s41467-024-46270-3
PMID: 38453916
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-46270-3