دورية أكاديمية
أعرض في EDS

Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8-9 years in a multi-site longitudinal study.

التفاصيل البيبلوغرافية
العنوان: Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8-9 years in a multi-site longitudinal study.
المؤلفون: Sherris AR; Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US. asherris@uw.edu., Loftus CT; Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US., Szpiro AA; Department of Biostatistics, University of Washington, Seattle, WA, US., Dearborn LC; Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US., Hazlehurst MF; Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US., Carroll KN; Icahn School of Medicine at Mount Sinai, New York, NY, US., Moore PE; Vanderbilt University Medical Center, Nashville, TN, US., Adgent MA; Vanderbilt University Medical Center, Nashville, TN, US., Barrett ES; Rutgers University School of Public Health, Piscataway, NJ, US., Bush NR; University of California, San Francisco, CA, US., Day DB; Seattle Children's Research Institute, Seattle, WA, US., Kannan K; New York State Department of Health, Albany, NY, US., LeWinn KZ; University of California, San Francisco, CA, US., Nguyen RHN; University of Minnesota, Minneapolis, MN, US., Ni Y; San Diego State University, San Diego, CA, US., Riederer AM; Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US., Robinson M; New York University, New York, NY, US., Sathyanarayana S; Seattle Children's Research Institute, Seattle, WA, US., Zhao Q; University of Tennessee Health Science Center, Memphis, TN, US., Karr CJ; Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US.
المصدر: Environmental health : a global access science source [Environ Health] 2024 Mar 08; Vol. 23 (1), pp. 26. Date of Electronic Publication: 2024 Mar 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147645 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-069X (Electronic) Linking ISSN: 1476069X NLM ISO Abbreviation: Environ Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Polycyclic Aromatic Hydrocarbons*/adverse effects , Prenatal Exposure Delayed Effects*/chemically induced , Prenatal Exposure Delayed Effects*/epidemiology , Asthma*/chemically induced , Asthma*/epidemiology , Phenanthrenes*, Child ; Pregnancy ; Male ; Female ; Child, Preschool ; Humans ; Longitudinal Studies ; Respiratory Sounds
مستخلص: Background and Aim: Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhood remain unclear. We investigated these associations in socio-demographically diverse participants from the ECHO PATHWAYS multi-cohort consortium.
Methods: We included 1,081 birth parent-child dyads across five U.S. cities. Maternal urinary mono-hydroxylated PAH metabolite concentrations (OH-PAH) were measured during mid-pregnancy. Asthma at age 8-9 years and wheezing trajectory across childhood were characterized by caregiver reported asthma diagnosis and asthma/wheeze symptoms. We used logistic and multinomial regression to estimate odds ratios of asthma and childhood wheezing trajectories associated with five individual OH-PAHs, adjusting for urine specific gravity, various maternal and child characteristics, study site, prenatal and postnatal smoke exposure, and birth year and season in single metabolite and mutually adjusted models. We used multiplicative interaction terms to evaluate effect modification by child sex and explored OH-PAH mixture effects through Weighted Quantile Sum regression.
Results: The prevalence of asthma in the study population was 10%. We found limited evidence of adverse associations between pregnancy OH-PAH concentrations and asthma or wheezing trajectories. We observed adverse associations between 1/9-hydroxyphenanthrene and asthma and persistent wheeze among girls, and evidence of inverse associations with asthma for 1-hydroxynathpthalene, which was stronger among boys, though tests for effect modification by child sex were not statistically significant.
Conclusions: In a large, multi-site cohort, we did not find strong evidence of an association between prenatal exposure to PAHs and child asthma at age 8-9 years, though some adverse associations were observed among girls.
(© 2024. The Author(s).)
التعليقات: Update of: Res Sq. 2023 Jul 11;:. (PMID: 37503063)
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معلومات مُعتمدة: R01ES016863 United States NH NIH HHS; R01 ES025169 United States ES NIEHS NIH HHS; T32 ES015459 United States ES NIEHS NIH HHS; P30 ES007033 United States ES NIEHS NIH HHS; R01HL132338 United States NH NIH HHS; UG3/UH3OD023305 United States NH NIH HHS; T32ES015459 United States ES NIEHS NIH HHS; R01 HL132338 United States HL NHLBI NIH HHS; UG3/UH3OD023271 United States GF NIH HHS
فهرسة مساهمة: Keywords: Asthma; Children’s health; PAHs
المشرفين على المادة: 0 (Polycyclic Aromatic Hydrocarbons)
2433-56-9 (1-hydroxyphenanthrene)
0 (Phenanthrenes)
تواريخ الأحداث: Date Created: 20240308 Date Completed: 20240311 Latest Revision: 20240318
رمز التحديث: 20240318
مُعرف محوري في PubMed: PMC10921622
DOI: 10.1186/s12940-024-01066-2
PMID: 38454435
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-069X
DOI:10.1186/s12940-024-01066-2