دورية أكاديمية
أعرض في EDS

Detection of anti-SARS-CoV-2-Spike/RBD antibodies in vaccinated elderly from residential care facilities in Romania, April 2021.

التفاصيل البيبلوغرافية
العنوان: Detection of anti-SARS-CoV-2-Spike/RBD antibodies in vaccinated elderly from residential care facilities in Romania, April 2021.
المؤلفون: Vremera T; ECDC Fellowship Programme, EUPHEM Path, European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.; National Center for Surveillance and Control of Communicable Diseases, National Institute of Public Health, Bucharest, Romania., Furtunescu FL; National Center for Surveillance and Control of Communicable Diseases, National Institute of Public Health, Bucharest, Romania.; Department of Complementary Sciences, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania., Leustean M; Seroepidemiological Diagnostic Laboratory, Regional Centre for Public Health Bucharest, National Institute of Public Health, Bucharest, Romania., Rafila A; Department of Complementary Sciences, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania., David A; Seroepidemiological Diagnostic Laboratory, Regional Centre for Public Health Bucharest, National Institute of Public Health, Bucharest, Romania., Radu I; Seroepidemiological Diagnostic Laboratory, Regional Centre for Public Health Bucharest, National Institute of Public Health, Bucharest, Romania., Cornienco AM; Seroepidemiological Diagnostic Laboratory, Regional Centre for Public Health Bucharest, National Institute of Public Health, Bucharest, Romania., Gatea A; Seroepidemiological Diagnostic Laboratory, Regional Centre for Public Health Bucharest, National Institute of Public Health, Bucharest, Romania., Ilie C; Seroepidemiological Diagnostic Laboratory, Regional Centre for Public Health Bucharest, National Institute of Public Health, Bucharest, Romania., Iancu LS; 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.; Regional Centre for Public Health Iasi, National Institute of Public Health, Bucharest, Romania., Pistol A; National Center for Surveillance and Control of Communicable Diseases, National Institute of Public Health, Bucharest, Romania.; Department of Complementary Sciences, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.
المصدر: Frontiers in epidemiology [Front Epidemiol] 2022 Sep 20; Vol. 2, pp. 944820. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918419158106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2674-1199 (Electronic) Linking ISSN: 26741199 NLM ISO Abbreviation: Front Epidemiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2021]-
مستخلص: Introduction: SARS-CoV-2 infection rates and related mortality in elderly from residential care facilities are high. The aim of this study was to explore the immune status after COVID-19 vaccination in people 65 years and older.
Methods: The study involved volunteer participants living in residential care facilities. The level of anti-Spike/RBD antibodies was measured at 2-12 weeks after complete vaccination, using chemiluminescent microparticle immunoassay ( SARS-CoV-2 IgG II Quant Abbott) .
Results: We have analyzed 635 serum samples collected from volunteers living in 21 Residential Care Facilities. With one exception, in which the vaccination was done with the Moderna vaccine, all volunteers received the Pfizer-Comirnaty vaccine. Individuals enrolled in the study had ages between 65-110 years (median 79 years). Of the people tested, 54.8% reported at least one comorbidity and 59.2% reported having had COVID-19 before vaccination. The presence of anti-S/RBD antibodies at a protective level was detected in 98.7% of those tested ( n = 627 persons) with a wide variation of antibody levels, from 7.1 to 5,680 BAU/ml (median 1287 BAU/ml). Antibody levels appeared to be significantly correlated to previous infection ( r = 0.302, p = 0.000).
Conclusions: The study revealed the presence of anti-SARS CoV-2 antibodies in a significant percentage of those tested (98.7%). Of these, more than half had high antibody levels. Pre-vaccination COVID-19 was the only factor found to be associated with higher anti-S/RBD levels. The significant response in elderly people, even in those with comorbidities, supports the vaccination measure for this category, irrespective of associated disabilities or previous infection.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Vremera, Furtunescu, Leustean, Rafila, David, Radu, Cornienco, Gatea, Ilie, Iancu and Pistol.)
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فهرسة مساهمة: Keywords: COVID-19; SARS-CoV-2 infection; anti-Spike/RBD IgG; antibody; elderly; residential care facility
تواريخ الأحداث: Date Created: 20240308 Latest Revision: 20240309
رمز التحديث: 20240309
مُعرف محوري في PubMed: PMC10910916
DOI: 10.3389/fepid.2022.944820
PMID: 38455297
قاعدة البيانات: MEDLINE
الوصف
تدمد:2674-1199
DOI:10.3389/fepid.2022.944820