دورية أكاديمية
Aedes aegypti anti-salivary proteins IgG levels in a cohort of DENV-like symptoms subjects from a dengue-endemic region in Colombia.
| العنوان: | Aedes aegypti anti-salivary proteins IgG levels in a cohort of DENV-like symptoms subjects from a dengue-endemic region in Colombia. |
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| المؤلفون: | Olajiga OM; Department of Entomology, Kansas State University, Manhattan, KS, United States., Marin-Lopez A; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States., Cardenas JC; Laboratorio Clínico, Hospital Local Los Patios, Los Patios, Colombia., Gutierrez-Silva LY; Laboratorio Clinico, E.S.E Hospital Emiro Quintero Cañizares, Ocaña, Colombia., Gonzales-Pabon MU; Laboratorio Clínico, Hospital Erasmo Meoz de Cúcuta, Cúcuta, Colombia., Maldonado-Ruiz LP; Department of Entomology, Kansas State University, Manhattan, KS, United States., Worges M; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University of New Orleans, New Orleans, LA, United States., Fikrig E; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States., Park Y; Department of Entomology, Kansas State University, Manhattan, KS, United States., Londono-Renteria B; Department of Entomology, Kansas State University, Manhattan, KS, United States.; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University of New Orleans, New Orleans, LA, United States. |
| المصدر: | Frontiers in epidemiology [Front Epidemiol] 2022 Nov 10; Vol. 2, pp. 1002857. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918419158106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2674-1199 (Electronic) Linking ISSN: 26741199 NLM ISO Abbreviation: Front Epidemiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2021]- |
| مستخلص: | Dengue fever, caused by the dengue virus (DENV), is currently a threat to about half of the world's population. DENV is mainly transmitted to the vertebrate host through the bite of a female Aedes mosquito while taking a blood meal. During this process, salivary proteins are introduced into the host skin and blood to facilitate blood acquisition. These salivary proteins modulate both local (skin) and systemic immune responses. Several salivary proteins have been identified as immunogenic inducing the production of antibodies with some of those proteins also displaying immunomodulatory properties enhancing arboviral infections. IgG antibody responses against salivary gland extracts of a diverse number of mosquitoes, as well as antibody responses against the Ae. aegypti peptide, Nterm-34 kDa, have been suggested as biomarkers of human exposure to mosquito bites while antibodies against AgBR1 and NeSt1 proteins have been investigated for their potential protective effect against Zika virus (ZIKV) and West Nile virus infections. Thus, we were interested in evaluating whether IgG antibodies against AgBR1, NeSt1, Nterm-34 kDa peptide, and SGE were associated with DENV infections and clinical characteristics. For this, we tested samples from volunteers living in a dengue fever endemic area in Colombia in 2019 for the presence of IgG antibodies against those salivary proteins and peptides using an ELISA test. Results from this pilot study suggest an involvement of antibody responses against salivary proteins in dengue disease progression. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Olajiga, Marin-Lopez, Cardenas, Gutierrez-Silva, Gonzales-Pabon, Maldonado-Ruiz, Worges, Fikrig, Park and Londono-Renteria.) |
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| فهرسة مساهمة: | Keywords: Ae. aegypti; dengue; febrile; immunoglobulin G; pathogenesis; salivary proteins; vector borne disease |
| تواريخ الأحداث: | Date Created: 20240308 Latest Revision: 20240309 |
| رمز التحديث: | 20240309 |
| مُعرف محوري في PubMed: | PMC10910902 |
| DOI: | 10.3389/fepid.2022.1002857 |
| PMID: | 38455331 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2674-1199 |
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| DOI: | 10.3389/fepid.2022.1002857 |