دورية أكاديمية
أعرض في EDS

Myocardial tissue expression of mRNA and preoperative neutrophil-lymphocyte ratio in children undergoing congenital heart surgery.

التفاصيل البيبلوغرافية
العنوان: Myocardial tissue expression of mRNA and preoperative neutrophil-lymphocyte ratio in children undergoing congenital heart surgery.
المؤلفون: Manuel V; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.; Cardiovascular and Thoracic Service, Complexo Hospitalar de Doenças Cardio-Pumonares Cardeal Dom Alexandre do Nascimento, Luanda, Angola., Miana LA; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Fonseca-Alaniz MH; Laboratory of Genetics and Molecular Cardiology, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Hernan GC; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Tenório DF; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Bado C; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., de Carvalho MLP; Laboratory of Genetics and Molecular Cardiology, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Meirelles M; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Telles JPM; Department of Neurology, Instituto Central, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Penha JG; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Tanamati C; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Caneo LF; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Jatene FB; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil., Jatene MB; Cardiovascular Division, Instituto do Coração (Heart Institute), Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.
المصدر: Translational pediatrics [Transl Pediatr] 2024 Feb 29; Vol. 13 (2), pp. 248-259. Date of Electronic Publication: 2024 Feb 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: AME Publishing Company Country of Publication: China NLM ID: 101649179 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2224-4344 (Print) Linking ISSN: 22244336 NLM ISO Abbreviation: Transl Pediatr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Hong Kong : AME Publishing Company
مستخلص: Background: The neutrophil-lymphocyte ratio (NLR) is an easily accessible and inexpensive biomarker that has been shown to predict morbidity and mortality in congenital cardiac surgery. However, its regulatory mechanism remains unclear. This study aims to compare and correlate the tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-10 messenger RNAs (mRNAs) with the NLR in patients with tetralogy of Fallot (ToF) and ventricular septal defect (VSD).
Methods: A prospective translational study was conducted on 10 children with ToF and 10 with VSD, aged between 1 and 24 months. The NLR was calculated from the blood count taken 24 hours before surgery. The expression of these mRNAs was analyzed in the myocardial tissue of the right atrium prior to cardiopulmonary bypass.
Results: Patients with ToF exhibited a higher NLR [ToF 0.46 (interquartile range; IQR) 0.90; VSD 0.28 (IQR 0.17); P=0.02], longer mechanical ventilation time [ToF 24 h (IQR 93); VSD 5.5 h (IQR 8); P<0.001], increased use of vasoactive drugs [ToF 2 days (IQR 1.75); VSD 0 (IQR 1); P=0.01], and longer ICU [ToF 5.5 (IQR 1); VSD 2 (IQR 0.75); P=0.02] and hospital length of stays [ToF 18 days (IQR 17.5); VSD 8.5 days (IQR 2.5); P<0.001]. A negative correlation was found between NLR and oxygen saturation (SaO 2 ) (r=-0.44; P=0.002). In terms of mRNA expression, the ToF group showed a lower expression of IL-10 mRNA (P=0.03). A positive correlation was observed between IL-10-mRNA and SaO 2 (r=0.40; P=0.07), and a negative correlation with NLR (r=-0.27; P=0.14).
Conclusions: Patients with ToF demonstrated a higher preoperative NLR and lower IL-10 mRNA expression by what appears to be a pro-inflammatory phenotype of cyanotic patients.
Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-23-513/coif). The authors have no conflicts of interest to declare.
(2024 Translational Pediatrics. All rights reserved.)
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فهرسة مساهمة: Keywords: IL-10; Neutrophil-lymphocyte ratio (NLR); interleukin (IL); messenger RNA (mRNA); tetralogy of Fallot (ToF)
تواريخ الأحداث: Date Created: 20240308 Latest Revision: 20240309
رمز التحديث: 20240309
مُعرف محوري في PubMed: PMC10915444
DOI: 10.21037/tp-23-513
PMID: 38455742
قاعدة البيانات: MEDLINE
الوصف
تدمد:2224-4344
DOI:10.21037/tp-23-513