تقرير
Recurrent Serratia marcescens osteomyelitis eight years after a contaminated open fracture: a case report and review of the literature.
| العنوان: | Recurrent Serratia marcescens osteomyelitis eight years after a contaminated open fracture: a case report and review of the literature. |
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| المؤلفون: | Mayhew JA; Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University, Indianapolis, IN, USA.; Deparment of Pediatric & Adolescent Medicine, Western Michigan University Homer Stryker M. D. School of Medicine, Kalamazoo, MI, USA., Christenson JC; Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University, Indianapolis, IN, USA., Alali M; Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University, Indianapolis, IN, USA. |
| المصدر: | Translational pediatrics [Transl Pediatr] 2024 Feb 29; Vol. 13 (2), pp. 350-358. Date of Electronic Publication: 2024 Feb 23. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: AME Publishing Company Country of Publication: China NLM ID: 101649179 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2224-4344 (Print) Linking ISSN: 22244336 NLM ISO Abbreviation: Transl Pediatr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Hong Kong : AME Publishing Company |
| مستخلص: | Background: Serratia marcescens ( S. marcescens ) is an unusual cause of osteomyelitis. Infection may develop following open trauma, intravenous drug abuse, or in the presence of hardware, but osteoarticular infections outside of this context are atypical in the absence of immunodeficiency. Rarely, a chronic indolent infection may develop after open trauma with disease recurrence years after the initial injury. Case Description: We present the case of a 16-year-old male with extensive left lower extremity osteomyelitis secondary to S. marcescens eight years after an open fracture to this leg was complicated by an infection with the same organism. Suboptimal therapy of his initial infection may have contributed to persistent, latent disease before recurrence years later. Evaluation for immunodeficiency was negative and he responded well to ciprofloxacin antibiotic therapy. Conclusions: S. marcescens infection may complicate open fractures, and, if not adequately treated, a chronic, indolent infection may result, with disease recurrence years later. We stress the importance of adequate therapy for infectious complications following open fractures and discuss virulence factors of S. marcescens that may allow this organism to evade the immune system and survive subclinically within a host. The optimal therapy of S. marcescens osteomyelitis is not established and further studies are needed to best guide the therapeutic approach. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-23-492/coif). J.A.M. received funding from the Indiana University Immunology and Infectious Disease Training Program T32 (No. NIH AI060519) and the Pediatric Infectious Diseases Society Fellowship Award funded by Stanley and Susan Plotkin and Sanofi, which supported his salary during fellowship training. The other authors have no conflicts of interest to declare. (2024 Translational Pediatrics. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Serratia marcescens (S. marcescens); case report; chronic granulomatous disease; open fracture; osteomyelitis |
| تواريخ الأحداث: | Date Created: 20240308 Latest Revision: 20240309 |
| رمز التحديث: | 20240309 |
| مُعرف محوري في PubMed: | PMC10915433 |
| DOI: | 10.21037/tp-23-492 |
| PMID: | 38455744 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2224-4344 |
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| DOI: | 10.21037/tp-23-492 |